Limits...
Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic

View Article: PubMed Central - PubMed

ABSTRACT

As one of the most common complications of diabetes, diabetic neuropathy often causes foot ulcers and even limb amputations. Inspite of continuous development in antidiabetic drugs, there is still no efficient therapy to cure diabetic neuropathy. Diabetic neuropathy shows declined vascularity in peripheral nerves and lack of angiogenic and neurotrophic factors. Mesenchymal stem cells (MSCs) have been indicated as a novel emerging regenerative therapy for diabetic neuropathy because of their multipotency. We will briefly review the pathogenesis of diabetic neuropathy, characteristic of MSCs, effects of MSC therapies for diabetic neuropathy and its related mechanisms. In order to treat diabetic neuropathy, neurotrophic or angiogenic factors in the form of protein or gene therapy are delivered to diabetic neuropathy, but therapeutic efficiencies are very modest if not ineffective. MSC treatment reverses manifestations of diabetic neuropathy. MSCs have an important role to repair tissue and to lower blood glucose level. MSCs even paracrinely secrete neurotrophic factors, angiogenic factors, cytokines, and immunomodulatory substances to ameliorate diabetic neuropathy. There are still several challenges in the clinical translation of MSC therapy, such as safety, optimal dose of administration, optimal mode of cell delivery, issues of MSC heterogeneity, clinically meaningful engraftment, autologous or allogeneic approach, challenges with cell manufacture, and further mechanisms.

No MeSH data available.


Related in: MedlinePlus

Mechanisms of the effect of stem cell transplantation on diabetic neuropathy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4979500&req=5

fig2: Mechanisms of the effect of stem cell transplantation on diabetic neuropathy.

Mentions: MSC therapy may not be a standard treatment option for all stages of DN because different stages of DN are marked by different structural or functional changes. At present, MSC therapy may be applied to those patients who suffer from intractable symptoms, acute exacerbation, or combined diseases, such as diabetic foot ulcers or critical limb ischemia. MSC therapies targeting both vascular and neural elements are advantageous in treating DN.50 One recent meta-analysis shows that BMSC transplantation ameliorates allodynia but not hyperalgesia unless it is given during the first 4 days after injury.51 As shown in Figure 2, stem cells can improve DN through two main pathways.


Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic
Mechanisms of the effect of stem cell transplantation on diabetic neuropathy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979500&req=5

fig2: Mechanisms of the effect of stem cell transplantation on diabetic neuropathy.
Mentions: MSC therapy may not be a standard treatment option for all stages of DN because different stages of DN are marked by different structural or functional changes. At present, MSC therapy may be applied to those patients who suffer from intractable symptoms, acute exacerbation, or combined diseases, such as diabetic foot ulcers or critical limb ischemia. MSC therapies targeting both vascular and neural elements are advantageous in treating DN.50 One recent meta-analysis shows that BMSC transplantation ameliorates allodynia but not hyperalgesia unless it is given during the first 4 days after injury.51 As shown in Figure 2, stem cells can improve DN through two main pathways.

View Article: PubMed Central - PubMed

ABSTRACT

As one of the most common complications of diabetes, diabetic neuropathy often causes foot ulcers and even limb amputations. Inspite of continuous development in antidiabetic drugs, there is still no efficient therapy to cure diabetic neuropathy. Diabetic neuropathy shows declined vascularity in peripheral nerves and lack of angiogenic and neurotrophic factors. Mesenchymal stem cells (MSCs) have been indicated as a novel emerging regenerative therapy for diabetic neuropathy because of their multipotency. We will briefly review the pathogenesis of diabetic neuropathy, characteristic of MSCs, effects of MSC therapies for diabetic neuropathy and its related mechanisms. In order to treat diabetic neuropathy, neurotrophic or angiogenic factors in the form of protein or gene therapy are delivered to diabetic neuropathy, but therapeutic efficiencies are very modest if not ineffective. MSC treatment reverses manifestations of diabetic neuropathy. MSCs have an important role to repair tissue and to lower blood glucose level. MSCs even paracrinely secrete neurotrophic factors, angiogenic factors, cytokines, and immunomodulatory substances to ameliorate diabetic neuropathy. There are still several challenges in the clinical translation of MSC therapy, such as safety, optimal dose of administration, optimal mode of cell delivery, issues of MSC heterogeneity, clinically meaningful engraftment, autologous or allogeneic approach, challenges with cell manufacture, and further mechanisms.

No MeSH data available.


Related in: MedlinePlus