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In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


X-ray examination images from two, four and eight weeks postoperatively. (A) Dense prosthesis, (B) prosthesis with 40% porosity and (C) prosthesis with 70% porosity had been implanted for two weeks. (D) Dense prosthesis, (E) prosthesis with 40% porosity and (F) prosthesis with 70% porosity had been implanted for four weeks. (G) Dense prosthesis, (H) prosthesis with 40% porosity and prosthesis with (I) 70% porosity had been implanted for eight weeks. (J-L) Magnified X-ray images showed more cancellous bone around the implants by eight weeks (magnification, ×10).
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f5-etm-0-0-3472: X-ray examination images from two, four and eight weeks postoperatively. (A) Dense prosthesis, (B) prosthesis with 40% porosity and (C) prosthesis with 70% porosity had been implanted for two weeks. (D) Dense prosthesis, (E) prosthesis with 40% porosity and (F) prosthesis with 70% porosity had been implanted for four weeks. (G) Dense prosthesis, (H) prosthesis with 40% porosity and prosthesis with (I) 70% porosity had been implanted for eight weeks. (J-L) Magnified X-ray images showed more cancellous bone around the implants by eight weeks (magnification, ×10).

Mentions: All specimens in each group showed a close connection with bone tissues. No low-density shadow of bone absorption was observed in bone tissues (Fig. 5A-K). By eight weeks, more cancellous bone was observed around the implants.


In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model
X-ray examination images from two, four and eight weeks postoperatively. (A) Dense prosthesis, (B) prosthesis with 40% porosity and (C) prosthesis with 70% porosity had been implanted for two weeks. (D) Dense prosthesis, (E) prosthesis with 40% porosity and (F) prosthesis with 70% porosity had been implanted for four weeks. (G) Dense prosthesis, (H) prosthesis with 40% porosity and prosthesis with (I) 70% porosity had been implanted for eight weeks. (J-L) Magnified X-ray images showed more cancellous bone around the implants by eight weeks (magnification, ×10).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998353&req=5

f5-etm-0-0-3472: X-ray examination images from two, four and eight weeks postoperatively. (A) Dense prosthesis, (B) prosthesis with 40% porosity and (C) prosthesis with 70% porosity had been implanted for two weeks. (D) Dense prosthesis, (E) prosthesis with 40% porosity and (F) prosthesis with 70% porosity had been implanted for four weeks. (G) Dense prosthesis, (H) prosthesis with 40% porosity and prosthesis with (I) 70% porosity had been implanted for eight weeks. (J-L) Magnified X-ray images showed more cancellous bone around the implants by eight weeks (magnification, ×10).
Mentions: All specimens in each group showed a close connection with bone tissues. No low-density shadow of bone absorption was observed in bone tissues (Fig. 5A-K). By eight weeks, more cancellous bone was observed around the implants.

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.