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rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Ma C, Gu L, Yang M, Zhang Z, Zeng S, Song R, Xu C, Sun Y - Medicine (Baltimore) (2016)

Bottom Line: However, a number of studies conducted in various regions showed controversial results.And we verified this association in populations from Europe, America, and Asia.Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking.

View Article: PubMed Central - PubMed

Affiliation: aDepartment of Urology bDepartment of Nursing cDepartment of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

ABSTRACT
Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

No MeSH data available.


Related in: MedlinePlus

rs1495741 and the risk of bladder cancer in different study regions.
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Figure 2: rs1495741 and the risk of bladder cancer in different study regions.

Mentions: As regards to G allele, rs149574 significantly reduced susceptibility to bladder cancer (OR = 0.85, 95% CI = 0.82–0.88, test for heterogeneity P = 0.36, I2 = 7.0%). Subgroup analysis by study region verified this association with OR = 0.84, 95% CI = 0.79–0.88 in Europe, OR = 0.87, 95% CI = 0.82–0.92 in America and OR = 0.86, 95% CI = 0.77–0.96 in Asia respectively and heterogeneity between groups P = 0.67 (Fig. 2). As for different study design (Supplemental Figure 1), rs1495741 was significantly negative associated with bladder cancer risk in cohort study (OR = 0.91, 95% CI = 0.83–0.98), hospital-based case-control study (OR = 0.83, 95% CI = 0.78–0.88), population-based case-control study (OR = 0.87, 95% CI = 0.80–0.93), and case-control study without further description (OR = 0.83, 95% CI = 0.75–0.92). Sensitivity analysis showed that the association between rs1495741 and bladder cancer was solid when any single study was omitted (Supplemental Figure 2). Both Begg's (P = 0.49) and Egger's test (P = 0.84) identified no significant publication bias, as can be seen in funnel graph (Fig. 3).


rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Ma C, Gu L, Yang M, Zhang Z, Zeng S, Song R, Xu C, Sun Y - Medicine (Baltimore) (2016)

rs1495741 and the risk of bladder cancer in different study regions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979814&req=5

Figure 2: rs1495741 and the risk of bladder cancer in different study regions.
Mentions: As regards to G allele, rs149574 significantly reduced susceptibility to bladder cancer (OR = 0.85, 95% CI = 0.82–0.88, test for heterogeneity P = 0.36, I2 = 7.0%). Subgroup analysis by study region verified this association with OR = 0.84, 95% CI = 0.79–0.88 in Europe, OR = 0.87, 95% CI = 0.82–0.92 in America and OR = 0.86, 95% CI = 0.77–0.96 in Asia respectively and heterogeneity between groups P = 0.67 (Fig. 2). As for different study design (Supplemental Figure 1), rs1495741 was significantly negative associated with bladder cancer risk in cohort study (OR = 0.91, 95% CI = 0.83–0.98), hospital-based case-control study (OR = 0.83, 95% CI = 0.78–0.88), population-based case-control study (OR = 0.87, 95% CI = 0.80–0.93), and case-control study without further description (OR = 0.83, 95% CI = 0.75–0.92). Sensitivity analysis showed that the association between rs1495741 and bladder cancer was solid when any single study was omitted (Supplemental Figure 2). Both Begg's (P = 0.49) and Egger's test (P = 0.84) identified no significant publication bias, as can be seen in funnel graph (Fig. 3).

Bottom Line: However, a number of studies conducted in various regions showed controversial results.And we verified this association in populations from Europe, America, and Asia.Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking.

View Article: PubMed Central - PubMed

Affiliation: aDepartment of Urology bDepartment of Nursing cDepartment of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

ABSTRACT
Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

No MeSH data available.


Related in: MedlinePlus