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In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.


Specimens were prepared for the pulling-out test. (A) Denture powder was used for the fixation of the femurs with prostheses implanted. (B) A pre-prepared hole was designed to have a steel wire crossed into for the upper fixation to the clamp of the mechanical testing machine.
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f1-etm-0-0-3472: Specimens were prepared for the pulling-out test. (A) Denture powder was used for the fixation of the femurs with prostheses implanted. (B) A pre-prepared hole was designed to have a steel wire crossed into for the upper fixation to the clamp of the mechanical testing machine.

Mentions: The samples that contained femurs with porous Ti-25Nb specimens implanted were fixed into the mixture by mixing the denture powder (Fig. 1A) (denture base polymer; Shanghai Beiqiong Tooth Material Co., Ltd., Shanghai, China) with self-curing denture water (methyl methacrylate) in the mold. Care was taken to avoid the denture powder infiltrating into the interface of exposed prosthesis and bone, which may increase the pulling-out strength and affect the accuracy of the observed data. A steel wire was crossed into a hole pre-prepared on the prosthesis for pulling out (Fig. 1B), and it was fixed into the clamp of the mechanical testing machine (3369 Dual-Column Universal Testing System; Instron, Norwood, MA, USA). The distal ends of the specimens were also fixed. The machine's continual displacement of was set to 2 mm/min and underwent pretension for this test. The pulling strength and displacement were recorded automatically using a computer.


In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model
Specimens were prepared for the pulling-out test. (A) Denture powder was used for the fixation of the femurs with prostheses implanted. (B) A pre-prepared hole was designed to have a steel wire crossed into for the upper fixation to the clamp of the mechanical testing machine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998353&req=5

f1-etm-0-0-3472: Specimens were prepared for the pulling-out test. (A) Denture powder was used for the fixation of the femurs with prostheses implanted. (B) A pre-prepared hole was designed to have a steel wire crossed into for the upper fixation to the clamp of the mechanical testing machine.
Mentions: The samples that contained femurs with porous Ti-25Nb specimens implanted were fixed into the mixture by mixing the denture powder (Fig. 1A) (denture base polymer; Shanghai Beiqiong Tooth Material Co., Ltd., Shanghai, China) with self-curing denture water (methyl methacrylate) in the mold. Care was taken to avoid the denture powder infiltrating into the interface of exposed prosthesis and bone, which may increase the pulling-out strength and affect the accuracy of the observed data. A steel wire was crossed into a hole pre-prepared on the prosthesis for pulling out (Fig. 1B), and it was fixed into the clamp of the mechanical testing machine (3369 Dual-Column Universal Testing System; Instron, Norwood, MA, USA). The distal ends of the specimens were also fixed. The machine's continual displacement of was set to 2 mm/min and underwent pretension for this test. The pulling strength and displacement were recorded automatically using a computer.

View Article: PubMed Central - PubMed

ABSTRACT

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.

No MeSH data available.