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Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

View Article: PubMed Central - PubMed

ABSTRACT

Background: Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.

Methods and results: This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease (CHD), and 10‐year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer‐assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease–Epidemiology Collaboration (CKD‐EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m2), those with decreased eGFR (75–89, 60–74, and <60 mL/min per 1.73 m2) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10‐year Framingham risk for CHD and 10‐year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60–89 mL/min per 1.73 m2).

Conclusions: Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10‐year Framingham risk for CHD and 10‐year ASCVD risk among Chinese adults.

No MeSH data available.


Related in: MedlinePlus

A, Distribution of estimated 10‐year Framingham risk for coronary heart disease (CHD) in the CVD and diabetes mellitus–free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and estimated glomerular filtration rate (eGFR) groups (N=181 683). (B) Distribution of estimated 10‐year risk for a first hard atherosclerotic cardiovascular diseases (ASCVD) event in the CVD‐free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and eGFR groups (N=225 005). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
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jah31646-fig-0002: A, Distribution of estimated 10‐year Framingham risk for coronary heart disease (CHD) in the CVD and diabetes mellitus–free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and estimated glomerular filtration rate (eGFR) groups (N=181 683). (B) Distribution of estimated 10‐year risk for a first hard atherosclerotic cardiovascular diseases (ASCVD) event in the CVD‐free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and eGFR groups (N=225 005). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.

Mentions: We further calculated estimated 10‐year Framingham risk for CHD in participants who were free of CVD and diabetes mellitus (n=181 683) and estimated the 10‐year risk for a first hard ASCVD event in the CVD‐free Chinese adults (n=225 005; Table 3; Figure 2). FRS and 10‐year ASCVD risk was much higher in men than in women. In this study population, the mean (±SD) FRS was 10.77% (±6.54%) in men and 2.17% (±2.72%) in women. Furthermore, 5.75% of men and 0.27% of women had 10‐year Framingham risk for CHD >20%. Mean (±SD) ASCVD risk score was 14.92% (±12.42%) in men and 5.45% (±7.57%) in women. A total of 64.7% men and 21.1% women had ASCVD risk ≥7.5% in this population.


Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study
A, Distribution of estimated 10‐year Framingham risk for coronary heart disease (CHD) in the CVD and diabetes mellitus–free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and estimated glomerular filtration rate (eGFR) groups (N=181 683). (B) Distribution of estimated 10‐year risk for a first hard atherosclerotic cardiovascular diseases (ASCVD) event in the CVD‐free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and eGFR groups (N=225 005). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
© Copyright Policy - creativeCommonsBy-nc-nd
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5015372&req=5

jah31646-fig-0002: A, Distribution of estimated 10‐year Framingham risk for coronary heart disease (CHD) in the CVD and diabetes mellitus–free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and estimated glomerular filtration rate (eGFR) groups (N=181 683). (B) Distribution of estimated 10‐year risk for a first hard atherosclerotic cardiovascular diseases (ASCVD) event in the CVD‐free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and eGFR groups (N=225 005). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
Mentions: We further calculated estimated 10‐year Framingham risk for CHD in participants who were free of CVD and diabetes mellitus (n=181 683) and estimated the 10‐year risk for a first hard ASCVD event in the CVD‐free Chinese adults (n=225 005; Table 3; Figure 2). FRS and 10‐year ASCVD risk was much higher in men than in women. In this study population, the mean (±SD) FRS was 10.77% (±6.54%) in men and 2.17% (±2.72%) in women. Furthermore, 5.75% of men and 0.27% of women had 10‐year Framingham risk for CHD >20%. Mean (±SD) ASCVD risk score was 14.92% (±12.42%) in men and 5.45% (±7.57%) in women. A total of 64.7% men and 21.1% women had ASCVD risk ≥7.5% in this population.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.

Methods and results: This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease (CHD), and 10‐year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer‐assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease–Epidemiology Collaboration (CKD‐EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m2), those with decreased eGFR (75–89, 60–74, and <60 mL/min per 1.73 m2) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10‐year Framingham risk for CHD and 10‐year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60–89 mL/min per 1.73 m2).

Conclusions: Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10‐year Framingham risk for CHD and 10‐year ASCVD risk among Chinese adults.

No MeSH data available.


Related in: MedlinePlus