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Synthesis of semicrystalline nanocapsular structures obtained by Thermally Induced Phase Separation in nanoconfinement

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ABSTRACT

Phase separation of a polymer solution exhibits a peculiar behavior when induced in a nanoconfinement. The energetic constraints introduce additional interactions between the polymer segments that reduce the number of available configurations. In our work, this effect is exploited in a one-step strategy called nanoconfined-Thermally Induced Phase Separation (nc-TIPS) to promote the crystallization of polymer chains into nanocapsular structures of controlled size and shell thickness. This is accomplished by performing a quench step of a low-concentrated PLLA-dioxane-water solution included in emulsions of mean droplet size <500 nm acting as nanodomains. The control of nanoconfinement conditions enables not only the production of nanocapsules with a minimum mean particle diameter of 70 nm but also the tunability of shell thickness and its crystallinity degree. The specific properties of the developed nanocapsular architectures have important implications on release mechanism and loading capability of hydrophilic and lipophilic payload compounds.

No MeSH data available.


Loading capability and release mechanism.(a–c) STED high-resolution images of randomly dispersed fluorescence of (a) 250 nm, (b) 115 nm and (c) 95 nm. (d) Effect of polymer structure and drug release characteristics. Dye release profile of loaded nanocapsules as a function of size and shell thickness for different % of dye loadings. The graph also confirms the release mechanism typical of micro and nanocapsules.
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f4: Loading capability and release mechanism.(a–c) STED high-resolution images of randomly dispersed fluorescence of (a) 250 nm, (b) 115 nm and (c) 95 nm. (d) Effect of polymer structure and drug release characteristics. Dye release profile of loaded nanocapsules as a function of size and shell thickness for different % of dye loadings. The graph also confirms the release mechanism typical of micro and nanocapsules.

Mentions: The loading capability and release mechanism of the produced nanocapsules are reported in Fig. 4a–c, where nanocapsules having different diameter are observed by Stimulated Emission Depletion (STED). The peculiar behavior of the release mechanism is showed in Fig. 4d. The cumulative release is conducted from nanocapsules of different size and shell thickness. In particular, the cumulative dye release from SC-NCs is displayed for nanoparticles of size ranging from 70 to 250 nm.


Synthesis of semicrystalline nanocapsular structures obtained by Thermally Induced Phase Separation in nanoconfinement
Loading capability and release mechanism.(a–c) STED high-resolution images of randomly dispersed fluorescence of (a) 250 nm, (b) 115 nm and (c) 95 nm. (d) Effect of polymer structure and drug release characteristics. Dye release profile of loaded nanocapsules as a function of size and shell thickness for different % of dye loadings. The graph also confirms the release mechanism typical of micro and nanocapsules.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5015022&req=5

f4: Loading capability and release mechanism.(a–c) STED high-resolution images of randomly dispersed fluorescence of (a) 250 nm, (b) 115 nm and (c) 95 nm. (d) Effect of polymer structure and drug release characteristics. Dye release profile of loaded nanocapsules as a function of size and shell thickness for different % of dye loadings. The graph also confirms the release mechanism typical of micro and nanocapsules.
Mentions: The loading capability and release mechanism of the produced nanocapsules are reported in Fig. 4a–c, where nanocapsules having different diameter are observed by Stimulated Emission Depletion (STED). The peculiar behavior of the release mechanism is showed in Fig. 4d. The cumulative release is conducted from nanocapsules of different size and shell thickness. In particular, the cumulative dye release from SC-NCs is displayed for nanoparticles of size ranging from 70 to 250 nm.

View Article: PubMed Central - PubMed

ABSTRACT

Phase separation of a polymer solution exhibits a peculiar behavior when induced in a nanoconfinement. The energetic constraints introduce additional interactions between the polymer segments that reduce the number of available configurations. In our work, this effect is exploited in a one-step strategy called nanoconfined-Thermally Induced Phase Separation (nc-TIPS) to promote the crystallization of polymer chains into nanocapsular structures of controlled size and shell thickness. This is accomplished by performing a quench step of a low-concentrated PLLA-dioxane-water solution included in emulsions of mean droplet size <500 nm acting as nanodomains. The control of nanoconfinement conditions enables not only the production of nanocapsules with a minimum mean particle diameter of 70 nm but also the tunability of shell thickness and its crystallinity degree. The specific properties of the developed nanocapsular architectures have important implications on release mechanism and loading capability of hydrophilic and lipophilic payload compounds.

No MeSH data available.