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Prevalence and incidence of toxoplasmosis: a retrospective analysis of mother-child examinations, Styria, Austria, 1995 to 2012

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ABSTRACT

In Austria, mandatory screening for the prevention of congenital toxoplasmosis stipulates a serological test for antibodies against Toxoplasma gondii as early as possible in pregnancy. In the case of a seronegative result, subsequent tests at intervals of 8 weeks are requested. We analysed serological data from Styria, an Austrian federal state, to determine the seroprevalence and incidence of Toxoplasma infections. The study included 353,599 tests from 103,316 women during 158,571 pregnancies from 1995 to 2012. The age-adjusted seroprevalence decreased from 43.3% in 1995 to 31.5% in 2012, with a yearly decline of 0.84% (95% confidence interval (CI): 0. 79 -0.88). The intergravid incidence showed an annual decrease of 4.2%. The average yearly incidence of intragravid and intergravid seroconversions was 0.52% (95% CI 0.45–0.61) and 0.72% (95% CI 0.67–0.77), respectively. If the difference between these rates (p < 0.001) can be explained by the effect of primary prevention such as avoiding raw meat and taking hygiene precautions when encountering cats or preparing vegetables, only ca two of seven (28%) infections were avoided by hygiene measures taken by pregnant women. Primary prevention may therefore have its limits.

No MeSH data available.


Toxoplasma gondii infections:incidence of intra- and intergravid seroconversions in women aged 15–44 years at three-year intervals, Styria, Austria, 1995–2012
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f4: Toxoplasma gondii infections:incidence of intra- and intergravid seroconversions in women aged 15–44 years at three-year intervals, Styria, Austria, 1995–2012

Mentions: From 1995 to 2012, 167 intragravid seroconversions were registered. There was complete agreement between the cases extracted from the database and the MCB service’s internal documentation. The observation period was 31,940 person-years, for an average yearly incidence of 0.52% (95% CI 0.45–0.61) for seronegative women, see Table 1 and Figure 4.


Prevalence and incidence of toxoplasmosis: a retrospective analysis of mother-child examinations, Styria, Austria, 1995 to 2012
Toxoplasma gondii infections:incidence of intra- and intergravid seroconversions in women aged 15–44 years at three-year intervals, Styria, Austria, 1995–2012
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998422&req=5

f4: Toxoplasma gondii infections:incidence of intra- and intergravid seroconversions in women aged 15–44 years at three-year intervals, Styria, Austria, 1995–2012
Mentions: From 1995 to 2012, 167 intragravid seroconversions were registered. There was complete agreement between the cases extracted from the database and the MCB service’s internal documentation. The observation period was 31,940 person-years, for an average yearly incidence of 0.52% (95% CI 0.45–0.61) for seronegative women, see Table 1 and Figure 4.

View Article: PubMed Central - PubMed

ABSTRACT

In Austria, mandatory screening for the prevention of congenital toxoplasmosis stipulates a serological test for antibodies against Toxoplasma gondii as early as possible in pregnancy. In the case of a seronegative result, subsequent tests at intervals of 8 weeks are requested. We analysed serological data from Styria, an Austrian federal state, to determine the seroprevalence and incidence of Toxoplasma infections. The study included 353,599 tests from 103,316 women during 158,571 pregnancies from 1995 to 2012. The age-adjusted seroprevalence decreased from 43.3% in 1995 to 31.5% in 2012, with a yearly decline of 0.84% (95% confidence interval (CI): 0. 79 -0.88). The intergravid incidence showed an annual decrease of 4.2%. The average yearly incidence of intragravid and intergravid seroconversions was 0.52% (95% CI 0.45–0.61) and 0.72% (95% CI 0.67–0.77), respectively. If the difference between these rates (p < 0.001) can be explained by the effect of primary prevention such as avoiding raw meat and taking hygiene precautions when encountering cats or preparing vegetables, only ca two of seven (28%) infections were avoided by hygiene measures taken by pregnant women. Primary prevention may therefore have its limits.

No MeSH data available.