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Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

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ABSTRACT

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

No MeSH data available.


The classical Reissert reaction.
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C50: The classical Reissert reaction.

Mentions: The traditional Reissert reaction is a one-pot treatment of quinoline (242) with acid chlorides 243 and KCN to afford Reissert compound 244 which can be hydrolyzed to give quinoline-2-carboxylic acid (245) (Scheme 50) [87].


Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates
The classical Reissert reaction.
© Copyright Policy - Beilstein
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4979670&req=5

C50: The classical Reissert reaction.
Mentions: The traditional Reissert reaction is a one-pot treatment of quinoline (242) with acid chlorides 243 and KCN to afford Reissert compound 244 which can be hydrolyzed to give quinoline-2-carboxylic acid (245) (Scheme 50) [87].

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

No MeSH data available.