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Burn wound healing properties of asiaticoside and madecassoside

View Article: PubMed Central - PubMed

ABSTRACT

The healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo-vascularization, granulation, re-epithelialization, inflammation and wound contraction. Various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. The aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (AE) and madecassoside (MA), which are found in the herb Centella asiatica. The cytotoxic nature of the AE and MA were inspected and were confirmed to be non-toxic up to 500 ppm. The compounds AE and MA increased monocyte chemoattractant protein-1 production, but caused no significant effect on vascular endothelial growth factor production. In addition, an in vivo animal burn model was employed to represent the features of burn wound healing. Hence, the present results warrant the further investigation of C. asiatica extracts for use in burn healing.

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Related in: MedlinePlus

Histopathological evaluation of burn wounds treated with (A) Vaseline, (B) asiaticoside or (C) madecassoside on day 14 following injury.
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f2-etm-0-0-3459: Histopathological evaluation of burn wounds treated with (A) Vaseline, (B) asiaticoside or (C) madecassoside on day 14 following injury.

Mentions: On day 14, the control group displayed distinct fibrinoid necrosis in the subepidermal area, as demonstrated by the presence of collagen and fibrin, as well as evidence of degenerative changes. Furthermore, due to only minor skin outgrowth, re-epithelialization was not achieved and exudates were shown to cover the wound surface. Fibrinoid necrosis in selected areas of the subepidermis were noted, particularly in the wounds of the AE and MA groups. Furthermore, edema was detected in interstitial zone near the dermal region of the AE and MA groups. Re-epithelialization was incomplete; however, the lesions in the AE and MA groups appeared to be more severe compared with the control group (Fig. 2).


Burn wound healing properties of asiaticoside and madecassoside
Histopathological evaluation of burn wounds treated with (A) Vaseline, (B) asiaticoside or (C) madecassoside on day 14 following injury.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4997909&req=5

f2-etm-0-0-3459: Histopathological evaluation of burn wounds treated with (A) Vaseline, (B) asiaticoside or (C) madecassoside on day 14 following injury.
Mentions: On day 14, the control group displayed distinct fibrinoid necrosis in the subepidermal area, as demonstrated by the presence of collagen and fibrin, as well as evidence of degenerative changes. Furthermore, due to only minor skin outgrowth, re-epithelialization was not achieved and exudates were shown to cover the wound surface. Fibrinoid necrosis in selected areas of the subepidermis were noted, particularly in the wounds of the AE and MA groups. Furthermore, edema was detected in interstitial zone near the dermal region of the AE and MA groups. Re-epithelialization was incomplete; however, the lesions in the AE and MA groups appeared to be more severe compared with the control group (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

The healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo-vascularization, granulation, re-epithelialization, inflammation and wound contraction. Various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. The aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (AE) and madecassoside (MA), which are found in the herb Centella asiatica. The cytotoxic nature of the AE and MA were inspected and were confirmed to be non-toxic up to 500 ppm. The compounds AE and MA increased monocyte chemoattractant protein-1 production, but caused no significant effect on vascular endothelial growth factor production. In addition, an in vivo animal burn model was employed to represent the features of burn wound healing. Hence, the present results warrant the further investigation of C. asiatica extracts for use in burn healing.

No MeSH data available.


Related in: MedlinePlus