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In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

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Related in: MedlinePlus

Results of scanning electron microscope (SEM) observation. (A and B) SEM showed calcium deposits on the surface of the materials. (C and D) The bonding condition on the interface of bone and implant were presented; gaps remained between them by two weeks. (E and F) A close bonding could be seen, with tissue ingrowth of the pores at the time point of four weeks. (G and H) While it showed calcium deposits on the surface of the specimens and more inside the pores by eight weeks, the interface between had no obvious boundaries. (I and J) The sectional SEM showed osseointegration between bone and implant; bone ingrowth could be seen deep inside the pores.
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f6-etm-0-0-3472: Results of scanning electron microscope (SEM) observation. (A and B) SEM showed calcium deposits on the surface of the materials. (C and D) The bonding condition on the interface of bone and implant were presented; gaps remained between them by two weeks. (E and F) A close bonding could be seen, with tissue ingrowth of the pores at the time point of four weeks. (G and H) While it showed calcium deposits on the surface of the specimens and more inside the pores by eight weeks, the interface between had no obvious boundaries. (I and J) The sectional SEM showed osseointegration between bone and implant; bone ingrowth could be seen deep inside the pores.

Mentions: SEM showed Ca deposits on the surface of the materials (Fig. 6A and B). With regard to the bonding condition on the interface of bone and implant, gaps remained between them by two weeks (Fig. 6C and D). A close bonding was observed, with tissue ingrowth of the pores at the time point of four weeks (Fig. 6E and F). While it showed Ca deposits on the surface of the specimens, and more inside the pores by eight weeks, the interface between had no obvious boundaries (Fig. 6G and H). The sectional SEM showed osseointegration between bone and implant; bone ingrowth could be seen deeply inside the pores (Fig. 6I and J).


In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model
Results of scanning electron microscope (SEM) observation. (A and B) SEM showed calcium deposits on the surface of the materials. (C and D) The bonding condition on the interface of bone and implant were presented; gaps remained between them by two weeks. (E and F) A close bonding could be seen, with tissue ingrowth of the pores at the time point of four weeks. (G and H) While it showed calcium deposits on the surface of the specimens and more inside the pores by eight weeks, the interface between had no obvious boundaries. (I and J) The sectional SEM showed osseointegration between bone and implant; bone ingrowth could be seen deep inside the pores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998353&req=5

f6-etm-0-0-3472: Results of scanning electron microscope (SEM) observation. (A and B) SEM showed calcium deposits on the surface of the materials. (C and D) The bonding condition on the interface of bone and implant were presented; gaps remained between them by two weeks. (E and F) A close bonding could be seen, with tissue ingrowth of the pores at the time point of four weeks. (G and H) While it showed calcium deposits on the surface of the specimens and more inside the pores by eight weeks, the interface between had no obvious boundaries. (I and J) The sectional SEM showed osseointegration between bone and implant; bone ingrowth could be seen deep inside the pores.
Mentions: SEM showed Ca deposits on the surface of the materials (Fig. 6A and B). With regard to the bonding condition on the interface of bone and implant, gaps remained between them by two weeks (Fig. 6C and D). A close bonding was observed, with tissue ingrowth of the pores at the time point of four weeks (Fig. 6E and F). While it showed Ca deposits on the surface of the specimens, and more inside the pores by eight weeks, the interface between had no obvious boundaries (Fig. 6G and H). The sectional SEM showed osseointegration between bone and implant; bone ingrowth could be seen deeply inside the pores (Fig. 6I and J).

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


Related in: MedlinePlus