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Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

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ABSTRACT

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

No MeSH data available.


One-pot three-component synthesis of phosphorylated 2,6-dioxohexahydropyrimidines.
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C64: One-pot three-component synthesis of phosphorylated 2,6-dioxohexahydropyrimidines.

Mentions: Yavari et al. described the synthesis of phosphorylated 2,6-dioxohexahydropyrimidines 311 via a three-component reaction [102]. This method involved the one-pot reaction of N,N'-dimethylurea (310) and dialkyl acetylenedicarboxylates 309 in the presence of trialkyl phosphites 308 at room temperature (Scheme 64). The desired products were obtained in high yields between 84 and 94%.


Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates
One-pot three-component synthesis of phosphorylated 2,6-dioxohexahydropyrimidines.
© Copyright Policy - Beilstein
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4979670&req=5

C64: One-pot three-component synthesis of phosphorylated 2,6-dioxohexahydropyrimidines.
Mentions: Yavari et al. described the synthesis of phosphorylated 2,6-dioxohexahydropyrimidines 311 via a three-component reaction [102]. This method involved the one-pot reaction of N,N'-dimethylurea (310) and dialkyl acetylenedicarboxylates 309 in the presence of trialkyl phosphites 308 at room temperature (Scheme 64). The desired products were obtained in high yields between 84 and 94%.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

No MeSH data available.