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Control of Risk Factors for Cardiovascular Disease among Multinational Patient Population in the Arabian Gulf

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ABSTRACT

We evaluated the control of cardiovascular disease (CVD) risk factors among patients with atherosclerotic cardiovascular disease (ASCVD) in the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolaemia (CEPHEUS) in the Arabian Gulf. Of the 4398 enrolled patients, overall mean age was 57 ± 11 years, 60% were males, 13% were smokers, 76% had diabetes, 71% had metabolic syndrome and 78% had very high ASCVD risk status. The proportion of subjects with body mass index <25 kg/m2, HbA1c <7% (in diabetics), low-density lipoprotein cholesterol (LDL-C) <2.6 mmol/L (100 mg/dL) and <1.8 mmol/L (70 mg/dL) for high and very high ASCVD risk cohorts, respectively and controlled blood pressure (<140/90 mmHg) was 14, 26, 31% and 60%, respectively. Only 1.4% of the participants had all of their CVD risk factors controlled with significant differences among the countries (P < .001). CVD risk goal attainment rates were significantly lower in those with very high ASCVD risk compared with those with high ASCVD risk status (P < .001). Females were also, generally, less likely to attain goals when compared with males (P < .001).

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Overall goal attainment rates of the different cardiovascular risk factors (smoking, BMI, HbA1c, LDL-C, and BP) stratified by atherosclerotic cardiovascular disease (ASCVD) risk status in the Arabian Gulf (N = 4398).Abbreviations: BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; BP, blood pressure.Criteria for ASCVD risk status was adapted from the National Lipid Association criteria22 for atherosclerotic cardiovascular disease. Highrisk group included patients with 3 major ASCVD risk factors, diabetes mellitus (type 1 or 2) with 0/1 major ASCVD risk factor and LDL-C190 mg/dL (5.02 mmol/L) (severe hypercholesterolemia). Very high ASCVD risk group included coronary heart disease, peripheral arterydisease, cerebrovascular disease and diabetes mellitus with 2 other major ASCVD risk factors.CVD risk factor goal attainments were no smoking, BMI <25 kg/m2, HbA1c <7% and LDL-C for the high and very high ASCVD risk patientswere LDL-C < 100 mg/dL (2.6 mmol/L) and LDL-C <70 mg/dL (1.8 mmol/L), respectively.BP goals were adapted from the new JNC-8 2014 Hypertension Guideline Management Algorithm.23 BP goals for those without diabetesmellitus (DM) and 60 years and those <60 years were <150/90 mmHg and <140/90 mmHg, respectively. For those with DM irrespective ofage, the BP goal was <140/90 mmHg.
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Figure 1: Overall goal attainment rates of the different cardiovascular risk factors (smoking, BMI, HbA1c, LDL-C, and BP) stratified by atherosclerotic cardiovascular disease (ASCVD) risk status in the Arabian Gulf (N = 4398).Abbreviations: BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; BP, blood pressure.Criteria for ASCVD risk status was adapted from the National Lipid Association criteria22 for atherosclerotic cardiovascular disease. Highrisk group included patients with 3 major ASCVD risk factors, diabetes mellitus (type 1 or 2) with 0/1 major ASCVD risk factor and LDL-C190 mg/dL (5.02 mmol/L) (severe hypercholesterolemia). Very high ASCVD risk group included coronary heart disease, peripheral arterydisease, cerebrovascular disease and diabetes mellitus with 2 other major ASCVD risk factors.CVD risk factor goal attainments were no smoking, BMI <25 kg/m2, HbA1c <7% and LDL-C for the high and very high ASCVD risk patientswere LDL-C < 100 mg/dL (2.6 mmol/L) and LDL-C <70 mg/dL (1.8 mmol/L), respectively.BP goals were adapted from the new JNC-8 2014 Hypertension Guideline Management Algorithm.23 BP goals for those without diabetesmellitus (DM) and 60 years and those <60 years were <150/90 mmHg and <140/90 mmHg, respectively. For those with DM irrespective ofage, the BP goal was <140/90 mmHg.

Mentions: Goal attainment rates of the different CVD risk factors (smoking, BMI, HbA1c, LDL-C and BP) stratified by high and very high ASCVD risk patients is outlined in 1. The number of patients that achieved 1, 2, 3 and 4 goals were (20%; n = 877), (37%; n = 1629), (29%; n = 1283) and (11%; n = 471), respectively. Only 1.4% (n = 61) of the subjects had all the 5 CVD risk factors at goal. Patients with very high ASCVD risk were more likely to make goal if they had only 1 risk factor (23 vs. 8.4%; P < .001). However, for those with more CVD risk factors, those with very high ASCVD risk were less likely to attain goal when compared with those with only high ASCVD risk (3 risk factors (27 vs. 38%; P < .001) and 4 risk factors (8.7 vs. 18%; P < .001)).


Control of Risk Factors for Cardiovascular Disease among Multinational Patient Population in the Arabian Gulf
Overall goal attainment rates of the different cardiovascular risk factors (smoking, BMI, HbA1c, LDL-C, and BP) stratified by atherosclerotic cardiovascular disease (ASCVD) risk status in the Arabian Gulf (N = 4398).Abbreviations: BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; BP, blood pressure.Criteria for ASCVD risk status was adapted from the National Lipid Association criteria22 for atherosclerotic cardiovascular disease. Highrisk group included patients with 3 major ASCVD risk factors, diabetes mellitus (type 1 or 2) with 0/1 major ASCVD risk factor and LDL-C190 mg/dL (5.02 mmol/L) (severe hypercholesterolemia). Very high ASCVD risk group included coronary heart disease, peripheral arterydisease, cerebrovascular disease and diabetes mellitus with 2 other major ASCVD risk factors.CVD risk factor goal attainments were no smoking, BMI <25 kg/m2, HbA1c <7% and LDL-C for the high and very high ASCVD risk patientswere LDL-C < 100 mg/dL (2.6 mmol/L) and LDL-C <70 mg/dL (1.8 mmol/L), respectively.BP goals were adapted from the new JNC-8 2014 Hypertension Guideline Management Algorithm.23 BP goals for those without diabetesmellitus (DM) and 60 years and those <60 years were <150/90 mmHg and <140/90 mmHg, respectively. For those with DM irrespective ofage, the BP goal was <140/90 mmHg.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4997936&req=5

Figure 1: Overall goal attainment rates of the different cardiovascular risk factors (smoking, BMI, HbA1c, LDL-C, and BP) stratified by atherosclerotic cardiovascular disease (ASCVD) risk status in the Arabian Gulf (N = 4398).Abbreviations: BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; BP, blood pressure.Criteria for ASCVD risk status was adapted from the National Lipid Association criteria22 for atherosclerotic cardiovascular disease. Highrisk group included patients with 3 major ASCVD risk factors, diabetes mellitus (type 1 or 2) with 0/1 major ASCVD risk factor and LDL-C190 mg/dL (5.02 mmol/L) (severe hypercholesterolemia). Very high ASCVD risk group included coronary heart disease, peripheral arterydisease, cerebrovascular disease and diabetes mellitus with 2 other major ASCVD risk factors.CVD risk factor goal attainments were no smoking, BMI <25 kg/m2, HbA1c <7% and LDL-C for the high and very high ASCVD risk patientswere LDL-C < 100 mg/dL (2.6 mmol/L) and LDL-C <70 mg/dL (1.8 mmol/L), respectively.BP goals were adapted from the new JNC-8 2014 Hypertension Guideline Management Algorithm.23 BP goals for those without diabetesmellitus (DM) and 60 years and those <60 years were <150/90 mmHg and <140/90 mmHg, respectively. For those with DM irrespective ofage, the BP goal was <140/90 mmHg.
Mentions: Goal attainment rates of the different CVD risk factors (smoking, BMI, HbA1c, LDL-C and BP) stratified by high and very high ASCVD risk patients is outlined in 1. The number of patients that achieved 1, 2, 3 and 4 goals were (20%; n = 877), (37%; n = 1629), (29%; n = 1283) and (11%; n = 471), respectively. Only 1.4% (n = 61) of the subjects had all the 5 CVD risk factors at goal. Patients with very high ASCVD risk were more likely to make goal if they had only 1 risk factor (23 vs. 8.4%; P < .001). However, for those with more CVD risk factors, those with very high ASCVD risk were less likely to attain goal when compared with those with only high ASCVD risk (3 risk factors (27 vs. 38%; P < .001) and 4 risk factors (8.7 vs. 18%; P < .001)).

View Article: PubMed Central - PubMed

ABSTRACT

We evaluated the control of cardiovascular disease (CVD) risk factors among patients with atherosclerotic cardiovascular disease (ASCVD) in the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolaemia (CEPHEUS) in the Arabian Gulf. Of the 4398 enrolled patients, overall mean age was 57 &plusmn; 11 years, 60% were males, 13% were smokers, 76% had diabetes, 71% had metabolic syndrome and 78% had very high ASCVD risk status. The proportion of subjects with body mass index &lt;25 kg/m2, HbA1c &lt;7% (in diabetics), low-density lipoprotein cholesterol (LDL-C) &lt;2.6 mmol/L (100 mg/dL) and &lt;1.8 mmol/L (70 mg/dL) for high and very high ASCVD risk cohorts, respectively and controlled blood pressure (&lt;140/90 mmHg) was 14, 26, 31% and 60%, respectively. Only 1.4% of the participants had all of their CVD risk factors controlled with significant differences among the countries (P &lt; .001). CVD risk goal attainment rates were significantly lower in those with very high ASCVD risk compared with those with high ASCVD risk status (P &lt; .001). Females were also, generally, less likely to attain goals when compared with males (P &lt; .001).

No MeSH data available.


Related in: MedlinePlus