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The interplay of vaccination and vector control on small dengue networks

View Article: PubMed Central - PubMed

ABSTRACT

Dengue fever is a major public health issue affecting billions of people in over 100 countries across the globe. This challenge is growing as the invasive mosquito vectors, Aedes aegypti and Aedes albopictus, expand their distributions and increase their population sizes. Hence there is an increasing need to devise effective control methods that can contain dengue outbreaks. Here we construct an epidemiological model for virus transmission between vectors and hosts on a network of host populations distributed among city and town patches, and investigate disease control through vaccination and vector control using variants of the sterile insect technique (SIT). Analysis of the basic reproductive number and simulations indicate that host movement across this small network influences the severity of epidemics. Both vaccination and vector control strategies are investigated as methods of disease containment and our results indicate that these controls can be made more effective with mixed strategy solutions. We predict that reduced lethality through poor SIT methods or imperfectly efficacious vaccines will impact efforts to control disease spread. In particular, weakly efficacious vaccination strategies against multiple virus serotype diversity may be counter productive to disease control efforts. Even so, failings of one method may be mitigated by supplementing it with an alternative control strategy. Generally, our network approach encourages decision making to consider connected populations, to emphasise that successful control methods must effectively suppress dengue epidemics at this landscape scale.

No MeSH data available.


Related in: MedlinePlus

Compensating imperfect vector control. The results for perfectly lethal genetic control provide a baseline for comparison (dotted lines), where modified insects were released at every patch in a 2:1 ratio with the wild-type insects. Supplementing an imperfect vector control with vaccinations can offset the increase in infections that arise from reduced control lethality.
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f0025: Compensating imperfect vector control. The results for perfectly lethal genetic control provide a baseline for comparison (dotted lines), where modified insects were released at every patch in a 2:1 ratio with the wild-type insects. Supplementing an imperfect vector control with vaccinations can offset the increase in infections that arise from reduced control lethality.

Mentions: Having established how commute type, network size and control combinations interact to determine the best control methods, in this section we investigate the efficacy of these controls. So far it has been assumed that vaccines are entirely efficacious and that the introduced lethality gene is entirely stable, hence 100% lethal. Fig. 5 shows the results of relaxing the assumption of perfect control.


The interplay of vaccination and vector control on small dengue networks
Compensating imperfect vector control. The results for perfectly lethal genetic control provide a baseline for comparison (dotted lines), where modified insects were released at every patch in a 2:1 ratio with the wild-type insects. Supplementing an imperfect vector control with vaccinations can offset the increase in infections that arise from reduced control lethality.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016021&req=5

f0025: Compensating imperfect vector control. The results for perfectly lethal genetic control provide a baseline for comparison (dotted lines), where modified insects were released at every patch in a 2:1 ratio with the wild-type insects. Supplementing an imperfect vector control with vaccinations can offset the increase in infections that arise from reduced control lethality.
Mentions: Having established how commute type, network size and control combinations interact to determine the best control methods, in this section we investigate the efficacy of these controls. So far it has been assumed that vaccines are entirely efficacious and that the introduced lethality gene is entirely stable, hence 100% lethal. Fig. 5 shows the results of relaxing the assumption of perfect control.

View Article: PubMed Central - PubMed

ABSTRACT

Dengue fever is a major public health issue affecting billions of people in over 100 countries across the globe. This challenge is growing as the invasive mosquito vectors, Aedes aegypti and Aedes albopictus, expand their distributions and increase their population sizes. Hence there is an increasing need to devise effective control methods that can contain dengue outbreaks. Here we construct an epidemiological model for virus transmission between vectors and hosts on a network of host populations distributed among city and town patches, and investigate disease control through vaccination and vector control using variants of the sterile insect technique (SIT). Analysis of the basic reproductive number and simulations indicate that host movement across this small network influences the severity of epidemics. Both vaccination and vector control strategies are investigated as methods of disease containment and our results indicate that these controls can be made more effective with mixed strategy solutions. We predict that reduced lethality through poor SIT methods or imperfectly efficacious vaccines will impact efforts to control disease spread. In particular, weakly efficacious vaccination strategies against multiple virus serotype diversity may be counter productive to disease control efforts. Even so, failings of one method may be mitigated by supplementing it with an alternative control strategy. Generally, our network approach encourages decision making to consider connected populations, to emphasise that successful control methods must effectively suppress dengue epidemics at this landscape scale.

No MeSH data available.


Related in: MedlinePlus