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High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome

View Article: PubMed Central - PubMed

ABSTRACT

Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize PAMS. The most common symptoms of PAMS include pain associated with continuous oral ulceration and resistance to pharmacological treatment. The present study reports the case of a 42-year-old female patient who was admitted with an 8-month history of erosive skin lesions within the trunk region, oral mucosa and vaginal mucosa. The patient was diagnosed with PAMS based on computed tomography scans and histological analyses of the lesions. The lymphoid hyperplasia in the retroperitoneum and lesions in the vaginal mucosa and trunk area were improved following pharmacological treatment and resection of the lymph node showing hyperplasia. However, the oral lesion was treated with intraluminal brachytherapy due to its resistance to long-term pharmacological treatment. The majority of the lesions were improved following treatment, in the absence of any severe side effects. In addition, neither worsening nor progression of the oral lesion was observed during the 4-year follow-up period.

No MeSH data available.


Oral lesion following brachytherapy. The majority of the lesions on the tongue had disappeared by the end of the brachytherapy, and aggravation of the disease was not observed during the 4-year follow-up period.
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f5-etm-0-0-3458: Oral lesion following brachytherapy. The majority of the lesions on the tongue had disappeared by the end of the brachytherapy, and aggravation of the disease was not observed during the 4-year follow-up period.

Mentions: Grade 2 radiation-induced oral mucositis (9) was observed during the treatment. Chronic side effects were not observed during the follow-up period and the majority of the tongue lesions were successfully treated following brachytherapy (Fig. 5). No disease progression was observed during the 4-year follow-up period; the patient's oral disease lesions completely healed.


High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome
Oral lesion following brachytherapy. The majority of the lesions on the tongue had disappeared by the end of the brachytherapy, and aggravation of the disease was not observed during the 4-year follow-up period.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998192&req=5

f5-etm-0-0-3458: Oral lesion following brachytherapy. The majority of the lesions on the tongue had disappeared by the end of the brachytherapy, and aggravation of the disease was not observed during the 4-year follow-up period.
Mentions: Grade 2 radiation-induced oral mucositis (9) was observed during the treatment. Chronic side effects were not observed during the follow-up period and the majority of the tongue lesions were successfully treated following brachytherapy (Fig. 5). No disease progression was observed during the 4-year follow-up period; the patient's oral disease lesions completely healed.

View Article: PubMed Central - PubMed

ABSTRACT

Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize PAMS. The most common symptoms of PAMS include pain associated with continuous oral ulceration and resistance to pharmacological treatment. The present study reports the case of a 42-year-old female patient who was admitted with an 8-month history of erosive skin lesions within the trunk region, oral mucosa and vaginal mucosa. The patient was diagnosed with PAMS based on computed tomography scans and histological analyses of the lesions. The lymphoid hyperplasia in the retroperitoneum and lesions in the vaginal mucosa and trunk area were improved following pharmacological treatment and resection of the lymph node showing hyperplasia. However, the oral lesion was treated with intraluminal brachytherapy due to its resistance to long-term pharmacological treatment. The majority of the lesions were improved following treatment, in the absence of any severe side effects. In addition, neither worsening nor progression of the oral lesion was observed during the 4-year follow-up period.

No MeSH data available.