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High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction.

Huang CH, Kuo CL, Huang CS, Tseng WM, Lian IeB, Chang CC, Liu CS - Medicine (Baltimore) (2016)

Bottom Line: Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury.In addition, higher plasma CoQ10 concentration was associated with lower grade inflammatory and oxidative stress status.Therefore, plasma CoQ10 concentration may serve as a novel prognostic biomarker of LV systolic function after revascularization therapy for acute myocardial infarction.

View Article: PubMed Central - PubMed

Affiliation: aDivision of Cardiology, Department of Internal Medicine, Changhua Christian Hospital bInstitute of Statistics and Information Science, National Changhua University of Education cVascular and Genomic Research Center dDivision of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua eSchool of Medicine, Chung Shan Medical University, Taichung fDepartment of Neurology, Changhua Christian Hospital, Changhua gGraduate Institute of Integrative Medicine, China Medical University, Taichung, Taiwan.

ABSTRACT
Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury. However, it is unclear whether follow-up plasma CoQ10 concentration is prognostic of left ventricular (LV) performance after primary balloon angioplasty in patients with acute ST segment elevation myocardial infarction (STEMI).We prospectively recruited 55 patients with STEMI who were treated with primary coronary balloon angioplasty. Plasma CoQ10 concentrations were measured before primary angioplasty (baseline) and 3 days, 7 days, and 1 month after STEMI using high-performance liquid chromatography. Echocardiography was performed at baseline and at 6-month follow-up. The control group comprised 54 healthy age- and sex-matched volunteers.Serial circulating CoQ10 concentrations significantly decreased with time in the STEMI group. The LV ejection fraction at 6-month follow-up positively correlated with the 1-month plasma CoQ10 tertile. Higher plasma CoQ10 concentrations at 1 month were associated with favorable LV remodeling and systolic function 6 months after STEMI. Multiple linear regression analysis showed that changes in CoQ10 concentrations at 1-month follow-up were predictive of LV systolic function 6 months after STEMI. Changes in CoQ10 concentrations correlated negatively with baseline oxidized low-density lipoprotein and fibrinogen concentrations and correlated positively with leukocyte mitochondrial copy number at baseline.Patients with STEMI who had higher plasma CoQ10 concentrations 1 month after primary angioplasty had better LV performance at 6-month follow-up. In addition, higher plasma CoQ10 concentration was associated with lower grade inflammatory and oxidative stress status. Therefore, plasma CoQ10 concentration may serve as a novel prognostic biomarker of LV systolic function after revascularization therapy for acute myocardial infarction.

No MeSH data available.


Related in: MedlinePlus

Plasma CoQ10 concentration was positively proportional to the plasma ApoA1 tertile. Patients with AMI were divided into 3 subgroups according to the baseline ApoA1 concentration tertile: Group 1, ApoA1 concentration of ≤114 mg/dL (n = 19); Group 2, CoQ10 concentration of 115 to 128 mg/dL (n = 20); and Group 3, CoQ10 concentration of ≥129 mg/dL (n = 16). Trend analysis showed that the baseline plasma CoQ10 concentration was positively proportional to the baseline plasma ApoA1 concentration (Jonckheere–Terpstra test, P = 0.017). AMI = acute myocardial infarction, ApoA1 = apolipoprotein A1, CoQ10 = coenzyme Q10.
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Figure 5: Plasma CoQ10 concentration was positively proportional to the plasma ApoA1 tertile. Patients with AMI were divided into 3 subgroups according to the baseline ApoA1 concentration tertile: Group 1, ApoA1 concentration of ≤114 mg/dL (n = 19); Group 2, CoQ10 concentration of 115 to 128 mg/dL (n = 20); and Group 3, CoQ10 concentration of ≥129 mg/dL (n = 16). Trend analysis showed that the baseline plasma CoQ10 concentration was positively proportional to the baseline plasma ApoA1 concentration (Jonckheere–Terpstra test, P = 0.017). AMI = acute myocardial infarction, ApoA1 = apolipoprotein A1, CoQ10 = coenzyme Q10.

Mentions: Patients with STEMI were divided into 3 subgroups according to the baseline plasma ApoA1 concentration tertile. Trend analysis showed that the plasma CoQ10 concentration was positively proportional to the plasma ApoA1 concentration (Jonckheere–Terpstra test, P = 0.017) (Fig. 5).


High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction.

Huang CH, Kuo CL, Huang CS, Tseng WM, Lian IeB, Chang CC, Liu CS - Medicine (Baltimore) (2016)

Plasma CoQ10 concentration was positively proportional to the plasma ApoA1 tertile. Patients with AMI were divided into 3 subgroups according to the baseline ApoA1 concentration tertile: Group 1, ApoA1 concentration of ≤114 mg/dL (n = 19); Group 2, CoQ10 concentration of 115 to 128 mg/dL (n = 20); and Group 3, CoQ10 concentration of ≥129 mg/dL (n = 16). Trend analysis showed that the baseline plasma CoQ10 concentration was positively proportional to the baseline plasma ApoA1 concentration (Jonckheere–Terpstra test, P = 0.017). AMI = acute myocardial infarction, ApoA1 = apolipoprotein A1, CoQ10 = coenzyme Q10.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979854&req=5

Figure 5: Plasma CoQ10 concentration was positively proportional to the plasma ApoA1 tertile. Patients with AMI were divided into 3 subgroups according to the baseline ApoA1 concentration tertile: Group 1, ApoA1 concentration of ≤114 mg/dL (n = 19); Group 2, CoQ10 concentration of 115 to 128 mg/dL (n = 20); and Group 3, CoQ10 concentration of ≥129 mg/dL (n = 16). Trend analysis showed that the baseline plasma CoQ10 concentration was positively proportional to the baseline plasma ApoA1 concentration (Jonckheere–Terpstra test, P = 0.017). AMI = acute myocardial infarction, ApoA1 = apolipoprotein A1, CoQ10 = coenzyme Q10.
Mentions: Patients with STEMI were divided into 3 subgroups according to the baseline plasma ApoA1 concentration tertile. Trend analysis showed that the plasma CoQ10 concentration was positively proportional to the plasma ApoA1 concentration (Jonckheere–Terpstra test, P = 0.017) (Fig. 5).

Bottom Line: Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury.In addition, higher plasma CoQ10 concentration was associated with lower grade inflammatory and oxidative stress status.Therefore, plasma CoQ10 concentration may serve as a novel prognostic biomarker of LV systolic function after revascularization therapy for acute myocardial infarction.

View Article: PubMed Central - PubMed

Affiliation: aDivision of Cardiology, Department of Internal Medicine, Changhua Christian Hospital bInstitute of Statistics and Information Science, National Changhua University of Education cVascular and Genomic Research Center dDivision of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua eSchool of Medicine, Chung Shan Medical University, Taichung fDepartment of Neurology, Changhua Christian Hospital, Changhua gGraduate Institute of Integrative Medicine, China Medical University, Taichung, Taiwan.

ABSTRACT
Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury. However, it is unclear whether follow-up plasma CoQ10 concentration is prognostic of left ventricular (LV) performance after primary balloon angioplasty in patients with acute ST segment elevation myocardial infarction (STEMI).We prospectively recruited 55 patients with STEMI who were treated with primary coronary balloon angioplasty. Plasma CoQ10 concentrations were measured before primary angioplasty (baseline) and 3 days, 7 days, and 1 month after STEMI using high-performance liquid chromatography. Echocardiography was performed at baseline and at 6-month follow-up. The control group comprised 54 healthy age- and sex-matched volunteers.Serial circulating CoQ10 concentrations significantly decreased with time in the STEMI group. The LV ejection fraction at 6-month follow-up positively correlated with the 1-month plasma CoQ10 tertile. Higher plasma CoQ10 concentrations at 1 month were associated with favorable LV remodeling and systolic function 6 months after STEMI. Multiple linear regression analysis showed that changes in CoQ10 concentrations at 1-month follow-up were predictive of LV systolic function 6 months after STEMI. Changes in CoQ10 concentrations correlated negatively with baseline oxidized low-density lipoprotein and fibrinogen concentrations and correlated positively with leukocyte mitochondrial copy number at baseline.Patients with STEMI who had higher plasma CoQ10 concentrations 1 month after primary angioplasty had better LV performance at 6-month follow-up. In addition, higher plasma CoQ10 concentration was associated with lower grade inflammatory and oxidative stress status. Therefore, plasma CoQ10 concentration may serve as a novel prognostic biomarker of LV systolic function after revascularization therapy for acute myocardial infarction.

No MeSH data available.


Related in: MedlinePlus