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Gray matter alterations and correlation of nutritional intake with the gray matter volume in prediabetes

View Article: PubMed Central - PubMed

ABSTRACT

The neurophysiology of prediabetes plays an important role in preventive medicine. The dysregulation of glucose metabolism is likely linked to changes in neuron-related gray matter. Therefore, we designed this study to investigate gray matter alterations in medication-naive prediabetic patients. We expected to find alterations in the gray matter of prediabetic patients.

A total of 64 prediabetic patients and 54 controls were enrolled. All subjects received T1 scans using a 3-T magnetic resonance imaging machine. Subjects also completed nutritional intake records at the 24-hour and 3-day time points to determine their carbohydrate, protein, fat, and total calorie intake. We utilized optimized voxel-based morphometry to estimate the gray matter differences between the patients and controls. In addition, the preprandial serum glucose level and the carbohydrate, protein, fat, and total calorie intake levels were tested to determine whether these parameters were correlated with the gray matter volume.

Prediabetic patients had lower gray matter volumes than controls in the right anterior cingulate gyrus, right posterior cingulate gyrus, left insula, left super temporal gyrus, and left middle temporal gyrus (corrected P < 0.05; voxel threshold: 33). Gray matter volume in the right anterior cingulate was also negatively correlated with the preprandial serum glucose level gyrus in a voxel-dependent manner (r = –0.501; 2-tailed P = 0.001).

The cingulo-temporal and insula gray matter alterations may be associated with the glucose dysregulation in prediabetic patients.

No MeSH data available.


Related in: MedlinePlus

GMV alterations in the right ACC, right PCC (A), left MTG (B), left STG (C), and left insula (D) of prediabetic patients. ACC = anterior cingulate cortex, GMV = gray matter volume, MTG = middle temporal gyrus, PCC = posterior cingulate cortex, STG = superior temporal gyrus.
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Figure 1: GMV alterations in the right ACC, right PCC (A), left MTG (B), left STG (C), and left insula (D) of prediabetic patients. ACC = anterior cingulate cortex, GMV = gray matter volume, MTG = middle temporal gyrus, PCC = posterior cingulate cortex, STG = superior temporal gyrus.

Mentions: The prediabetic patients had lower GMVs in the right anterior cingulate cortex (ACC), the right posterior cingulate cortex (PCC), the left insula, the left super temporal gyrus (STG), and the left middle temporal gyrus (MTG) (Table 2, Fig. 1). The resulting t test images were 1-tailed. No significant increases in the GMV were observed in the prediabetic group compared with the controls. Total GMV was negatively correlated with the serum glucose level (r = –0.501; 2-tailed P = 0.001) and total carbohydrate intake (r = –0.427; 1-tailed P = 0.037), with a correction for the global brain volume, age, and gender of the prediabetic group. In addition, the voxelwise analysis showed that the serum glucose level and total carbohydrate intake were negatively correlated with GMV in the right ACC (corrected P < 0.05; multiple comparisons; cluster size = 40 and 43, respectively).


Gray matter alterations and correlation of nutritional intake with the gray matter volume in prediabetes
GMV alterations in the right ACC, right PCC (A), left MTG (B), left STG (C), and left insula (D) of prediabetic patients. ACC = anterior cingulate cortex, GMV = gray matter volume, MTG = middle temporal gyrus, PCC = posterior cingulate cortex, STG = superior temporal gyrus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998331&req=5

Figure 1: GMV alterations in the right ACC, right PCC (A), left MTG (B), left STG (C), and left insula (D) of prediabetic patients. ACC = anterior cingulate cortex, GMV = gray matter volume, MTG = middle temporal gyrus, PCC = posterior cingulate cortex, STG = superior temporal gyrus.
Mentions: The prediabetic patients had lower GMVs in the right anterior cingulate cortex (ACC), the right posterior cingulate cortex (PCC), the left insula, the left super temporal gyrus (STG), and the left middle temporal gyrus (MTG) (Table 2, Fig. 1). The resulting t test images were 1-tailed. No significant increases in the GMV were observed in the prediabetic group compared with the controls. Total GMV was negatively correlated with the serum glucose level (r = –0.501; 2-tailed P = 0.001) and total carbohydrate intake (r = –0.427; 1-tailed P = 0.037), with a correction for the global brain volume, age, and gender of the prediabetic group. In addition, the voxelwise analysis showed that the serum glucose level and total carbohydrate intake were negatively correlated with GMV in the right ACC (corrected P < 0.05; multiple comparisons; cluster size = 40 and 43, respectively).

View Article: PubMed Central - PubMed

ABSTRACT

The neurophysiology of prediabetes plays an important role in preventive medicine. The dysregulation of glucose metabolism is likely linked to changes in neuron-related gray matter. Therefore, we designed this study to investigate gray matter alterations in medication-naive prediabetic patients. We expected to find alterations in the gray matter of prediabetic patients.

A total of 64 prediabetic patients and 54 controls were enrolled. All subjects received T1 scans using a 3-T magnetic resonance imaging machine. Subjects also completed nutritional intake records at the 24-hour and 3-day time points to determine their carbohydrate, protein, fat, and total calorie intake. We utilized optimized voxel-based morphometry to estimate the gray matter differences between the patients and controls. In addition, the preprandial serum glucose level and the carbohydrate, protein, fat, and total calorie intake levels were tested to determine whether these parameters were correlated with the gray matter volume.

Prediabetic patients had lower gray matter volumes than controls in the right anterior cingulate gyrus, right posterior cingulate gyrus, left insula, left super temporal gyrus, and left middle temporal gyrus (corrected P&#8202;&lt;&#8202;0.05; voxel threshold: 33). Gray matter volume in the right anterior cingulate was also negatively correlated with the preprandial serum glucose level gyrus in a voxel-dependent manner (r&#8202;=&#8202;&ndash;0.501; 2-tailed P&#8202;=&#8202;0.001).

The cingulo-temporal and insula gray matter alterations may be associated with the glucose dysregulation in prediabetic patients.

No MeSH data available.


Related in: MedlinePlus