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Draft genome sequence of Enterococcus faecium strain LMG 8148

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ABSTRACT

Enterococcus faecium, traditionally considered a harmless gut commensal, is emerging as an important nosocomial pathogen showing increasing rates of multidrug resistance. We report the draft genome sequence of E. faecium strain LMG 8148, isolated in 1968 from a human in Gothenburg, Sweden. The draft genome has a total length of 2,697,490 bp, a GC-content of 38.3 %, and 2,402 predicted protein-coding sequences. The isolation of this strain predates the emergence of E. faecium as a nosocomial pathogen. Consequently, its genome can be useful in comparative genomic studies investigating the evolution of E. faecium as a pathogen.

No MeSH data available.


Phase-contrast micrograph of E. faecium LMG 8148
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Fig1: Phase-contrast micrograph of E. faecium LMG 8148

Mentions: Enterococcus is a large genus of Gram-positive, non-sporulating, facultative anaerobic, round-shaped, lactic acid-producing bacteria (Table 1) [5]. E. faecium belongs to the family Enterococcaceae, order Lactobacillales, class Bacilli, and phylum Firmicutes. Microscopically, enterococci are often observed as pairs or short chains of cells (Fig. 1) [5]. They were classified as group D streptococci until assigned a separate genus in 1984 [6]. E. faecalis and E. faecium are the two most prominent species within the genus. Enterococci can grow in a wide range of environmental conditions, including temperature (5-50 °C), pH (4.6-9.9), 40 % (w/v) bile salts, and 6.5 % NaCl [7]. To investigate evolutionary relationships with other Enterococcus species and E. faecium strains, a phylogenetic tree was constructed using 16S rDNA sequences (Fig. 2). As expected, E. faeciumLMG 8148 forms a cluster with the other E. faecium strains.Table 1


Draft genome sequence of Enterococcus faecium strain LMG 8148
Phase-contrast micrograph of E. faecium LMG 8148
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5015329&req=5

Fig1: Phase-contrast micrograph of E. faecium LMG 8148
Mentions: Enterococcus is a large genus of Gram-positive, non-sporulating, facultative anaerobic, round-shaped, lactic acid-producing bacteria (Table 1) [5]. E. faecium belongs to the family Enterococcaceae, order Lactobacillales, class Bacilli, and phylum Firmicutes. Microscopically, enterococci are often observed as pairs or short chains of cells (Fig. 1) [5]. They were classified as group D streptococci until assigned a separate genus in 1984 [6]. E. faecalis and E. faecium are the two most prominent species within the genus. Enterococci can grow in a wide range of environmental conditions, including temperature (5-50 °C), pH (4.6-9.9), 40 % (w/v) bile salts, and 6.5 % NaCl [7]. To investigate evolutionary relationships with other Enterococcus species and E. faecium strains, a phylogenetic tree was constructed using 16S rDNA sequences (Fig. 2). As expected, E. faeciumLMG 8148 forms a cluster with the other E. faecium strains.Table 1

View Article: PubMed Central - PubMed

ABSTRACT

Enterococcus faecium, traditionally considered a harmless gut commensal, is emerging as an important nosocomial pathogen showing increasing rates of multidrug resistance. We report the draft genome sequence of E. faecium strain LMG 8148, isolated in 1968 from a human in Gothenburg, Sweden. The draft genome has a total length of 2,697,490 bp, a GC-content of 38.3 %, and 2,402 predicted protein-coding sequences. The isolation of this strain predates the emergence of E. faecium as a nosocomial pathogen. Consequently, its genome can be useful in comparative genomic studies investigating the evolution of E. faecium as a pathogen.

No MeSH data available.