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Primary malignant melanoma of the esophagus treated by endoscopic submucosal dissection: A case report

View Article: PubMed Central - PubMed

ABSTRACT

Primary malignant melanoma of the esophagus (PMME) is a rare malignant neoplasm of the esophagus. In the majority of cases, the disease originates in the mucosal layer of the esophagus, which is similar to other types of esophageal cancer. With the development of endoscopic submucosal dissection (ESD), endoscopic resection is possible for cases in which melanomas are limited to the mucosal and submucosal layer. However, few studies report the efficiency of ESD for PMME, and no studies perform long-term follow-up. The present study reported the case of a 71-year-old PMME patient who was successfully treated by ESD at The Third Affiliated Hospital of Soochow University (Changzhou, China) in Otober 2011, with a follow-up of >3 years conducted.

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(A) Large artificial ulcer created following endoscopic submucosal dissection. (B) Specimen resected from the patient (size, 2.5×2.8 cm).
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f2-etm-0-0-3482: (A) Large artificial ulcer created following endoscopic submucosal dissection. (B) Specimen resected from the patient (size, 2.5×2.8 cm).

Mentions: A 71-year-old female patient was admitted to the Third Affiliated Hospital of Soochow University with complaints of progressive dysphagia in December 2011. The patient had been diagnosed with breast carcinoma and had undergone radical surgery >2 years earlier. Physical examination was normal and revealed no skin lesions. Esophagogastroscopy indicated an irregularly shaped pigmented polypoid mass located between 29 and 32 cm from the incisors (Fig. 1A). Biopsy was performed and the mass was found to be a primary malignant melanoma. In addition, endoscopic ultrasound (EUS) was performed and indicated a hyperechoic mass originating from the mucosal layer, which was 0.8×2.8 cm in size with a pedicle diameter of ~0.8 cm (Fig. 1B). The mass originated from the mucosal layer and displayed a tubiform structure in the center with no echo, while the submucosal layer and muscularis propria were intact. Chest and abdominal computerized tomography (CT) indicated no metastasis to the lymph nodes, mediastinum or the lungs. Further examinations also ruled out distant metastasis. Additionally, the patient declined surgery for the PMME, and was thus treated with ESD (Fig. 2), subsequent to providing informed consent.


Primary malignant melanoma of the esophagus treated by endoscopic submucosal dissection: A case report
(A) Large artificial ulcer created following endoscopic submucosal dissection. (B) Specimen resected from the patient (size, 2.5×2.8 cm).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998296&req=5

f2-etm-0-0-3482: (A) Large artificial ulcer created following endoscopic submucosal dissection. (B) Specimen resected from the patient (size, 2.5×2.8 cm).
Mentions: A 71-year-old female patient was admitted to the Third Affiliated Hospital of Soochow University with complaints of progressive dysphagia in December 2011. The patient had been diagnosed with breast carcinoma and had undergone radical surgery >2 years earlier. Physical examination was normal and revealed no skin lesions. Esophagogastroscopy indicated an irregularly shaped pigmented polypoid mass located between 29 and 32 cm from the incisors (Fig. 1A). Biopsy was performed and the mass was found to be a primary malignant melanoma. In addition, endoscopic ultrasound (EUS) was performed and indicated a hyperechoic mass originating from the mucosal layer, which was 0.8×2.8 cm in size with a pedicle diameter of ~0.8 cm (Fig. 1B). The mass originated from the mucosal layer and displayed a tubiform structure in the center with no echo, while the submucosal layer and muscularis propria were intact. Chest and abdominal computerized tomography (CT) indicated no metastasis to the lymph nodes, mediastinum or the lungs. Further examinations also ruled out distant metastasis. Additionally, the patient declined surgery for the PMME, and was thus treated with ESD (Fig. 2), subsequent to providing informed consent.

View Article: PubMed Central - PubMed

ABSTRACT

Primary malignant melanoma of the esophagus (PMME) is a rare malignant neoplasm of the esophagus. In the majority of cases, the disease originates in the mucosal layer of the esophagus, which is similar to other types of esophageal cancer. With the development of endoscopic submucosal dissection (ESD), endoscopic resection is possible for cases in which melanomas are limited to the mucosal and submucosal layer. However, few studies report the efficiency of ESD for PMME, and no studies perform long-term follow-up. The present study reported the case of a 71-year-old PMME patient who was successfully treated by ESD at The Third Affiliated Hospital of Soochow University (Changzhou, China) in Otober 2011, with a follow-up of >3 years conducted.

No MeSH data available.


Related in: MedlinePlus