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HPV strain distribution in patients with genital warts in a female population sample

View Article: PubMed Central - PubMed

ABSTRACT

The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high- and low-risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. In total, we detected 37 anogenital HPV DNA genotypes [6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39 and CP6108] and investigated the incidence of these genotypes in the patients with genital warts. We found differences in the distribution of high-/low-risk strains and the incidence of high-risk strains was found to occur mainly in females under 35 years of age. The data from our study suggest that a detailed oral, rectal and genital identification of high-risk strains should be performed to visualize the entire pattern of possible triggers of carcinogenesis.

No MeSH data available.


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Age distribution among human papillomavirus high-risk strains.
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f3-ol-0-0-4903: Age distribution among human papillomavirus high-risk strains.

Mentions: When assessing the age distribution of all the tested female patients (Fig. 2), we found that as regards the mean age of the low- and high-risk female patient groups, there was no statistically significant difference, while in the group that tested negative there is a clear-cut increase as in mean age. When examining the statistical significance as regards the predisposition for cancer associated with high-risk HPV in terms of female age (Fig. 3) we observed that there was a clear tendency towards the high-risk HPV strains in patients <35 years of age, with no actual preponderance among the different high-risk strains.


HPV strain distribution in patients with genital warts in a female population sample
Age distribution among human papillomavirus high-risk strains.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998207&req=5

f3-ol-0-0-4903: Age distribution among human papillomavirus high-risk strains.
Mentions: When assessing the age distribution of all the tested female patients (Fig. 2), we found that as regards the mean age of the low- and high-risk female patient groups, there was no statistically significant difference, while in the group that tested negative there is a clear-cut increase as in mean age. When examining the statistical significance as regards the predisposition for cancer associated with high-risk HPV in terms of female age (Fig. 3) we observed that there was a clear tendency towards the high-risk HPV strains in patients <35 years of age, with no actual preponderance among the different high-risk strains.

View Article: PubMed Central - PubMed

ABSTRACT

The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high- and low-risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. In total, we detected 37 anogenital HPV DNA genotypes [6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39 and CP6108] and investigated the incidence of these genotypes in the patients with genital warts. We found differences in the distribution of high-/low-risk strains and the incidence of high-risk strains was found to occur mainly in females under 35 years of age. The data from our study suggest that a detailed oral, rectal and genital identification of high-risk strains should be performed to visualize the entire pattern of possible triggers of carcinogenesis.

No MeSH data available.


Related in: MedlinePlus