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Detection of Occult Acute Kidney Injury in Glucose-6-Phosphate Dehydrogenase Deficiency Anemia

View Article: PubMed Central - PubMed

ABSTRACT

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia is associated with intravascular hemolysis. The freely filtered hemoglobin can damage the kidney. We aimed to assess any subclinical renal injury in G6PD children.

Methods: Sixty children were included. Thirty G6PD deficiency anemia children were enrolled during the acute hemolytic crisis and after the hemolytic episode had elapsed. Another thirty healthy children were included as controls. Serum cystatin C, creatinine levels, and urinary albumin/creatinine (A/C) ratio were measured, and the glomerular filtration rate (GFR) was calculated.

Results: Significantly higher urinary A/C ratio (p=0.001,0.002 respectively) and lower GFR (p=0.001 for both) were found during hemolysis and after the hemolytic episode compared to the controls. Also, significant higher serum cystatin C (p=0.001), creatinine (p=0.05) and A/C (p= 0.001) ratio and insignificant lower GFR (p=0.3) during acute hemolytic crisis compared to the same children after the hemolytic episode subsided.

Conclusions: G6PD deficiency anemia is associated with a variable degree of acute renal injury during acute hemolytic episodes which may persist after elapsing of the hemolytic crises.

No MeSH data available.


Comparison between studied groups regarding serum creatinine and A/C ratio.
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f3-mjhid-8-1-e2016038: Comparison between studied groups regarding serum creatinine and A/C ratio.

Mentions: During the acute hemolytic episode (group Ia), calculated GFR significantly decreased compared with normal healthy children (p=0.001) but no significant change when compared after relieving from the hemolytic episode (p=0.3) (Table 1, Figure 1). Serum cystatin C significantly decreased after the subsidence of hemolytic process (group Ib) compared with those during acute hemolysis (group Ia; p<0.001) and still elevated in those children after the subsidence of hemolysis (group Ib) compared with controls (group II; p=0.008) (Table 1, Figure 2). Urinary A/C ratio significantly increased during acute hemolysis and also after the elapse of the hemolytic process compared with the controls (p=0.001 for all) (Table 1, Figure 3).


Detection of Occult Acute Kidney Injury in Glucose-6-Phosphate Dehydrogenase Deficiency Anemia
Comparison between studied groups regarding serum creatinine and A/C ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016010&req=5

f3-mjhid-8-1-e2016038: Comparison between studied groups regarding serum creatinine and A/C ratio.
Mentions: During the acute hemolytic episode (group Ia), calculated GFR significantly decreased compared with normal healthy children (p=0.001) but no significant change when compared after relieving from the hemolytic episode (p=0.3) (Table 1, Figure 1). Serum cystatin C significantly decreased after the subsidence of hemolytic process (group Ib) compared with those during acute hemolysis (group Ia; p<0.001) and still elevated in those children after the subsidence of hemolysis (group Ib) compared with controls (group II; p=0.008) (Table 1, Figure 2). Urinary A/C ratio significantly increased during acute hemolysis and also after the elapse of the hemolytic process compared with the controls (p=0.001 for all) (Table 1, Figure 3).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia is associated with intravascular hemolysis. The freely filtered hemoglobin can damage the kidney. We aimed to assess any subclinical renal injury in G6PD children.

Methods: Sixty children were included. Thirty G6PD deficiency anemia children were enrolled during the acute hemolytic crisis and after the hemolytic episode had elapsed. Another thirty healthy children were included as controls. Serum cystatin C, creatinine levels, and urinary albumin/creatinine (A/C) ratio were measured, and the glomerular filtration rate (GFR) was calculated.

Results: Significantly higher urinary A/C ratio (p=0.001,0.002 respectively) and lower GFR (p=0.001 for both) were found during hemolysis and after the hemolytic episode compared to the controls. Also, significant higher serum cystatin C (p=0.001), creatinine (p=0.05) and A/C (p= 0.001) ratio and insignificant lower GFR (p=0.3) during acute hemolytic crisis compared to the same children after the hemolytic episode subsided.

Conclusions: G6PD deficiency anemia is associated with a variable degree of acute renal injury during acute hemolytic episodes which may persist after elapsing of the hemolytic crises.

No MeSH data available.