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In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


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Rabbits were euthanized for four weeks postoperatively. (A) The original incision was exposed. No atrophy or secretions were observed around the femurs. (B and C) The prosthesis has a close bonding condition with the medullary cavity. No loosening was seen. (D) No rust was seen on the proximal part of the implant. (E) Calcium salt deposits could be seen in the soft tissues around the proximal part of the prosthesis (stain, hematoxylin and eosin; magnification, ×200). (F) Osteoblasts were observed with no inflammatory response in the surrounding soft tissues (stain, hematoxylin and eosin; magnification, ×400).
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f4-etm-0-0-3472: Rabbits were euthanized for four weeks postoperatively. (A) The original incision was exposed. No atrophy or secretions were observed around the femurs. (B and C) The prosthesis has a close bonding condition with the medullary cavity. No loosening was seen. (D) No rust was seen on the proximal part of the implant. (E) Calcium salt deposits could be seen in the soft tissues around the proximal part of the prosthesis (stain, hematoxylin and eosin; magnification, ×200). (F) Osteoblasts were observed with no inflammatory response in the surrounding soft tissues (stain, hematoxylin and eosin; magnification, ×400).

Mentions: After the rabbits were euthanized, we dissected the tissues around to expose the implants. The results revealed no atrophy or noticeable secretions around the femurs (Fig. 4A). No loosening was observed in all the specimens (Fig. 4B-D). While the top part of the implant was exposed, a close bonding combination was seen between the bone and implant (Fig. 4D). The soft tissue around the top part of the implant was sliced for HE staining observation, and Ca was observed in the soft tissues around, and no obvious inflammation was seen (Fig. 4F).


In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model
Rabbits were euthanized for four weeks postoperatively. (A) The original incision was exposed. No atrophy or secretions were observed around the femurs. (B and C) The prosthesis has a close bonding condition with the medullary cavity. No loosening was seen. (D) No rust was seen on the proximal part of the implant. (E) Calcium salt deposits could be seen in the soft tissues around the proximal part of the prosthesis (stain, hematoxylin and eosin; magnification, ×200). (F) Osteoblasts were observed with no inflammatory response in the surrounding soft tissues (stain, hematoxylin and eosin; magnification, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998353&req=5

f4-etm-0-0-3472: Rabbits were euthanized for four weeks postoperatively. (A) The original incision was exposed. No atrophy or secretions were observed around the femurs. (B and C) The prosthesis has a close bonding condition with the medullary cavity. No loosening was seen. (D) No rust was seen on the proximal part of the implant. (E) Calcium salt deposits could be seen in the soft tissues around the proximal part of the prosthesis (stain, hematoxylin and eosin; magnification, ×200). (F) Osteoblasts were observed with no inflammatory response in the surrounding soft tissues (stain, hematoxylin and eosin; magnification, ×400).
Mentions: After the rabbits were euthanized, we dissected the tissues around to expose the implants. The results revealed no atrophy or noticeable secretions around the femurs (Fig. 4A). No loosening was observed in all the specimens (Fig. 4B-D). While the top part of the implant was exposed, a close bonding combination was seen between the bone and implant (Fig. 4D). The soft tissue around the top part of the implant was sliced for HE staining observation, and Ca was observed in the soft tissues around, and no obvious inflammation was seen (Fig. 4F).

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


Related in: MedlinePlus