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Effect of Multiple Dietary Supplement Containing Lutein, 
 Astaxanthin, Cyanidin-3-Glucoside, and DHA on Accommodative Ability

View Article: PubMed Central

ABSTRACT

Objective: The study aimed to verify that ingestion of multiple dietary supplement containing lutein, astaxanthin, cyanidin-3-glucoside and docosahexaenoic acid (DHA) would improve accommodative ability of aged and older subjects who were aware of eye strain on a daily basis.

Methods: A randomized double-blind placebo-controlled parallel group comparison study was conducted for 48 participants aged 45 to 64 years who complained of eye strain. The subjects took multiple dietary supplement containing 10 mg of lutein, 20 mg of bilberry extract and 26.5 mg of black soybean hull extract (a total of 2.3 mg of cyanidin-3-glucoside in both extracts), 4 mg of astaxanthin, and 50 mg of DHA (test supplement) or placebo for four consecutive weeks. Near-point accommodation (NPA) and subjective symptoms were evaluated both before and after four weeks’ intake.

Results: The variation of the NPA of both eyes from baseline to 4 weeks’ post-intake in the test supplement group was significantly higher than in the placebo group (1.321±0.394 diopter (D) in the test supplement group and 0.108±0.336 D in the placebo group, p=0.023). The multiple dietary supplement group showed improvement in the NPA. Regarding subjective symptoms, significant improvement of “stiff shoulders or neck” and “blurred vision” was also found in the test supplement group compared to the placebo group (p<0.05). There were no safety concerns in this study.

Conclusion: This study shows that multiple dietary supplement containing lutein, astaxanthin, cyanidin-3-glucoside, and DHA has effect to improve accommodative ability and subjective symptoms related to eye fatigue.

No MeSH data available.


Flow diagram of participants in this study. Multiple dietary supplement was contained lutein, astaxanthin, bilberry extract and black soybean extract (as source of cyanidin-3-glucoside), and docosahexaenoic acid (DHA).
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Figure 1: Flow diagram of participants in this study. Multiple dietary supplement was contained lutein, astaxanthin, bilberry extract and black soybean extract (as source of cyanidin-3-glucoside), and docosahexaenoic acid (DHA).

Mentions: The flow diagram of participants in this study is shown in Fig. (1). A total of 102 volunteers underwent screening (pre-intake) tests, and 50 of them were chosen to participate in the study. Then, each of 25 subjects was assigned to either of the test supplement or the placebo groups. All the subjects completed this study to final visits. After reviewing the subjects, two of them were eliminated from the analysis: One subject of the test supplement group fall under the exclusion criteria (iv) because of a remarkably short amount of sleep the day before the visit after 4 weeks’ intake, which was considered difficult to assess appropriately. One subject of the placebo group fall under the exclusion criteria (iii) because of being unable to keep the eyes open for 30 seconds without blinking at the visit after 4 weeks’ intake. As a result, the PPS consisted of 48 subjects (24 in the test supplement group, and 24 in the placebo group). The intake rate of the test supplement in the PPS was 99.6% in the test supplement group, and 100% in the placebo group. There was no subject whose intake rate was below 80%.


Effect of Multiple Dietary Supplement Containing Lutein, 
 Astaxanthin, Cyanidin-3-Glucoside, and DHA on Accommodative Ability
Flow diagram of participants in this study. Multiple dietary supplement was contained lutein, astaxanthin, bilberry extract and black soybean extract (as source of cyanidin-3-glucoside), and docosahexaenoic acid (DHA).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4997915&req=5

Figure 1: Flow diagram of participants in this study. Multiple dietary supplement was contained lutein, astaxanthin, bilberry extract and black soybean extract (as source of cyanidin-3-glucoside), and docosahexaenoic acid (DHA).
Mentions: The flow diagram of participants in this study is shown in Fig. (1). A total of 102 volunteers underwent screening (pre-intake) tests, and 50 of them were chosen to participate in the study. Then, each of 25 subjects was assigned to either of the test supplement or the placebo groups. All the subjects completed this study to final visits. After reviewing the subjects, two of them were eliminated from the analysis: One subject of the test supplement group fall under the exclusion criteria (iv) because of a remarkably short amount of sleep the day before the visit after 4 weeks’ intake, which was considered difficult to assess appropriately. One subject of the placebo group fall under the exclusion criteria (iii) because of being unable to keep the eyes open for 30 seconds without blinking at the visit after 4 weeks’ intake. As a result, the PPS consisted of 48 subjects (24 in the test supplement group, and 24 in the placebo group). The intake rate of the test supplement in the PPS was 99.6% in the test supplement group, and 100% in the placebo group. There was no subject whose intake rate was below 80%.

View Article: PubMed Central

ABSTRACT

Objective: The study aimed to verify that ingestion of multiple dietary supplement containing lutein, astaxanthin, cyanidin-3-glucoside and docosahexaenoic acid (DHA) would improve accommodative ability of aged and older subjects who were aware of eye strain on a daily basis.

Methods: A randomized double-blind placebo-controlled parallel group comparison study was conducted for 48 participants aged 45 to 64 years who complained of eye strain. The subjects took multiple dietary supplement containing 10 mg of lutein, 20 mg of bilberry extract and 26.5 mg of black soybean hull extract (a total of 2.3 mg of cyanidin-3-glucoside in both extracts), 4 mg of astaxanthin, and 50 mg of DHA (test supplement) or placebo for four consecutive weeks. Near-point accommodation (NPA) and subjective symptoms were evaluated both before and after four weeks’ intake.

Results: The variation of the NPA of both eyes from baseline to 4 weeks’ post-intake in the test supplement group was significantly higher than in the placebo group (1.321±0.394 diopter (D) in the test supplement group and 0.108±0.336 D in the placebo group, p=0.023). The multiple dietary supplement group showed improvement in the NPA. Regarding subjective symptoms, significant improvement of “stiff shoulders or neck” and “blurred vision” was also found in the test supplement group compared to the placebo group (p<0.05). There were no safety concerns in this study.

Conclusion: This study shows that multiple dietary supplement containing lutein, astaxanthin, cyanidin-3-glucoside, and DHA has effect to improve accommodative ability and subjective symptoms related to eye fatigue.

No MeSH data available.