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Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning

View Article: PubMed Central - PubMed

ABSTRACT

Carbon monoxide (CO) poisoning may cause toxicity of the central nervous system and heart. However, the association between CO poisoning and long-term dementia risk remains unestablished. We investigated the incidence of dementia in patients with CO poisoning in Taiwan and evaluated whether they had a higher risk of dementia than did the general population.

A nationwide population-based cohort study was conducted among patients with CO poisoning identified using Taiwan's National Health Insurance Research Database (NHIRD) during 2004 to 2013. CO poisoning was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes. The study cohort comprised patients with CO poisoning between 2005 and 2010 (N = 14,590). Each patient was age-, sex-, and index date-matched with 4 randomly selected controls from the comparison cohort (N = 58,360). All patients were followed from the study date until dementia development, death, or the end of 2013. Cox proportional hazards regressions were performed for comparing the hazard ratios for dementia between the 2 cohorts.

Incident cases of dementia were identified from the NHIRD.

After adjustment for potential confounders, the study cohort was independently associated with a higher dementia risk (adjusted hazard ratio, 2.75; 95% confidence interval, 2.26–3.35).

This population-based cohort study indicated that patients with CO poisoning have a higher risk of dementia than do people without CO poisoning.

No MeSH data available.


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Plot of dementia hazard curves based on the Cox model analysis for patients with carbon monoxide intoxication and comparison cohort.
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Figure 1: Plot of dementia hazard curves based on the Cox model analysis for patients with carbon monoxide intoxication and comparison cohort.

Mentions: Sensitivity analysis results obtained using the Cox proportional hazards regression model for examining the risk of dementia after CO poisoning are shown in Table 3. We performed sensitivity analysis after excluding patients diagnosed with dementia <1 to 2 years after CO poisoning. The association between CO poisoning and dementia remained consistent. Kaplan–Meier analysis revealed survival curves based on the Cox proportional hazards regression model for the cumulative incidence of dementia in the study and comparison cohorts during the mean 5-year follow-up period. The cumulative incidence of dementia during the follow-up for the study cohort was significantly higher than that for the comparison cohort (P < 0.001; Figure 1).


Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning
Plot of dementia hazard curves based on the Cox model analysis for patients with carbon monoxide intoxication and comparison cohort.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998278&req=5

Figure 1: Plot of dementia hazard curves based on the Cox model analysis for patients with carbon monoxide intoxication and comparison cohort.
Mentions: Sensitivity analysis results obtained using the Cox proportional hazards regression model for examining the risk of dementia after CO poisoning are shown in Table 3. We performed sensitivity analysis after excluding patients diagnosed with dementia <1 to 2 years after CO poisoning. The association between CO poisoning and dementia remained consistent. Kaplan–Meier analysis revealed survival curves based on the Cox proportional hazards regression model for the cumulative incidence of dementia in the study and comparison cohorts during the mean 5-year follow-up period. The cumulative incidence of dementia during the follow-up for the study cohort was significantly higher than that for the comparison cohort (P < 0.001; Figure 1).

View Article: PubMed Central - PubMed

ABSTRACT

Carbon monoxide (CO) poisoning may cause toxicity of the central nervous system and heart. However, the association between CO poisoning and long-term dementia risk remains unestablished. We investigated the incidence of dementia in patients with CO poisoning in Taiwan and evaluated whether they had a higher risk of dementia than did the general population.

A nationwide population-based cohort study was conducted among patients with CO poisoning identified using Taiwan's National Health Insurance Research Database (NHIRD) during 2004 to 2013. CO poisoning was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes. The study cohort comprised patients with CO poisoning between 2005 and 2010 (N&#8202;=&#8202;14,590). Each patient was age-, sex-, and index date-matched with 4 randomly selected controls from the comparison cohort (N&#8202;=&#8202;58,360). All patients were followed from the study date until dementia development, death, or the end of 2013. Cox proportional hazards regressions were performed for comparing the hazard ratios for dementia between the 2 cohorts.

Incident cases of dementia were identified from the NHIRD.

After adjustment for potential confounders, the study cohort was independently associated with a higher dementia risk (adjusted hazard ratio, 2.75; 95% confidence interval, 2.26&ndash;3.35).

This population-based cohort study indicated that patients with CO poisoning have a higher risk of dementia than do people without CO poisoning.

No MeSH data available.


Related in: MedlinePlus