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Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

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ABSTRACT

This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.

No MeSH data available.


Formation of the 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system in aurovertin B (118) biosynthesis [116].
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C18: Formation of the 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system in aurovertin B (118) biosynthesis [116].

Mentions: Aurovertin B. The 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system is present in several plant and microbial natural products, like decurrenside A from the goldenrod plant, sorangicin A from myxobacteria as well as the marine toxin palytoxin from zoanthids [112–114]. It was proposed that a complex epoxide opening cascade is involved in its formation (Scheme 18) [115].


Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
Formation of the 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system in aurovertin B (118) biosynthesis [116].
© Copyright Policy - Beilstein
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4979870&req=5

C18: Formation of the 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system in aurovertin B (118) biosynthesis [116].
Mentions: Aurovertin B. The 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system is present in several plant and microbial natural products, like decurrenside A from the goldenrod plant, sorangicin A from myxobacteria as well as the marine toxin palytoxin from zoanthids [112–114]. It was proposed that a complex epoxide opening cascade is involved in its formation (Scheme 18) [115].

View Article: PubMed Central - HTML - PubMed

ABSTRACT

This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.

No MeSH data available.