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Cervical intervertebral disc herniation treatment via radiofrequency combined with low-dose collagenase injection into the disc interior using an anterior cervical approach

View Article: PubMed Central - PubMed

ABSTRACT

This study aimed to determine the therapeutic effect of radiofrequency combined with low-dose collagenase injected into the disc interior via an anterior cervical approach for cervical intervertebral disc herniation.

Forty-three patients (26–62-year old; male/female ratio: 31/12) with cervical intervertebral disc herniation received radiofrequency combined with 60 to 100 U of collagenase, injected via an anterior cervical approach. The degree of nerve function was assessed using the current Japanese Orthopaedic Association (JOA) scoring system at 3 and 12 months postoperation. A visual analogue scale (VAS) was used to evaluate the degree of pain preoperation and 7 days postoperation. The preoperative and 3 month postoperative protrusion areas were measured and compared via magnetic resonance imaging (MRI) and picture archiving and communication systems (PACS).

Compared with the preoperative pain scores, the 7-day postoperative pain was significantly reduced (P <0.01). The excellent and good rates of nerve function amelioration were 93.0% and 90.7% at 3 and 12 months postoperation, respectively, which was not significantly different. Twenty-seven cases exhibited a significantly reduced protrusion area (P <0.01) at 3 months postoperation. No serious side effects were noted.

To our knowledge, this is the first study to demonstrate that the use of radiofrequency combined with low-dose collagenase injection into the disc interior via an anterior cervical approach is effective and safe for the treatment of cervical intervertebral disc herniation.

No MeSH data available.


Related in: MedlinePlus

(A) Protrusion of the C6–7 disc demonstrated via a preoperative magnetic resonance imaging (MRI) scan. (B) Reduced protrusion of the C6–7 disc demonstrated via a postoperative MRI scan.
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Figure 3: (A) Protrusion of the C6–7 disc demonstrated via a preoperative magnetic resonance imaging (MRI) scan. (B) Reduced protrusion of the C6–7 disc demonstrated via a postoperative MRI scan.

Mentions: Table 5 shows the 3 and 12 month postoperative JOA scores, and the overall excellent and good recovery rates were 93.0% and 90.7%, respectively. In addition, the MRI was rechecked at 3 months postoperation in 27 patients (62.8% of all cases), and the protrusions in these cases had diminished or disappeared. Figs. 3–5 show representative MRIs before and after the procedure. The protrusion size was significantly decreased following treatment (P <0.01; Fig. 6). No complications or serious side effects were reported in this study.


Cervical intervertebral disc herniation treatment via radiofrequency combined with low-dose collagenase injection into the disc interior using an anterior cervical approach
(A) Protrusion of the C6–7 disc demonstrated via a preoperative magnetic resonance imaging (MRI) scan. (B) Reduced protrusion of the C6–7 disc demonstrated via a postoperative MRI scan.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998330&req=5

Figure 3: (A) Protrusion of the C6–7 disc demonstrated via a preoperative magnetic resonance imaging (MRI) scan. (B) Reduced protrusion of the C6–7 disc demonstrated via a postoperative MRI scan.
Mentions: Table 5 shows the 3 and 12 month postoperative JOA scores, and the overall excellent and good recovery rates were 93.0% and 90.7%, respectively. In addition, the MRI was rechecked at 3 months postoperation in 27 patients (62.8% of all cases), and the protrusions in these cases had diminished or disappeared. Figs. 3–5 show representative MRIs before and after the procedure. The protrusion size was significantly decreased following treatment (P <0.01; Fig. 6). No complications or serious side effects were reported in this study.

View Article: PubMed Central - PubMed

ABSTRACT

This study aimed to determine the therapeutic effect of radiofrequency combined with low-dose collagenase injected into the disc interior via an anterior cervical approach for cervical intervertebral disc herniation.

Forty-three patients (26&ndash;62-year old; male/female ratio: 31/12) with cervical intervertebral disc herniation received radiofrequency combined with 60 to 100 U of collagenase, injected via an anterior cervical approach. The degree of nerve function was assessed using the current Japanese Orthopaedic Association (JOA) scoring system at 3 and 12 months postoperation. A visual analogue scale (VAS) was used to evaluate the degree of pain preoperation and 7 days postoperation. The preoperative and 3 month postoperative protrusion areas were measured and compared via magnetic resonance imaging (MRI) and picture archiving and communication systems (PACS).

Compared with the preoperative pain scores, the 7-day postoperative pain was significantly reduced (P&#8202;&lt;0.01). The excellent and good rates of nerve function amelioration were 93.0% and 90.7% at 3 and 12 months postoperation, respectively, which was not significantly different. Twenty-seven cases exhibited a significantly reduced protrusion area (P&#8202;&lt;0.01) at 3 months postoperation. No serious side effects were noted.

To our knowledge, this is the first study to demonstrate that the use of radiofrequency combined with low-dose collagenase injection into the disc interior via an anterior cervical approach is effective and safe for the treatment of cervical intervertebral disc herniation.

No MeSH data available.


Related in: MedlinePlus