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Different lymph node staging systems in patients with gastric cancer from Korean

View Article: PubMed Central - PubMed

ABSTRACT

To investigate whether the log odds of positive lymph nodes (LODDS) system is a more accurate prognostic tool than the number-based (pN) or ratio-based (rN) lymph node staging system in Korean patients with gastric cancer (GC).

The LODDS is a recently proposed staging modality in surgical oncology. However, it is unclear whether LODDS is superior to the pN or rN system in terms of predicting the prognosis of GC patients who underwent radical gastrectomy with extended lymphadenectomy and had a greater number of retrieved lymph nodes.

Clinicopathological data from 3929 patients who had undergone curative gastrectomy for GC were reviewed. In addition, overall survival rates according to pN and rN classification stratified by the LODDS were analyzed. A multivariate analysis of survival rate was performed using a Cox proportional hazard model.

pN, rN, and LODDS were significantly correlated with 5-year survival rate. Spearman correlation test showed no correlation between LODDS and number of lymph nodes retrieved. The receiver operating characteristic (ROC) curves showed that the 3 staging systems had comparable prognostic accuracy (P < 0.05). Survival analysis according to pN and rN classification stratified by the LODDS staging system demonstrated that LODDS is superior to pN and rN.

The LODDS is independently and significantly associated with the OS of Korean patients with GC, and its prognostic value is superior to that of the other lymph node staging systems in Korean patients.

No MeSH data available.


ROC curves of pN, rN, and LODDS for predicting survival. LODDS = log odds of positive lymph nodes, pN = pathologic nodal, rN = lymph node ratio, ROC = receiver operating characteristic.
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Figure 2: ROC curves of pN, rN, and LODDS for predicting survival. LODDS = log odds of positive lymph nodes, pN = pathologic nodal, rN = lymph node ratio, ROC = receiver operating characteristic.

Mentions: Table 5 shows 5-year survival rates according to pN and rN classification stratified by LODDS. When stratified by the LODDS system, significant differences in survival were observed among patients in each pN and rN stage, with the exception of rN2. However, for patients with LODDS 4, survival rates were not homogenous when stratified by pN and rN classifications. The corresponding areas under the curve (AUC) for pN, rN, and LODDS were 0.728 (95% CI 0.709–0.747), 0.732 (95% CI 0.713–0.751), and 0.746 (95% CI 0.727–0.746), respectively, with no significant differences (P > 0.05) (Fig. 2).


Different lymph node staging systems in patients with gastric cancer from Korean
ROC curves of pN, rN, and LODDS for predicting survival. LODDS = log odds of positive lymph nodes, pN = pathologic nodal, rN = lymph node ratio, ROC = receiver operating characteristic.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998309&req=5

Figure 2: ROC curves of pN, rN, and LODDS for predicting survival. LODDS = log odds of positive lymph nodes, pN = pathologic nodal, rN = lymph node ratio, ROC = receiver operating characteristic.
Mentions: Table 5 shows 5-year survival rates according to pN and rN classification stratified by LODDS. When stratified by the LODDS system, significant differences in survival were observed among patients in each pN and rN stage, with the exception of rN2. However, for patients with LODDS 4, survival rates were not homogenous when stratified by pN and rN classifications. The corresponding areas under the curve (AUC) for pN, rN, and LODDS were 0.728 (95% CI 0.709–0.747), 0.732 (95% CI 0.713–0.751), and 0.746 (95% CI 0.727–0.746), respectively, with no significant differences (P > 0.05) (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

To investigate whether the log odds of positive lymph nodes (LODDS) system is a more accurate prognostic tool than the number-based (pN) or ratio-based (rN) lymph node staging system in Korean patients with gastric cancer (GC).

The LODDS is a recently proposed staging modality in surgical oncology. However, it is unclear whether LODDS is superior to the pN or rN system in terms of predicting the prognosis of GC patients who underwent radical gastrectomy with extended lymphadenectomy and had a greater number of retrieved lymph nodes.

Clinicopathological data from 3929 patients who had undergone curative gastrectomy for GC were reviewed. In addition, overall survival rates according to pN and rN classification stratified by the LODDS were analyzed. A multivariate analysis of survival rate was performed using a Cox proportional hazard model.

pN, rN, and LODDS were significantly correlated with 5-year survival rate. Spearman correlation test showed no correlation between LODDS and number of lymph nodes retrieved. The receiver operating characteristic (ROC) curves showed that the 3 staging systems had comparable prognostic accuracy (P < 0.05). Survival analysis according to pN and rN classification stratified by the LODDS staging system demonstrated that LODDS is superior to pN and rN.

The LODDS is independently and significantly associated with the OS of Korean patients with GC, and its prognostic value is superior to that of the other lymph node staging systems in Korean patients.

No MeSH data available.