Limits...
In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


Design of the prostheses was based on the morphology, the inner diameter of the femur, and the X-ray observation. (A) The whole-length of the femur was exposed so that the morphology could be observed to inform the design of the prostheses. (B) The upper part of the femur was transected to observe the medullary cavity and measure the inner diameter. (C and D) Anteroposterior and lateral X-rays were obtained for the whole-length femur. The prostheses with (E) 70 and (F) 40% porosity were made as cylindrically shaped in the body with a diameter of 7 mm and a height of 25 mm, and its distal end turned out to be cone-shaped. A hole with a diameter of 1.5 mm was designed on the top part of the specimen so as to be prepared for the pulling-out test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4998353&req=5

f2-etm-0-0-3472: Design of the prostheses was based on the morphology, the inner diameter of the femur, and the X-ray observation. (A) The whole-length of the femur was exposed so that the morphology could be observed to inform the design of the prostheses. (B) The upper part of the femur was transected to observe the medullary cavity and measure the inner diameter. (C and D) Anteroposterior and lateral X-rays were obtained for the whole-length femur. The prostheses with (E) 70 and (F) 40% porosity were made as cylindrically shaped in the body with a diameter of 7 mm and a height of 25 mm, and its distal end turned out to be cone-shaped. A hole with a diameter of 1.5 mm was designed on the top part of the specimen so as to be prepared for the pulling-out test.

Mentions: After dissecting the tissues around the femur, the morphology and the inner diameter of the medullary cavity were observed (Fig. 2A and B). The X-ray was obtained for the whole-length femur (Fig. 2C and D). It showed that the cortex of the lower femoral neck was thick, while the cortex in the femur shaft was loose. According to these characteristics, the prosthesis was designed for a cylindrical shape, with a diameter of 7 mm and a height of 25 mm. Its distal end turns out to be cone-shaped (Fig. 2E and F). A hole with a diameter of 1.5 mm was designed on the top part of the specimen so as to be prepared for the pulling-out test (Fig. 2E and F).


In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model
Design of the prostheses was based on the morphology, the inner diameter of the femur, and the X-ray observation. (A) The whole-length of the femur was exposed so that the morphology could be observed to inform the design of the prostheses. (B) The upper part of the femur was transected to observe the medullary cavity and measure the inner diameter. (C and D) Anteroposterior and lateral X-rays were obtained for the whole-length femur. The prostheses with (E) 70 and (F) 40% porosity were made as cylindrically shaped in the body with a diameter of 7 mm and a height of 25 mm, and its distal end turned out to be cone-shaped. A hole with a diameter of 1.5 mm was designed on the top part of the specimen so as to be prepared for the pulling-out test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998353&req=5

f2-etm-0-0-3472: Design of the prostheses was based on the morphology, the inner diameter of the femur, and the X-ray observation. (A) The whole-length of the femur was exposed so that the morphology could be observed to inform the design of the prostheses. (B) The upper part of the femur was transected to observe the medullary cavity and measure the inner diameter. (C and D) Anteroposterior and lateral X-rays were obtained for the whole-length femur. The prostheses with (E) 70 and (F) 40% porosity were made as cylindrically shaped in the body with a diameter of 7 mm and a height of 25 mm, and its distal end turned out to be cone-shaped. A hole with a diameter of 1.5 mm was designed on the top part of the specimen so as to be prepared for the pulling-out test.
Mentions: After dissecting the tissues around the femur, the morphology and the inner diameter of the medullary cavity were observed (Fig. 2A and B). The X-ray was obtained for the whole-length femur (Fig. 2C and D). It showed that the cortex of the lower femoral neck was thick, while the cortex in the femur shaft was loose. According to these characteristics, the prosthesis was designed for a cylindrical shape, with a diameter of 7 mm and a height of 25 mm. Its distal end turns out to be cone-shaped (Fig. 2E and F). A hole with a diameter of 1.5 mm was designed on the top part of the specimen so as to be prepared for the pulling-out test (Fig. 2E and F).

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.