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3D-DIR for early differential diagnostic and prognostic evaluation of NMO

View Article: PubMed Central - PubMed

ABSTRACT

Neuromyelitis optica (NMO) is an acute or subacute lesion of demyelinating disease involving the optic nerve and spinal cord, and imaging techniques and their effects have been the focus of investigations. The aim of the present study was to examine the value of three-dimensional double inversion recovery (3D-DIR) in the early differential diagnostic and prognostic evaluation of NMO. Forty-eight patients with suspicious NMO were included into the study and underwent a combination of serum NMO-IgG quantitative detection and 3D-DIR examination. Forty cases (83.3%) of the suspicious cases were confirmed with NMO. The average time from onset to definite diagnosis was 3.5±0.6 days. The brain showed high T2W and fluid-attenuated inversion recovery (FLAIR) signals, involving 5.8±1.2 sites on average, distributed in the peripheral lateral ventricle, medulla, cerebral white matter, the third ventricle, peripheral aqueduct of sylvius, pons and diencephalon. The average T2W signal strength was 2.73±0.12. The signal intensity of DIR was significantly higher than that of T2W and FLAIR, and the difference was statistically significant. The optic nerve and chiasma showed a high FLAIR signal, with an average signal intensity of 2.13±0.14. The spinal cord showed swelling, necrosis and cavity lesion, involving the gray and white matter of the central site, transversely, with an average lesion length of 4.7±0.6 centrum. The relative signal intensity of DIR was significantly higher than that of T2W and FLAIR. Following treatment, the signal intensity of the brain, optic nerve, optic chiasma and spinal cord decreased significantly (P<0.05). In conclusion, 3D-DIR has great application value in the early differential diagnostic and prognostic evaluation of NMO.

No MeSH data available.


(A) Optic chiasma showed high FLAIR signal with an average signal intensity of 2.13±0.14. (B and C) DIR transverse and coronal view shows higher signals with an average signal intensity of 2.37±0.23. FLAIR, fluid-attenuated inversion recovery; DIR, double inversion recovery.
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f1-etm-0-0-3474: (A) Optic chiasma showed high FLAIR signal with an average signal intensity of 2.13±0.14. (B and C) DIR transverse and coronal view shows higher signals with an average signal intensity of 2.37±0.23. FLAIR, fluid-attenuated inversion recovery; DIR, double inversion recovery.

Mentions: The brain of NMO patients showed low T1W signal, high T2W and FLAIR signals, involving 5.8±1.2 sites on average, and being distributed in the peripheral lateral ventricle, medulla, cerebral white matter, the third ventricle, peripheral aqueduct of sylvius, pons and diencephalon. The average T2W signal strength was 2.73±0.12, average FLAIR signal strength was 2.56±0.23 and the average DIR signal strength was 2.89±0.32. The signal intensity of T2W, FLAIR and DIR of NMO patients was significantly higher than that of MS patients, with the average sites involved being more than those of MS patients (P<0.05) (Table I and Fig. 1).


3D-DIR for early differential diagnostic and prognostic evaluation of NMO
(A) Optic chiasma showed high FLAIR signal with an average signal intensity of 2.13±0.14. (B and C) DIR transverse and coronal view shows higher signals with an average signal intensity of 2.37±0.23. FLAIR, fluid-attenuated inversion recovery; DIR, double inversion recovery.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4998000&req=5

f1-etm-0-0-3474: (A) Optic chiasma showed high FLAIR signal with an average signal intensity of 2.13±0.14. (B and C) DIR transverse and coronal view shows higher signals with an average signal intensity of 2.37±0.23. FLAIR, fluid-attenuated inversion recovery; DIR, double inversion recovery.
Mentions: The brain of NMO patients showed low T1W signal, high T2W and FLAIR signals, involving 5.8±1.2 sites on average, and being distributed in the peripheral lateral ventricle, medulla, cerebral white matter, the third ventricle, peripheral aqueduct of sylvius, pons and diencephalon. The average T2W signal strength was 2.73±0.12, average FLAIR signal strength was 2.56±0.23 and the average DIR signal strength was 2.89±0.32. The signal intensity of T2W, FLAIR and DIR of NMO patients was significantly higher than that of MS patients, with the average sites involved being more than those of MS patients (P<0.05) (Table I and Fig. 1).

View Article: PubMed Central - PubMed

ABSTRACT

Neuromyelitis optica (NMO) is an acute or subacute lesion of demyelinating disease involving the optic nerve and spinal cord, and imaging techniques and their effects have been the focus of investigations. The aim of the present study was to examine the value of three-dimensional double inversion recovery (3D-DIR) in the early differential diagnostic and prognostic evaluation of NMO. Forty-eight patients with suspicious NMO were included into the study and underwent a combination of serum NMO-IgG quantitative detection and 3D-DIR examination. Forty cases (83.3%) of the suspicious cases were confirmed with NMO. The average time from onset to definite diagnosis was 3.5&plusmn;0.6 days. The brain showed high T2W and fluid-attenuated inversion recovery (FLAIR) signals, involving 5.8&plusmn;1.2 sites on average, distributed in the peripheral lateral ventricle, medulla, cerebral white matter, the third ventricle, peripheral aqueduct of sylvius, pons and diencephalon. The average T2W signal strength was 2.73&plusmn;0.12. The signal intensity of DIR was significantly higher than that of T2W and FLAIR, and the difference was statistically significant. The optic nerve and chiasma showed a high FLAIR signal, with an average signal intensity of 2.13&plusmn;0.14. The spinal cord showed swelling, necrosis and cavity lesion, involving the gray and white matter of the central site, transversely, with an average lesion length of 4.7&plusmn;0.6 centrum. The relative signal intensity of DIR was significantly higher than that of T2W and FLAIR. Following treatment, the signal intensity of the brain, optic nerve, optic chiasma and spinal cord decreased significantly (P&lt;0.05). In conclusion, 3D-DIR has great application value in the early differential diagnostic and prognostic evaluation of NMO.

No MeSH data available.