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Prospective assessment of the quality of life before, during and after image guided intensity modulated radiotherapy for prostate cancer

View Article: PubMed Central - PubMed

ABSTRACT

Background: Radiotherapy (RT) in combination with androgen deprivation therapy (ADT) for prostate cancer (PCa) carries a risk of gastrointestinal (GI) and genitourinary toxicity, which might affect the quality of life (QoL). The purpose of this study was to assess the QoL in patients with PCa before, during and after radiotherapy (RT) and to compare the QoL 1 year after RT to a normal population.

Methods: The QoL was evaluated prospectively by the self-administered questionnaire SF-36 in 87 patients with PCa. The SF-36 was completed before RT (baseline), at start of RT, at end of RT and 1 year after RT. A mixed model analysis was used to determine the changes in QoL at each time point compared to baseline. The patients’ QoL 1 year after RT was compared to a normal population consisting of 462 reference subjects matched on age and education.

Results: One year after RT, patients reported significantly less pain and significantly fewer limitations due to their physical health compared to baseline. Compared to the normal population, patients reported significantly less pain 1 year after RT. However, patients also reported significantly less vitality, worse mental health as well as significantly more limitations due to physical and mental health 1 year after RT compared to the normal population.

Conclusions: In this study, patients with PCa did not experience significant impairment in the QoL 1 year after RT compared to baseline. However, patients reported significantly worse mental health before, during and 1 year after RT compared to the normal population.

No MeSH data available.


The graphs show the five scales in the mental domain with mean scores and 95 % confidence intervals for patients (solid line) at baseline, at the start of RT, at the end of RT and 1 year after RT as well as the mean scores for the normal population (dashed line)
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Fig2: The graphs show the five scales in the mental domain with mean scores and 95 % confidence intervals for patients (solid line) at baseline, at the start of RT, at the end of RT and 1 year after RT as well as the mean scores for the normal population (dashed line)

Mentions: The mean SF-36 scores with 95 % confidence intervals for patients and the normal population are shown in Figs. 1 and 2. The SF-36 scores for the normal population are displayed throughout the entire study period for comparison although the values represent one measurement only corresponding to 1 year after RT.Fig. 1


Prospective assessment of the quality of life before, during and after image guided intensity modulated radiotherapy for prostate cancer
The graphs show the five scales in the mental domain with mean scores and 95 % confidence intervals for patients (solid line) at baseline, at the start of RT, at the end of RT and 1 year after RT as well as the mean scores for the normal population (dashed line)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5015215&req=5

Fig2: The graphs show the five scales in the mental domain with mean scores and 95 % confidence intervals for patients (solid line) at baseline, at the start of RT, at the end of RT and 1 year after RT as well as the mean scores for the normal population (dashed line)
Mentions: The mean SF-36 scores with 95 % confidence intervals for patients and the normal population are shown in Figs. 1 and 2. The SF-36 scores for the normal population are displayed throughout the entire study period for comparison although the values represent one measurement only corresponding to 1 year after RT.Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: Radiotherapy (RT) in combination with androgen deprivation therapy (ADT) for prostate cancer (PCa) carries a risk of gastrointestinal (GI) and genitourinary toxicity, which might affect the quality of life (QoL). The purpose of this study was to assess the QoL in patients with PCa before, during and after radiotherapy (RT) and to compare the QoL 1 year after RT to a normal population.

Methods: The QoL was evaluated prospectively by the self-administered questionnaire SF-36 in 87 patients with PCa. The SF-36 was completed before RT (baseline), at start of RT, at end of RT and 1 year after RT. A mixed model analysis was used to determine the changes in QoL at each time point compared to baseline. The patients’ QoL 1 year after RT was compared to a normal population consisting of 462 reference subjects matched on age and education.

Results: One year after RT, patients reported significantly less pain and significantly fewer limitations due to their physical health compared to baseline. Compared to the normal population, patients reported significantly less pain 1 year after RT. However, patients also reported significantly less vitality, worse mental health as well as significantly more limitations due to physical and mental health 1 year after RT compared to the normal population.

Conclusions: In this study, patients with PCa did not experience significant impairment in the QoL 1 year after RT compared to baseline. However, patients reported significantly worse mental health before, during and 1 year after RT compared to the normal population.

No MeSH data available.