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rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Ma C, Gu L, Yang M, Zhang Z, Zeng S, Song R, Xu C, Sun Y - Medicine (Baltimore) (2016)

Bottom Line: However, a number of studies conducted in various regions showed controversial results.And we verified this association in populations from Europe, America, and Asia.Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking.

View Article: PubMed Central - PubMed

Affiliation: aDepartment of Urology bDepartment of Nursing cDepartment of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

ABSTRACT
Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

No MeSH data available.


Related in: MedlinePlus

Forest plot of rs1495741 AA vs. GG/GA in never smoker.
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Figure 5: Forest plot of rs1495741 AA vs. GG/GA in never smoker.

Mentions: Compared to rs1495741 GG and GA genotypes (NAT2 intermediate and rapid acetylation phenotypes), the association between rs1495741 AA genotype (NAT2 slow acetylator) and bladder cancer susceptibility was evident in ever smoker (OR = 1.14, 95% CI = 1.08–1.21). And this result was consistent with subgroup analysis in Europe (OR = 1.12, 95% CI = 1.03–1.21) and America (OR = 1.19, 95% CI = 1.08–1.29), as was presented in Fig. 4. However, in nonsmoker, rs1495741 AA was not significantly increased susceptibility to bladder cancer when compared to GG and GA genotypes combined (OR = 0.93, 95% CI = 0.83–1.03, test for heterogeneity P = 0.95, I2 = 0.0%), shown in Fig. 5. Only the data from Pakistan study was from Asian population, which has been published before.[11]


rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Ma C, Gu L, Yang M, Zhang Z, Zeng S, Song R, Xu C, Sun Y - Medicine (Baltimore) (2016)

Forest plot of rs1495741 AA vs. GG/GA in never smoker.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979814&req=5

Figure 5: Forest plot of rs1495741 AA vs. GG/GA in never smoker.
Mentions: Compared to rs1495741 GG and GA genotypes (NAT2 intermediate and rapid acetylation phenotypes), the association between rs1495741 AA genotype (NAT2 slow acetylator) and bladder cancer susceptibility was evident in ever smoker (OR = 1.14, 95% CI = 1.08–1.21). And this result was consistent with subgroup analysis in Europe (OR = 1.12, 95% CI = 1.03–1.21) and America (OR = 1.19, 95% CI = 1.08–1.29), as was presented in Fig. 4. However, in nonsmoker, rs1495741 AA was not significantly increased susceptibility to bladder cancer when compared to GG and GA genotypes combined (OR = 0.93, 95% CI = 0.83–1.03, test for heterogeneity P = 0.95, I2 = 0.0%), shown in Fig. 5. Only the data from Pakistan study was from Asian population, which has been published before.[11]

Bottom Line: However, a number of studies conducted in various regions showed controversial results.And we verified this association in populations from Europe, America, and Asia.Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking.

View Article: PubMed Central - PubMed

Affiliation: aDepartment of Urology bDepartment of Nursing cDepartment of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

ABSTRACT
Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

No MeSH data available.


Related in: MedlinePlus