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Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais

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ABSTRACT

Background: The term dangerous universal blood donor refers to potential agglutination of the erythrocytes of non-O recipients due to plasma of an O blood group donor, which contains high titers of anti-A and/or anti-B hemagglutinins. Thus, prior titration of anti-A and anti-B hemagglutinins is recommended to prevent transfusion reactions.

Objective: The aim of this study was to estimate the frequency of dangerous universal donors in the blood bank of Belo Horizonte (Fundação Central de Imuno-Hematologia – Fundação Hemominas – Minas Gerais) by determining the titers of anti-A and anti-B hemagglutinins in O blood group donors.

Method: A total of 400 O blood group donors were randomly selected, from March 2014 to January 2015. The titers of anti-A and anti-B hemagglutinins (IgM and IgG classes) were obtained using the tube titration technique. Dangerous donors were those whose titers of anti-A or anti-B IgM were ≥128 and/or the titers of anti-A or anti-B IgG were ≥256. Donors were characterized according to gender, age and ethnicity. The hemagglutinins were characterized by specificity (anti-A and anti-B) and antibody class (IgG and IgM).

Results: Almost one-third (30.5%) of the O blood group donors were universal dangerous. The frequency among women was higher than that of men (p-value = 0.019; odds ratio: 1.66; 95% confidence interval: 1.08–2.56) and among young donors (18–29 years old) it was higher than for donors between 49 and 59 years old (p-value = 0.015; odds ratio: 3.05; 95% confidence interval: 1.22–7.69). There was no significant association between dangerous universal donors and ethnicity, agglutinin specificity or antibody class.

Conclusion: Especially platelet concentrates obtained by apheresis (that contain a substantial volume of plasma), coming from dangerous universal donors should be transfused in isogroup recipients whenever possible in order to prevent the occurrence of transfusion reactions.

No MeSH data available.


Absolute frequencies of evaluated donors stratified by ethnicity and classified as dangerous or non-dangerous.
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fig0015: Absolute frequencies of evaluated donors stratified by ethnicity and classified as dangerous or non-dangerous.

Mentions: Regarding ethnicity, of the 400 donors included in the survey, 136 declared themselves as White (34%), 54 as Black (13.5%), 208 as Mulatto (52%) and two as Asiatic (0.5%). Of the 122 donors classified as dangerous, 43 (35.2%) declared themselves as White, 20 (16.4%) as Black and 59 (48.4%) as Mulatto. On applying the chi-square and Fisher's exact tests, there was no association between the ethnical background and being classified as a dangerous donor (Figure 3).


Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais
Absolute frequencies of evaluated donors stratified by ethnicity and classified as dangerous or non-dangerous.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4997901&req=5

fig0015: Absolute frequencies of evaluated donors stratified by ethnicity and classified as dangerous or non-dangerous.
Mentions: Regarding ethnicity, of the 400 donors included in the survey, 136 declared themselves as White (34%), 54 as Black (13.5%), 208 as Mulatto (52%) and two as Asiatic (0.5%). Of the 122 donors classified as dangerous, 43 (35.2%) declared themselves as White, 20 (16.4%) as Black and 59 (48.4%) as Mulatto. On applying the chi-square and Fisher's exact tests, there was no association between the ethnical background and being classified as a dangerous donor (Figure 3).

View Article: PubMed Central - PubMed

ABSTRACT

Background: The term dangerous universal blood donor refers to potential agglutination of the erythrocytes of non-O recipients due to plasma of an O blood group donor, which contains high titers of anti-A and/or anti-B hemagglutinins. Thus, prior titration of anti-A and anti-B hemagglutinins is recommended to prevent transfusion reactions.

Objective: The aim of this study was to estimate the frequency of dangerous universal donors in the blood bank of Belo Horizonte (Fundação Central de Imuno-Hematologia – Fundação Hemominas – Minas Gerais) by determining the titers of anti-A and anti-B hemagglutinins in O blood group donors.

Method: A total of 400 O blood group donors were randomly selected, from March 2014 to January 2015. The titers of anti-A and anti-B hemagglutinins (IgM and IgG classes) were obtained using the tube titration technique. Dangerous donors were those whose titers of anti-A or anti-B IgM were ≥128 and/or the titers of anti-A or anti-B IgG were ≥256. Donors were characterized according to gender, age and ethnicity. The hemagglutinins were characterized by specificity (anti-A and anti-B) and antibody class (IgG and IgM).

Results: Almost one-third (30.5%) of the O blood group donors were universal dangerous. The frequency among women was higher than that of men (p-value = 0.019; odds ratio: 1.66; 95% confidence interval: 1.08–2.56) and among young donors (18–29 years old) it was higher than for donors between 49 and 59 years old (p-value = 0.015; odds ratio: 3.05; 95% confidence interval: 1.22–7.69). There was no significant association between dangerous universal donors and ethnicity, agglutinin specificity or antibody class.

Conclusion: Especially platelet concentrates obtained by apheresis (that contain a substantial volume of plasma), coming from dangerous universal donors should be transfused in isogroup recipients whenever possible in order to prevent the occurrence of transfusion reactions.

No MeSH data available.