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Comparison of real-time contrast-enhanced ultrasonography and standard ultrasonography in liver cancer microwave ablation

View Article: PubMed Central - PubMed

ABSTRACT

Primary liver cancer has a high incidence and high mortality rates, and currently the only viable option is surgery, although there are a number of difficulties related to this method. The aim of the present study was to investigate the potential advantages of the real-time contrast-enhanced ultrasonography (CEUS) for microwave ablation of primary liver cancer. One hundred patients with primary liver cancer were included in the study. The patients were divided into the ordinary ultrasonography and the CEUS groups. For the ordinary ultrasonography group, the ordinary ultrasonography-guided microwave ablation method was used, while microwave ablation under the guidance of CEUS was conducted for the CEUS group. The size of lesions and clearness of the tumor boundary prior to surgery in the two groups were compared. Additionally, postoperative complications and the survival rate were monitored. Lesion boundary areas measured by CEUS were significantly larger than those measured with ordinary ultrasonography. The incidence rate of postoperative pain, fever, intra-abdominal hemorrhage and infection and other complications in the ordinary ultrasonography group were significantly higher than that in the CEUS group. The tumor recurrence rate in the CEUS group was significantly lower than that in the ordinary ultrasonography group. Seventy-two percent of patients in the CEUS group showed no progress, compared to 48% of in the ordinary ultrasonography group. The progress-free survival rate in the CEUS group after 6 months was significantly higher than that in the ordinary ultrasonography group. Disease-free survival time in the CEUS group was considerably longer than the control group. In conclusion, the guidance of real-time CEUS on the primary liver cancer microwave ablation treatment can achieve good intra-operative results. It offers a real-time guidance effect, improves survival time and reduces the incidence of complications.

No MeSH data available.


Comparison of long-term progress-free survival rate after microwave ablation between the two groups. CEUS, contrast-enhanced ultrasonography.
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f2-etm-0-0-3448: Comparison of long-term progress-free survival rate after microwave ablation between the two groups. CEUS, contrast-enhanced ultrasonography.

Mentions: We had 72 and 48% of progress-free patients in the CEUS and ordinary ultrasonography groups, respectively. The progress-free survival rate in the CEUS group after 6 months was 70%, which was higher than that of the ordinary ultrasonography group (44%). The median survival time in the ordinary ultrasonography group was 11.7 months, while the CEUS group did not reach the median survival time. Disease progress-free survival time in the CEUS group was longer than that of the ordinary ultrasonography group (P<0.05) (Fig. 2).


Comparison of real-time contrast-enhanced ultrasonography and standard ultrasonography in liver cancer microwave ablation
Comparison of long-term progress-free survival rate after microwave ablation between the two groups. CEUS, contrast-enhanced ultrasonography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998355&req=5

f2-etm-0-0-3448: Comparison of long-term progress-free survival rate after microwave ablation between the two groups. CEUS, contrast-enhanced ultrasonography.
Mentions: We had 72 and 48% of progress-free patients in the CEUS and ordinary ultrasonography groups, respectively. The progress-free survival rate in the CEUS group after 6 months was 70%, which was higher than that of the ordinary ultrasonography group (44%). The median survival time in the ordinary ultrasonography group was 11.7 months, while the CEUS group did not reach the median survival time. Disease progress-free survival time in the CEUS group was longer than that of the ordinary ultrasonography group (P<0.05) (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

Primary liver cancer has a high incidence and high mortality rates, and currently the only viable option is surgery, although there are a number of difficulties related to this method. The aim of the present study was to investigate the potential advantages of the real-time contrast-enhanced ultrasonography (CEUS) for microwave ablation of primary liver cancer. One hundred patients with primary liver cancer were included in the study. The patients were divided into the ordinary ultrasonography and the CEUS groups. For the ordinary ultrasonography group, the ordinary ultrasonography-guided microwave ablation method was used, while microwave ablation under the guidance of CEUS was conducted for the CEUS group. The size of lesions and clearness of the tumor boundary prior to surgery in the two groups were compared. Additionally, postoperative complications and the survival rate were monitored. Lesion boundary areas measured by CEUS were significantly larger than those measured with ordinary ultrasonography. The incidence rate of postoperative pain, fever, intra-abdominal hemorrhage and infection and other complications in the ordinary ultrasonography group were significantly higher than that in the CEUS group. The tumor recurrence rate in the CEUS group was significantly lower than that in the ordinary ultrasonography group. Seventy-two percent of patients in the CEUS group showed no progress, compared to 48% of in the ordinary ultrasonography group. The progress-free survival rate in the CEUS group after 6 months was significantly higher than that in the ordinary ultrasonography group. Disease-free survival time in the CEUS group was considerably longer than the control group. In conclusion, the guidance of real-time CEUS on the primary liver cancer microwave ablation treatment can achieve good intra-operative results. It offers a real-time guidance effect, improves survival time and reduces the incidence of complications.

No MeSH data available.