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Comparison of real-time contrast-enhanced ultrasonography and standard ultrasonography in liver cancer microwave ablation

View Article: PubMed Central - PubMed

ABSTRACT

Primary liver cancer has a high incidence and high mortality rates, and currently the only viable option is surgery, although there are a number of difficulties related to this method. The aim of the present study was to investigate the potential advantages of the real-time contrast-enhanced ultrasonography (CEUS) for microwave ablation of primary liver cancer. One hundred patients with primary liver cancer were included in the study. The patients were divided into the ordinary ultrasonography and the CEUS groups. For the ordinary ultrasonography group, the ordinary ultrasonography-guided microwave ablation method was used, while microwave ablation under the guidance of CEUS was conducted for the CEUS group. The size of lesions and clearness of the tumor boundary prior to surgery in the two groups were compared. Additionally, postoperative complications and the survival rate were monitored. Lesion boundary areas measured by CEUS were significantly larger than those measured with ordinary ultrasonography. The incidence rate of postoperative pain, fever, intra-abdominal hemorrhage and infection and other complications in the ordinary ultrasonography group were significantly higher than that in the CEUS group. The tumor recurrence rate in the CEUS group was significantly lower than that in the ordinary ultrasonography group. Seventy-two percent of patients in the CEUS group showed no progress, compared to 48% of in the ordinary ultrasonography group. The progress-free survival rate in the CEUS group after 6 months was significantly higher than that in the ordinary ultrasonography group. Disease-free survival time in the CEUS group was considerably longer than the control group. In conclusion, the guidance of real-time CEUS on the primary liver cancer microwave ablation treatment can achieve good intra-operative results. It offers a real-time guidance effect, improves survival time and reduces the incidence of complications.

No MeSH data available.


Related in: MedlinePlus

There was no echo nodule near the diaphragm at the right posterior lobe of the liver after the microwave ablation of primary liver cancer (right). The CEUS group during the arterial phase showed rapid overall enhancement (left). CEUS, contrast-enhanced ultrasonography.
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f1-etm-0-0-3448: There was no echo nodule near the diaphragm at the right posterior lobe of the liver after the microwave ablation of primary liver cancer (right). The CEUS group during the arterial phase showed rapid overall enhancement (left). CEUS, contrast-enhanced ultrasonography.

Mentions: During the follow-ups, in the CEUS group, we observed a tumor recurrence rate equal to 16%, which was significantly lower than the 48% found in the ordinary ultrasonography group. The difference was statistically significant (P<0.05) (Table III). The recurrent cases in the CEUS group showed abnormal enhancement inside the ablated lesions during the arterial phase or peripheral abnormal enhancement (Fig. 1).


Comparison of real-time contrast-enhanced ultrasonography and standard ultrasonography in liver cancer microwave ablation
There was no echo nodule near the diaphragm at the right posterior lobe of the liver after the microwave ablation of primary liver cancer (right). The CEUS group during the arterial phase showed rapid overall enhancement (left). CEUS, contrast-enhanced ultrasonography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998355&req=5

f1-etm-0-0-3448: There was no echo nodule near the diaphragm at the right posterior lobe of the liver after the microwave ablation of primary liver cancer (right). The CEUS group during the arterial phase showed rapid overall enhancement (left). CEUS, contrast-enhanced ultrasonography.
Mentions: During the follow-ups, in the CEUS group, we observed a tumor recurrence rate equal to 16%, which was significantly lower than the 48% found in the ordinary ultrasonography group. The difference was statistically significant (P<0.05) (Table III). The recurrent cases in the CEUS group showed abnormal enhancement inside the ablated lesions during the arterial phase or peripheral abnormal enhancement (Fig. 1).

View Article: PubMed Central - PubMed

ABSTRACT

Primary liver cancer has a high incidence and high mortality rates, and currently the only viable option is surgery, although there are a number of difficulties related to this method. The aim of the present study was to investigate the potential advantages of the real-time contrast-enhanced ultrasonography (CEUS) for microwave ablation of primary liver cancer. One hundred patients with primary liver cancer were included in the study. The patients were divided into the ordinary ultrasonography and the CEUS groups. For the ordinary ultrasonography group, the ordinary ultrasonography-guided microwave ablation method was used, while microwave ablation under the guidance of CEUS was conducted for the CEUS group. The size of lesions and clearness of the tumor boundary prior to surgery in the two groups were compared. Additionally, postoperative complications and the survival rate were monitored. Lesion boundary areas measured by CEUS were significantly larger than those measured with ordinary ultrasonography. The incidence rate of postoperative pain, fever, intra-abdominal hemorrhage and infection and other complications in the ordinary ultrasonography group were significantly higher than that in the CEUS group. The tumor recurrence rate in the CEUS group was significantly lower than that in the ordinary ultrasonography group. Seventy-two percent of patients in the CEUS group showed no progress, compared to 48% of in the ordinary ultrasonography group. The progress-free survival rate in the CEUS group after 6 months was significantly higher than that in the ordinary ultrasonography group. Disease-free survival time in the CEUS group was considerably longer than the control group. In conclusion, the guidance of real-time CEUS on the primary liver cancer microwave ablation treatment can achieve good intra-operative results. It offers a real-time guidance effect, improves survival time and reduces the incidence of complications.

No MeSH data available.


Related in: MedlinePlus