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Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

View Article: PubMed Central - PubMed

ABSTRACT

Background: Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.

Methods and results: This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease (CHD), and 10‐year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer‐assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease–Epidemiology Collaboration (CKD‐EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m2), those with decreased eGFR (75–89, 60–74, and <60 mL/min per 1.73 m2) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10‐year Framingham risk for CHD and 10‐year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60–89 mL/min per 1.73 m2).

Conclusions: Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10‐year Framingham risk for CHD and 10‐year ASCVD risk among Chinese adults.

No MeSH data available.


Related in: MedlinePlus

Association between kidney function and cardiometabolic risk factors. Prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by estimated glomerular filtration rate (eGFR) status in men (A) and women (B). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
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jah31646-fig-0001: Association between kidney function and cardiometabolic risk factors. Prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by estimated glomerular filtration rate (eGFR) status in men (A) and women (B). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.

Mentions: General characteristics of the study population by eGFR categories are presented in Table 1. The mean age (years) of participants with normal eGFR (≥90 mL/min per 1.73 m2) was 56 in men and 54 in women. Compared with individuals with normal eGFR, men and women with reduced kidney function or CKD were much older, having a lower proportion of current smoker, higher levels of fasting and postprandial blood glucose, HbA1c, HOMA‐IR, BP, serum cholesterol, triglyceride, and LDL and lower HDL level, as well as a larger waist circumference. Logistic regression analysis indicated that the reduced eGFR was associated with a higher prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.05; Figure 1; Table 2).


Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study
Association between kidney function and cardiometabolic risk factors. Prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by estimated glomerular filtration rate (eGFR) status in men (A) and women (B). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
© Copyright Policy - creativeCommonsBy-nc-nd
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5015372&req=5

jah31646-fig-0001: Association between kidney function and cardiometabolic risk factors. Prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by estimated glomerular filtration rate (eGFR) status in men (A) and women (B). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
Mentions: General characteristics of the study population by eGFR categories are presented in Table 1. The mean age (years) of participants with normal eGFR (≥90 mL/min per 1.73 m2) was 56 in men and 54 in women. Compared with individuals with normal eGFR, men and women with reduced kidney function or CKD were much older, having a lower proportion of current smoker, higher levels of fasting and postprandial blood glucose, HbA1c, HOMA‐IR, BP, serum cholesterol, triglyceride, and LDL and lower HDL level, as well as a larger waist circumference. Logistic regression analysis indicated that the reduced eGFR was associated with a higher prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.05; Figure 1; Table 2).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.

Methods and results: This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10&#8208;year Framingham risk for coronary heart disease (CHD), and 10&#8208;year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239&nbsp;832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer&#8208;assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease&ndash;Epidemiology Collaboration (CKD&#8208;EPI) equation&nbsp;was used to calculate eGFR. Compared with individuals with normal eGFR (&ge;90&nbsp;mL/min per 1.73&nbsp;m2), those with decreased eGFR (75&ndash;89, 60&ndash;74, and &lt;60&nbsp;mL/min per 1.73&nbsp;m2) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all &lt;0.001). Moreover, a significantly higher 10&#8208;year Framingham risk for CHD and 10&#8208;year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60&ndash;89&nbsp;mL/min per 1.73&nbsp;m2).

Conclusions: Even mildly reduced eGFR (under 90&nbsp;mL/min per 1.73&nbsp;m2) is associated with elevated 10&#8208;year Framingham risk for CHD and 10&#8208;year ASCVD risk among Chinese adults.

No MeSH data available.


Related in: MedlinePlus