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Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes

View Article: PubMed Central - PubMed

ABSTRACT

There are 2 intrinsic networks in the human brain: the task positive network (TPN) and task negative network (alternately termed the default mode network, DMN) in which inverse correlations have been observed during resting state and event-related functional magnetic resonance imaging (fMRI). The antagonism between the 2 networks might indicate a dynamic interaction in the brain that is associated with development.

To evaluate the alterations in the relations of the 2 networks in children with benign childhood epilepsy with centrotemporal spikes (BECTS), resting state fMRI was performed in 17 patients with BECTS and 17 healthy controls. The functional and effective connectivities of 29 nodes in the TPN and DMN were analyzed. Positive functional connectivity (FC) within the networks and negative FC between the 2 networks were observed in both groups.

The patients exhibited increased FC within both networks, particularly in the frontoparietal nodes such as the left superior frontal cortex, and enhanced antagonism between the 2 networks, suggesting abnormal functional integration of the nodes of the 2 networks in the patients. Granger causality analysis revealed a significant difference in the degree of outflow to inflow in the left superior frontal cortex and the left ventral occipital lobe.

The alterations observed in the combined functional and effective connectivity analyses might indicate an association of an abnormal ability to integrate information between the DMN and TPN and the epileptic neuropathology of BECTS and provide preliminary evidence supporting the occurrence of abnormal development in children with BECTS.

No MeSH data available.


Related in: MedlinePlus

The functional connectivity in patients BECTS (right) and healthy controls (left). The significant connections with P < 0.001 (FDR corrected for the multiple comparisons) are illustrated. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The red lines delineate the positive functional connections (within network), and the blue lines represent the negative functional connections (between 2 networks). BECT = benign childhood epilepsy with centro-temporal spikes, FDR = False Discover Rate, DMN = Default Mode Network, TPN = Task Positive Network.
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Figure 1: The functional connectivity in patients BECTS (right) and healthy controls (left). The significant connections with P < 0.001 (FDR corrected for the multiple comparisons) are illustrated. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The red lines delineate the positive functional connections (within network), and the blue lines represent the negative functional connections (between 2 networks). BECT = benign childhood epilepsy with centro-temporal spikes, FDR = False Discover Rate, DMN = Default Mode Network, TPN = Task Positive Network.

Mentions: There were 406   pairs of potential functional connections between the 29 nodes. The average functional correlation coefficients are illustrated in Fig. 1. Consistent with previous studies, both groups of subjects exhibited positive relationships within the TPN and DMN and negative relationships between the 2 networks. However, more obvious functional connections within and between networks were observed in the patients than in the healthy controls: the control group revealed 33 significantly positive functional connections and 35 marked negative functional connections; the patients with BECTS exhibited 53 positive functional connections and 61 negative functional connections. The significance level was set at P < 0.001 in 1 sample t test for each group (FDR corrected for the multiple comparisons).


Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes
The functional connectivity in patients BECTS (right) and healthy controls (left). The significant connections with P < 0.001 (FDR corrected for the multiple comparisons) are illustrated. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The red lines delineate the positive functional connections (within network), and the blue lines represent the negative functional connections (between 2 networks). BECT = benign childhood epilepsy with centro-temporal spikes, FDR = False Discover Rate, DMN = Default Mode Network, TPN = Task Positive Network.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998445&req=5

Figure 1: The functional connectivity in patients BECTS (right) and healthy controls (left). The significant connections with P < 0.001 (FDR corrected for the multiple comparisons) are illustrated. The nodes in TPN are colored in red, and the nodes in DMN are colored in blue. The red lines delineate the positive functional connections (within network), and the blue lines represent the negative functional connections (between 2 networks). BECT = benign childhood epilepsy with centro-temporal spikes, FDR = False Discover Rate, DMN = Default Mode Network, TPN = Task Positive Network.
Mentions: There were 406   pairs of potential functional connections between the 29 nodes. The average functional correlation coefficients are illustrated in Fig. 1. Consistent with previous studies, both groups of subjects exhibited positive relationships within the TPN and DMN and negative relationships between the 2 networks. However, more obvious functional connections within and between networks were observed in the patients than in the healthy controls: the control group revealed 33 significantly positive functional connections and 35 marked negative functional connections; the patients with BECTS exhibited 53 positive functional connections and 61 negative functional connections. The significance level was set at P < 0.001 in 1 sample t test for each group (FDR corrected for the multiple comparisons).

View Article: PubMed Central - PubMed

ABSTRACT

There are 2 intrinsic networks in the human brain: the task positive network (TPN) and task negative network (alternately termed the default mode network, DMN) in which inverse correlations have been observed during resting state and event-related functional magnetic resonance imaging (fMRI). The antagonism between the 2 networks might indicate a dynamic interaction in the brain that is associated with development.

To evaluate the alterations in the relations of the 2 networks in children with benign childhood epilepsy with centrotemporal spikes (BECTS), resting state fMRI was performed in 17 patients with BECTS and 17 healthy controls. The functional and effective connectivities of 29 nodes in the TPN and DMN were analyzed. Positive functional connectivity (FC) within the networks and negative FC between the 2 networks were observed in both groups.

The patients exhibited increased FC within both networks, particularly in the frontoparietal nodes such as the left superior frontal cortex, and enhanced antagonism between the 2 networks, suggesting abnormal functional integration of the nodes of the 2 networks in the patients. Granger causality analysis revealed a significant difference in the degree of outflow to inflow in the left superior frontal cortex and the left ventral occipital lobe.

The alterations observed in the combined functional and effective connectivity analyses might indicate an association of an abnormal ability to integrate information between the DMN and TPN and the epileptic neuropathology of BECTS and provide preliminary evidence supporting the occurrence of abnormal development in children with BECTS.

No MeSH data available.


Related in: MedlinePlus