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In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

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Related in: MedlinePlus

Surgeries were performed for the specimen implantation. (A) The proximal part of the femur was transected, and the medullary cavity was exposed. Prostheses of (B) 40 and (C) 70% porosity were implanted into the femur. (D) The wound postoperatively.
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f3-etm-0-0-3472: Surgeries were performed for the specimen implantation. (A) The proximal part of the femur was transected, and the medullary cavity was exposed. Prostheses of (B) 40 and (C) 70% porosity were implanted into the femur. (D) The wound postoperatively.

Mentions: The process of the surgical procedure of the specimen implantation was observed (Fig. 3). No fractures and side effects were observed during the operations and for seven days postoperatively.


In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model
Surgeries were performed for the specimen implantation. (A) The proximal part of the femur was transected, and the medullary cavity was exposed. Prostheses of (B) 40 and (C) 70% porosity were implanted into the femur. (D) The wound postoperatively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998353&req=5

f3-etm-0-0-3472: Surgeries were performed for the specimen implantation. (A) The proximal part of the femur was transected, and the medullary cavity was exposed. Prostheses of (B) 40 and (C) 70% porosity were implanted into the femur. (D) The wound postoperatively.
Mentions: The process of the surgical procedure of the specimen implantation was observed (Fig. 3). No fractures and side effects were observed during the operations and for seven days postoperatively.

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


Related in: MedlinePlus