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Removing Noises Induced by Gamma Radiation in Cerenkov Luminescence Imaging Using a Temporal Median Filter

View Article: PubMed Central - PubMed

ABSTRACT

Cerenkov luminescence imaging (CLI) can provide information of medical radionuclides used in nuclear imaging based on Cerenkov radiation, which makes it possible for optical means to image clinical radionuclide labeled probes. However, the exceptionally weak Cerenkov luminescence (CL) from Cerenkov radiation is susceptible to lots of impulse noises introduced by high energy gamma rays generating from the decays of radionuclides. In this work, a temporal median filter is proposed to remove this kind of impulse noises. Unlike traditional CLI collecting a single CL image with long exposure time and smoothing it using median filter, the proposed method captures a temporal sequence of CL images with shorter exposure time and employs a temporal median filter to smooth a temporal sequence of pixels. Results of in vivo experiments demonstrated that the proposed temporal median method can effectively remove random pulse noises induced by gamma radiation and achieve a robust CLI image.

No MeSH data available.


Numerical simulation of CL image. (a) The digital mouse and CL source location. (b) The simulated CLI image. (c) The fusion image of simulated CL and CT data. (d) The fusion image of simulated CL with impulse noises and CT data.
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fig2: Numerical simulation of CL image. (a) The digital mouse and CL source location. (b) The simulated CLI image. (c) The fusion image of simulated CL and CT data. (d) The fusion image of simulated CL with impulse noises and CT data.

Mentions: A Monte Carlo simulation using MOSE software based on digital mouse atlas is conducted to get the CL image. A point light source mimicking CL source generated from medical isotopes is subcutaneously embedded on back of the digital mouse with the depth about 5 mm as shown in Figure 2(a). The optical parameters μa and μs of each organ under the wavelength of 620 nm are adopted from [22]. Figure 2(b) is the simulated CL image, and Figure 2(c) is the fused image with mouse atlas. Two levels of random noises were added into the CL image to simulate dark noises of CCD with low values and impulse noises induced by gamma radiation with high values (Figure 2(d)).


Removing Noises Induced by Gamma Radiation in Cerenkov Luminescence Imaging Using a Temporal Median Filter
Numerical simulation of CL image. (a) The digital mouse and CL source location. (b) The simulated CLI image. (c) The fusion image of simulated CL and CT data. (d) The fusion image of simulated CL with impulse noises and CT data.
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Related In: Results  -  Collection

License
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fig2: Numerical simulation of CL image. (a) The digital mouse and CL source location. (b) The simulated CLI image. (c) The fusion image of simulated CL and CT data. (d) The fusion image of simulated CL with impulse noises and CT data.
Mentions: A Monte Carlo simulation using MOSE software based on digital mouse atlas is conducted to get the CL image. A point light source mimicking CL source generated from medical isotopes is subcutaneously embedded on back of the digital mouse with the depth about 5 mm as shown in Figure 2(a). The optical parameters μa and μs of each organ under the wavelength of 620 nm are adopted from [22]. Figure 2(b) is the simulated CL image, and Figure 2(c) is the fused image with mouse atlas. Two levels of random noises were added into the CL image to simulate dark noises of CCD with low values and impulse noises induced by gamma radiation with high values (Figure 2(d)).

View Article: PubMed Central - PubMed

ABSTRACT

Cerenkov luminescence imaging (CLI) can provide information of medical radionuclides used in nuclear imaging based on Cerenkov radiation, which makes it possible for optical means to image clinical radionuclide labeled probes. However, the exceptionally weak Cerenkov luminescence (CL) from Cerenkov radiation is susceptible to lots of impulse noises introduced by high energy gamma rays generating from the decays of radionuclides. In this work, a temporal median filter is proposed to remove this kind of impulse noises. Unlike traditional CLI collecting a single CL image with long exposure time and smoothing it using median filter, the proposed method captures a temporal sequence of CL images with shorter exposure time and employs a temporal median filter to smooth a temporal sequence of pixels. Results of in vivo experiments demonstrated that the proposed temporal median method can effectively remove random pulse noises induced by gamma radiation and achieve a robust CLI image.

No MeSH data available.