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miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression

View Article: PubMed Central - PubMed

ABSTRACT

Increasing evidence has shown that microRNA (miRNA) is extensively involved in the pathophysiology of lung cancer. Microarray data demonstrated the increasing levels of miR-19a in the peripheral blood from patients suffering from lung cancer, which is closely associated with poor prognosis of lung cancer. However, the underlying molecular mechanism of miR-19a remains to be determined. The results of the present study showed a higher expression of miR-19a compared with normal bronchial epithelial cells. Furthermore, lentivirus vectors were constructed to establish cell lines that overexpressed and knocked out miR-19a in order to study the role of miR-19a on the metastasis and proliferation of lung cancer cells. Investigation into the underlying mechanism of miR-19a, revealed that MXD1 may be the key gene targeting miR-19a, participating in the process of proliferation and metastasis of lung cancer cells.

No MeSH data available.


miR-19a expression in the H460, H1299 and BEAS-2B cell lines. ***P<0.05, statistically signifiicant.
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f1-ol-0-0-4881: miR-19a expression in the H460, H1299 and BEAS-2B cell lines. ***P<0.05, statistically signifiicant.

Mentions: RT-PCR was used to detect the expression of miR-19a in lung cancer and normal cells to determine the association between miR-19a and lung cancer. The results showed a significant difference between the normal and lung cancer cells (Fig. 1).


miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression
miR-19a expression in the H460, H1299 and BEAS-2B cell lines. ***P<0.05, statistically signifiicant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998008&req=5

f1-ol-0-0-4881: miR-19a expression in the H460, H1299 and BEAS-2B cell lines. ***P<0.05, statistically signifiicant.
Mentions: RT-PCR was used to detect the expression of miR-19a in lung cancer and normal cells to determine the association between miR-19a and lung cancer. The results showed a significant difference between the normal and lung cancer cells (Fig. 1).

View Article: PubMed Central - PubMed

ABSTRACT

Increasing evidence has shown that microRNA (miRNA) is extensively involved in the pathophysiology of lung cancer. Microarray data demonstrated the increasing levels of miR-19a in the peripheral blood from patients suffering from lung cancer, which is closely associated with poor prognosis of lung cancer. However, the underlying molecular mechanism of miR-19a remains to be determined. The results of the present study showed a higher expression of miR-19a compared with normal bronchial epithelial cells. Furthermore, lentivirus vectors were constructed to establish cell lines that overexpressed and knocked out miR-19a in order to study the role of miR-19a on the metastasis and proliferation of lung cancer cells. Investigation into the underlying mechanism of miR-19a, revealed that MXD1 may be the key gene targeting miR-19a, participating in the process of proliferation and metastasis of lung cancer cells.

No MeSH data available.