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Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes

View Article: PubMed Central - PubMed

ABSTRACT

There are 2 intrinsic networks in the human brain: the task positive network (TPN) and task negative network (alternately termed the default mode network, DMN) in which inverse correlations have been observed during resting state and event-related functional magnetic resonance imaging (fMRI). The antagonism between the 2 networks might indicate a dynamic interaction in the brain that is associated with development.

To evaluate the alterations in the relations of the 2 networks in children with benign childhood epilepsy with centrotemporal spikes (BECTS), resting state fMRI was performed in 17 patients with BECTS and 17 healthy controls. The functional and effective connectivities of 29 nodes in the TPN and DMN were analyzed. Positive functional connectivity (FC) within the networks and negative FC between the 2 networks were observed in both groups.

The patients exhibited increased FC within both networks, particularly in the frontoparietal nodes such as the left superior frontal cortex, and enhanced antagonism between the 2 networks, suggesting abnormal functional integration of the nodes of the 2 networks in the patients. Granger causality analysis revealed a significant difference in the degree of outflow to inflow in the left superior frontal cortex and the left ventral occipital lobe.

The alterations observed in the combined functional and effective connectivity analyses might indicate an association of an abnormal ability to integrate information between the DMN and TPN and the epileptic neuropathology of BECTS and provide preliminary evidence supporting the occurrence of abnormal development in children with BECTS.

No MeSH data available.


Related in: MedlinePlus

The average Granger causality in patients with BECTS (right) and healthy controls (left). The arrows represent the direction of the effective connections. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The arrowed line represents the direction of Granger causal connection between 2 nodes.
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Figure 3: The average Granger causality in patients with BECTS (right) and healthy controls (left). The arrows represent the direction of the effective connections. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The arrowed line represents the direction of Granger causal connection between 2 nodes.

Mentions: The average values of the Granger causal flows in the patients and healthy controls are shown in the Supplementary Material (S_Table 1 for the patients and S_Table 2 for the healthy controls). The significant Granger causal flows were delineated with arrowed line in Fig. 3. The within-group level out–in degree is illustrated in Fig. 4. The pattern in the healthy controls was clearly distinct from that in the patients. Compared with the healthy controls, the patients exhibited decreased out–in degrees in the left ventral occipital lobe and the left superior frontal cortex. The main inflow and outflow connections of 2 nodes were showed in the Supplementary Material (S_Figure 1,).


Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes
The average Granger causality in patients with BECTS (right) and healthy controls (left). The arrows represent the direction of the effective connections. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The arrowed line represents the direction of Granger causal connection between 2 nodes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998445&req=5

Figure 3: The average Granger causality in patients with BECTS (right) and healthy controls (left). The arrows represent the direction of the effective connections. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The arrowed line represents the direction of Granger causal connection between 2 nodes.
Mentions: The average values of the Granger causal flows in the patients and healthy controls are shown in the Supplementary Material (S_Table 1 for the patients and S_Table 2 for the healthy controls). The significant Granger causal flows were delineated with arrowed line in Fig. 3. The within-group level out–in degree is illustrated in Fig. 4. The pattern in the healthy controls was clearly distinct from that in the patients. Compared with the healthy controls, the patients exhibited decreased out–in degrees in the left ventral occipital lobe and the left superior frontal cortex. The main inflow and outflow connections of 2 nodes were showed in the Supplementary Material (S_Figure 1,).

View Article: PubMed Central - PubMed

ABSTRACT

There are 2 intrinsic networks in the human brain: the task positive network (TPN) and task negative network (alternately termed the default mode network, DMN) in which inverse correlations have been observed during resting state and event-related functional magnetic resonance imaging (fMRI). The antagonism between the 2 networks might indicate a dynamic interaction in the brain that is associated with development.

To evaluate the alterations in the relations of the 2 networks in children with benign childhood epilepsy with centrotemporal spikes (BECTS), resting state fMRI was performed in 17 patients with BECTS and 17 healthy controls. The functional and effective connectivities of 29 nodes in the TPN and DMN were analyzed. Positive functional connectivity (FC) within the networks and negative FC between the 2 networks were observed in both groups.

The patients exhibited increased FC within both networks, particularly in the frontoparietal nodes such as the left superior frontal cortex, and enhanced antagonism between the 2 networks, suggesting abnormal functional integration of the nodes of the 2 networks in the patients. Granger causality analysis revealed a significant difference in the degree of outflow to inflow in the left superior frontal cortex and the left ventral occipital lobe.

The alterations observed in the combined functional and effective connectivity analyses might indicate an association of an abnormal ability to integrate information between the DMN and TPN and the epileptic neuropathology of BECTS and provide preliminary evidence supporting the occurrence of abnormal development in children with BECTS.

No MeSH data available.


Related in: MedlinePlus