Limits...
rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Ma C, Gu L, Yang M, Zhang Z, Zeng S, Song R, Xu C, Sun Y - Medicine (Baltimore) (2016)

Bottom Line: However, a number of studies conducted in various regions showed controversial results.And we verified this association in populations from Europe, America, and Asia.Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking.

View Article: PubMed Central - PubMed

Affiliation: aDepartment of Urology bDepartment of Nursing cDepartment of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

ABSTRACT
Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

No MeSH data available.


Related in: MedlinePlus

Flowchart for the study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4979814&req=5

Figure 1: Flowchart for the study selection process.

Mentions: A total of 302 records, 133 from Pubmed, 62 from Embase, 103 from Web of Science and 4 from Wanfang Database were found under our search strategy. The complete literature selection process was shown in Fig. 1. By reviewing title and abstract, we excluded 281 articles, including 93 duplicate ones and 188 articles irrelevant to our objective. After full text screening, we removed other 11 records:5 reviews,[5,17–20] 3 meeting abstracts,[21–23] 1 letter to editor,[24] 1 commentary,[25] 1 editorial.[26] After data extraction from the left 10 articles,[8–12,14,27–30] 29 individual studies with 14,815 cases and 58,282 controls were enrolled in the present study to estimate relation of rs1495741 and bladder cancer risk. Of the included study, 14 studies were conducted in Europe, 13 in America (12 in USA and 1 in Venezuela, Latin America), and 2 in Asia. As regards to study design, 22 were retrospective case-control studies (10 hospital-based, 4 population-based, and 8 without further description) and 7 were prospective cohort studies. Lutherstadt Wittenberg Bladder Cancer Study (LWBCS) in Rothman et al's article was named East Germany Study (East Germany) in Selinski et al's publication on the same population.[9,11] We only included the data from Selinski et al's article to avoid duplication. The general characteristics of each study included in this meta-analysis were summarized in Table 1. We calculated pooled OR of other inheritance models based on genotype distribution data from 8 studies, whose details were shown in Supplemental Table 1.


rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Ma C, Gu L, Yang M, Zhang Z, Zeng S, Song R, Xu C, Sun Y - Medicine (Baltimore) (2016)

Flowchart for the study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979814&req=5

Figure 1: Flowchart for the study selection process.
Mentions: A total of 302 records, 133 from Pubmed, 62 from Embase, 103 from Web of Science and 4 from Wanfang Database were found under our search strategy. The complete literature selection process was shown in Fig. 1. By reviewing title and abstract, we excluded 281 articles, including 93 duplicate ones and 188 articles irrelevant to our objective. After full text screening, we removed other 11 records:5 reviews,[5,17–20] 3 meeting abstracts,[21–23] 1 letter to editor,[24] 1 commentary,[25] 1 editorial.[26] After data extraction from the left 10 articles,[8–12,14,27–30] 29 individual studies with 14,815 cases and 58,282 controls were enrolled in the present study to estimate relation of rs1495741 and bladder cancer risk. Of the included study, 14 studies were conducted in Europe, 13 in America (12 in USA and 1 in Venezuela, Latin America), and 2 in Asia. As regards to study design, 22 were retrospective case-control studies (10 hospital-based, 4 population-based, and 8 without further description) and 7 were prospective cohort studies. Lutherstadt Wittenberg Bladder Cancer Study (LWBCS) in Rothman et al's article was named East Germany Study (East Germany) in Selinski et al's publication on the same population.[9,11] We only included the data from Selinski et al's article to avoid duplication. The general characteristics of each study included in this meta-analysis were summarized in Table 1. We calculated pooled OR of other inheritance models based on genotype distribution data from 8 studies, whose details were shown in Supplemental Table 1.

Bottom Line: However, a number of studies conducted in various regions showed controversial results.And we verified this association in populations from Europe, America, and Asia.Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking.

View Article: PubMed Central - PubMed

Affiliation: aDepartment of Urology bDepartment of Nursing cDepartment of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

ABSTRACT
Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

No MeSH data available.


Related in: MedlinePlus