Limits...
Cervical intervertebral disc herniation treatment via radiofrequency combined with low-dose collagenase injection into the disc interior using an anterior cervical approach

View Article: PubMed Central - PubMed

ABSTRACT

This study aimed to determine the therapeutic effect of radiofrequency combined with low-dose collagenase injected into the disc interior via an anterior cervical approach for cervical intervertebral disc herniation.

Forty-three patients (26–62-year old; male/female ratio: 31/12) with cervical intervertebral disc herniation received radiofrequency combined with 60 to 100 U of collagenase, injected via an anterior cervical approach. The degree of nerve function was assessed using the current Japanese Orthopaedic Association (JOA) scoring system at 3 and 12 months postoperation. A visual analogue scale (VAS) was used to evaluate the degree of pain preoperation and 7 days postoperation. The preoperative and 3 month postoperative protrusion areas were measured and compared via magnetic resonance imaging (MRI) and picture archiving and communication systems (PACS).

Compared with the preoperative pain scores, the 7-day postoperative pain was significantly reduced (P <0.01). The excellent and good rates of nerve function amelioration were 93.0% and 90.7% at 3 and 12 months postoperation, respectively, which was not significantly different. Twenty-seven cases exhibited a significantly reduced protrusion area (P <0.01) at 3 months postoperation. No serious side effects were noted.

To our knowledge, this is the first study to demonstrate that the use of radiofrequency combined with low-dose collagenase injection into the disc interior via an anterior cervical approach is effective and safe for the treatment of cervical intervertebral disc herniation.

No MeSH data available.


Related in: MedlinePlus

Protrusion area was measured and compared using magnetic resonance imaging and picture archiving and communication systems.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4998330&req=5

Figure 2: Protrusion area was measured and compared using magnetic resonance imaging and picture archiving and communication systems.

Mentions: Preoperative and 7 day postoperative pain was evaluated using a visual analogue scale (VAS), in which 0 indicated no pain and 10 indicted unbearable pain. The Japanese Orthopaedic Association (JOA) Score[10] was used to evaluate the recovery rate of the neurological function at 3 and 12 months after the operation. This scale consists of 6 domain scores (motor dysfunction in the upper extremities, motor dysfunction in the lower extremities, sensory function in the upper extremities, sensory function in the trunk, sensory function in the lower extremities, and bladder function), which are scored from 0 to 4, 4, 2, 2, 2, and 3, respectively. The minimum total score is 0, and the maximum total score is 17. The recovery rate was calculated using the following equation: recovery rate = [(JOA score at follow-up – preoperative JOA score)/(17 – preoperative JOA score)] × 100%. Based on the recovery rate, outcomes were classified into 4 grades: excellent (75–100%), good (50–74%), ordinary (25–49%), and poor (<25%). The preoperative and 3 month postoperative protrusion areas were measured and compared using MRI and picture archiving and communication systems (PACS; Sharp ke Asia Pacific Investment Management (Shanghai) Co, LTD, Shanghai, China). The same technical personnel performed all measurements, and the axial maximum protrusion area on the MR images was selected to calculate the area values via PACS automatic measurements (Fig. 2).


Cervical intervertebral disc herniation treatment via radiofrequency combined with low-dose collagenase injection into the disc interior using an anterior cervical approach
Protrusion area was measured and compared using magnetic resonance imaging and picture archiving and communication systems.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998330&req=5

Figure 2: Protrusion area was measured and compared using magnetic resonance imaging and picture archiving and communication systems.
Mentions: Preoperative and 7 day postoperative pain was evaluated using a visual analogue scale (VAS), in which 0 indicated no pain and 10 indicted unbearable pain. The Japanese Orthopaedic Association (JOA) Score[10] was used to evaluate the recovery rate of the neurological function at 3 and 12 months after the operation. This scale consists of 6 domain scores (motor dysfunction in the upper extremities, motor dysfunction in the lower extremities, sensory function in the upper extremities, sensory function in the trunk, sensory function in the lower extremities, and bladder function), which are scored from 0 to 4, 4, 2, 2, 2, and 3, respectively. The minimum total score is 0, and the maximum total score is 17. The recovery rate was calculated using the following equation: recovery rate = [(JOA score at follow-up – preoperative JOA score)/(17 – preoperative JOA score)] × 100%. Based on the recovery rate, outcomes were classified into 4 grades: excellent (75–100%), good (50–74%), ordinary (25–49%), and poor (<25%). The preoperative and 3 month postoperative protrusion areas were measured and compared using MRI and picture archiving and communication systems (PACS; Sharp ke Asia Pacific Investment Management (Shanghai) Co, LTD, Shanghai, China). The same technical personnel performed all measurements, and the axial maximum protrusion area on the MR images was selected to calculate the area values via PACS automatic measurements (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

This study aimed to determine the therapeutic effect of radiofrequency combined with low-dose collagenase injected into the disc interior via an anterior cervical approach for cervical intervertebral disc herniation.

Forty-three patients (26&ndash;62-year old; male/female ratio: 31/12) with cervical intervertebral disc herniation received radiofrequency combined with 60 to 100 U of collagenase, injected via an anterior cervical approach. The degree of nerve function was assessed using the current Japanese Orthopaedic Association (JOA) scoring system at 3 and 12 months postoperation. A visual analogue scale (VAS) was used to evaluate the degree of pain preoperation and 7 days postoperation. The preoperative and 3 month postoperative protrusion areas were measured and compared via magnetic resonance imaging (MRI) and picture archiving and communication systems (PACS).

Compared with the preoperative pain scores, the 7-day postoperative pain was significantly reduced (P&#8202;&lt;0.01). The excellent and good rates of nerve function amelioration were 93.0% and 90.7% at 3 and 12 months postoperation, respectively, which was not significantly different. Twenty-seven cases exhibited a significantly reduced protrusion area (P&#8202;&lt;0.01) at 3 months postoperation. No serious side effects were noted.

To our knowledge, this is the first study to demonstrate that the use of radiofrequency combined with low-dose collagenase injection into the disc interior via an anterior cervical approach is effective and safe for the treatment of cervical intervertebral disc herniation.

No MeSH data available.


Related in: MedlinePlus