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Pneumoconiosis increases the risk of congestive heart failure

View Article: PubMed Central - PubMed

ABSTRACT

The purpose of the study was to determine the relationship between pneumoconiosis and congestive heart failure (CHF).

We collected data from the National Health Insurance Research Database in Taiwan. The study sample comprised 8923 patients with pneumoconiosis and 35,692 nonpneumoconiosis controls enrolled from 2000 to 2011. Patients were followed up until the end of 2011 to evaluate the incidence of CHF. The risk of CHF was analyzed using Cox proportional hazard regression models, and the analysis accounted for factors such as sex, age, comorbidities, and air pollutants (μg/m3).

The overall incidence of CHF was higher in the pneumoconiosis cohort (15.7 per 1000 person-y) than in the nonpneumoconiosis cohort (11.2 per 1000 person-y), with a crude hazard ratio (HR) of 1.40 (P < 0.001). The HR for CHF was 1.38-fold greater in the pneumoconiosis cohort than in the nonpneumoconiosis cohort (P < 0.001) after the model was adjusted for age, sex, various comorbidities, and air pollutants (μg/m3). The relative risk for CHF in the sex-specific pneumoconiosis cohort compared with the nonpneumoconiosis cohort was significant for men (adjusted HR = 1.40, 95% confidence interval = 1.21–1.62, P < 0.001). The incidence density rates of CHF increased with age; pneumoconiosis patients had a higher relative risk of CHF for all age group.

Patients with pneumoconiosis were at higher risk for developing CHF than patients in the nonpneumoconiosis cohort, particularly in cases with coexisting coronary artery disease, hypertension, and chronic obstructive pulmonary disease.

No MeSH data available.


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Cumulative incidence of congestive heart failure compared between with and without pneumoconiosis.
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Figure 1: Cumulative incidence of congestive heart failure compared between with and without pneumoconiosis.

Mentions: Table 1 shows the demographic data and comorbidities of patients in the pneumoconiosis and nonpneumoconiosis cohorts. The pneumoconiosis cohort and nonpneumoconiosis cohort exhibited no significant difference in age or sex distributions. Among the pneumoconiosis patients, 82.2% were >60 years and 86.4% were men. The mean age of the pneumoconiosis cohort and nonpneumoconiosis cohort was 66.5 (±7.45) and 66.1 (±8.02) years, respectively. The PM2.5 yearly average of 35.4 μg/m3 for the pneumoconiosis cohort was >28.4 μg/m3 for the nonpneumoconiosis cohort, respectively. The PM10 yearly average of 60.0 μg/m3 for the pneumoconiosis cohort was >50.0 μg/m3 for the nonpneumoconiosis cohort, respectively. Nonpneumoconiosis patients exhibited a higher prevalence of comorbidities (diabetes, hypertension, and hyperlipidemia, but not COPD) than the pneumoconiosis cohort (P < .001). After 12 years of follow-up, the cumulative incidence of CHF in the pneumoconiosis cohort was approximately 4.5% higher than that in the nonpneumoconiosis cohort (P < .001; Fig. 1). During 71,677 and 310,980 person-years of follow-up, the overall incidence density of CHF was significantly higher in the pneumoconiosis cohort than in the nonpneumoconiosis cohort (15.7 vs 11.2 per 1000 person-y), with a crude HR of 1.40 (95% CI = 1.31–1.50) (Table 2).


Pneumoconiosis increases the risk of congestive heart failure
Cumulative incidence of congestive heart failure compared between with and without pneumoconiosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998335&req=5

Figure 1: Cumulative incidence of congestive heart failure compared between with and without pneumoconiosis.
Mentions: Table 1 shows the demographic data and comorbidities of patients in the pneumoconiosis and nonpneumoconiosis cohorts. The pneumoconiosis cohort and nonpneumoconiosis cohort exhibited no significant difference in age or sex distributions. Among the pneumoconiosis patients, 82.2% were >60 years and 86.4% were men. The mean age of the pneumoconiosis cohort and nonpneumoconiosis cohort was 66.5 (±7.45) and 66.1 (±8.02) years, respectively. The PM2.5 yearly average of 35.4 μg/m3 for the pneumoconiosis cohort was >28.4 μg/m3 for the nonpneumoconiosis cohort, respectively. The PM10 yearly average of 60.0 μg/m3 for the pneumoconiosis cohort was >50.0 μg/m3 for the nonpneumoconiosis cohort, respectively. Nonpneumoconiosis patients exhibited a higher prevalence of comorbidities (diabetes, hypertension, and hyperlipidemia, but not COPD) than the pneumoconiosis cohort (P < .001). After 12 years of follow-up, the cumulative incidence of CHF in the pneumoconiosis cohort was approximately 4.5% higher than that in the nonpneumoconiosis cohort (P < .001; Fig. 1). During 71,677 and 310,980 person-years of follow-up, the overall incidence density of CHF was significantly higher in the pneumoconiosis cohort than in the nonpneumoconiosis cohort (15.7 vs 11.2 per 1000 person-y), with a crude HR of 1.40 (95% CI = 1.31–1.50) (Table 2).

View Article: PubMed Central - PubMed

ABSTRACT

The purpose of the study was to determine the relationship between pneumoconiosis and congestive heart failure (CHF).

We collected data from the National Health Insurance Research Database in Taiwan. The study sample comprised 8923 patients with pneumoconiosis and 35,692 nonpneumoconiosis controls enrolled from 2000 to 2011. Patients were followed up until the end of 2011 to evaluate the incidence of CHF. The risk of CHF was analyzed using Cox proportional hazard regression models, and the analysis accounted for factors such as sex, age, comorbidities, and air pollutants (&mu;g/m3).

The overall incidence of CHF was higher in the pneumoconiosis cohort (15.7 per 1000 person-y) than in the nonpneumoconiosis cohort (11.2 per 1000 person-y), with a crude hazard ratio (HR) of 1.40 (P&#8202;&lt;&#8202;0.001). The HR for CHF was 1.38-fold greater in the pneumoconiosis cohort than in the nonpneumoconiosis cohort (P&#8202;&lt;&#8202;0.001) after the model was adjusted for age, sex, various comorbidities, and air pollutants (&mu;g/m3). The relative risk for CHF in the sex-specific pneumoconiosis cohort compared with the nonpneumoconiosis cohort was significant for men (adjusted HR&#8202;=&#8202;1.40, 95% confidence interval&#8202;=&#8202;1.21&ndash;1.62, P&#8202;&lt;&#8202;0.001). The incidence density rates of CHF increased with age; pneumoconiosis patients had a higher relative risk of CHF for all age group.

Patients with pneumoconiosis were at higher risk for developing CHF than patients in the nonpneumoconiosis cohort, particularly in cases with coexisting coronary artery disease, hypertension, and chronic obstructive pulmonary disease.

No MeSH data available.


Related in: MedlinePlus