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Burn wound healing properties of asiaticoside and madecassoside

View Article: PubMed Central - PubMed

ABSTRACT

The healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo-vascularization, granulation, re-epithelialization, inflammation and wound contraction. Various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. The aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (AE) and madecassoside (MA), which are found in the herb Centella asiatica. The cytotoxic nature of the AE and MA were inspected and were confirmed to be non-toxic up to 500 ppm. The compounds AE and MA increased monocyte chemoattractant protein-1 production, but caused no significant effect on vascular endothelial growth factor production. In addition, an in vivo animal burn model was employed to represent the features of burn wound healing. Hence, the present results warrant the further investigation of C. asiatica extracts for use in burn healing.

No MeSH data available.


Chemical structure of (A) asiaticoside and (B) madecassoside.
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f1-etm-0-0-3459: Chemical structure of (A) asiaticoside and (B) madecassoside.

Mentions: Compounds AE and MA (Fig. 1) were applied to treat burn wounds established in a rat model of burn wound healing. Following day 2, it was noted that wounds in the untreated, Vaseline-control group were swollen and bruised. Conversely, a modest level of swelling were observed in all AE- and MA-treated groups. The majority of injuries in the AE and MA groups began to heal and formed fibrous tissue. Notably, on day 8 the wounds in the untreated control, AE and MA groups were dark red in color, displayed wound size decrement at the injury site and remained unchanged in terms of physical magnitude. Wound contraction was also observed in all treatment groups compared with the control groups (data not shown).


Burn wound healing properties of asiaticoside and madecassoside
Chemical structure of (A) asiaticoside and (B) madecassoside.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4997909&req=5

f1-etm-0-0-3459: Chemical structure of (A) asiaticoside and (B) madecassoside.
Mentions: Compounds AE and MA (Fig. 1) were applied to treat burn wounds established in a rat model of burn wound healing. Following day 2, it was noted that wounds in the untreated, Vaseline-control group were swollen and bruised. Conversely, a modest level of swelling were observed in all AE- and MA-treated groups. The majority of injuries in the AE and MA groups began to heal and formed fibrous tissue. Notably, on day 8 the wounds in the untreated control, AE and MA groups were dark red in color, displayed wound size decrement at the injury site and remained unchanged in terms of physical magnitude. Wound contraction was also observed in all treatment groups compared with the control groups (data not shown).

View Article: PubMed Central - PubMed

ABSTRACT

The healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo-vascularization, granulation, re-epithelialization, inflammation and wound contraction. Various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. The aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (AE) and madecassoside (MA), which are found in the herb Centella asiatica. The cytotoxic nature of the AE and MA were inspected and were confirmed to be non-toxic up to 500 ppm. The compounds AE and MA increased monocyte chemoattractant protein-1 production, but caused no significant effect on vascular endothelial growth factor production. In addition, an in vivo animal burn model was employed to represent the features of burn wound healing. Hence, the present results warrant the further investigation of C. asiatica extracts for use in burn healing.

No MeSH data available.