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Congenital Zika syndrome with arthrogryposis: retrospective case series study.

van der Linden V, Filho EL, Lins OG, van der Linden A, Aragão Mde F, Brainer-Lima AM, Cruz DD, Rocha MA, Sobral da Silva PF, Carvalho MD, do Amaral FJ, Gomes JA, Ribeiro de Medeiros IC, Ventura CV, Ramos RC - BMJ (2016)

Bottom Line: Moderate signs of remodeling of the motor units and a reduced recruitment pattern were found on needle electromyography (monopolar).All presented malformations of cortical development, calcifications predominantly in the cortex and subcortical white matter (especially in the junction between the cortex and white matter), reduction in brain volume, ventriculomegaly, and hypoplasia of the brainstem and cerebellum.MRI of the spine in four children showed apparent thinning of the cord and reduced ventral roots.

View Article: PubMed Central - PubMed

Affiliation: Association for Assistance of Disabled Children, AACD, Recife, Brazil Barão de Lucena Hospital, HBL, Recife, Brazil vanessavdlinden@hotmail.com.

No MeSH data available.


Related in: MedlinePlus

Fig 3 Spine and brain magnetic resonance imaging of baby with arthrogryposis. Sagittal T2 weighted fast imaging employing steady state acquisition (FIESTA) (A) showing apparently reduced spinal cord thickness (short arrows) and mega cisterna magna (long arrow). Axial reconstruction of T2 weighted FIESTA (B) showing reduction of medullary cone ventral roots (long arrows) compared with dorsal roots (short arrows). Sagittal T2 weighted image (C) showing hypogenesis of corpus callosum (long white arrow), enlarged cisterna magna (long black arrow), enlarged fourth ventricle (short black arrow), and pons hypoplasia (short white arrow). Axial T2 weighted imaging (D) showing pachygyria in frontal lobes (black arrows) and severe ventriculomegaly, mainly at posterior part of lateral ventricles. Axial susceptibility weighted image (E and F) showing some hypointense small dystrophic calcifications (white arrows) in junction between cortical and subcortical white matter (E) and in midbrain (F)
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f3: Fig 3 Spine and brain magnetic resonance imaging of baby with arthrogryposis. Sagittal T2 weighted fast imaging employing steady state acquisition (FIESTA) (A) showing apparently reduced spinal cord thickness (short arrows) and mega cisterna magna (long arrow). Axial reconstruction of T2 weighted FIESTA (B) showing reduction of medullary cone ventral roots (long arrows) compared with dorsal roots (short arrows). Sagittal T2 weighted image (C) showing hypogenesis of corpus callosum (long white arrow), enlarged cisterna magna (long black arrow), enlarged fourth ventricle (short black arrow), and pons hypoplasia (short white arrow). Axial T2 weighted imaging (D) showing pachygyria in frontal lobes (black arrows) and severe ventriculomegaly, mainly at posterior part of lateral ventricles. Axial susceptibility weighted image (E and F) showing some hypointense small dystrophic calcifications (white arrows) in junction between cortical and subcortical white matter (E) and in midbrain (F)

Mentions: In four of the children, spinal MRI showed apparent cord thinning and reduced ventral roots. Figure 3 shows typical images of the brain and spine.


Congenital Zika syndrome with arthrogryposis: retrospective case series study.

van der Linden V, Filho EL, Lins OG, van der Linden A, Aragão Mde F, Brainer-Lima AM, Cruz DD, Rocha MA, Sobral da Silva PF, Carvalho MD, do Amaral FJ, Gomes JA, Ribeiro de Medeiros IC, Ventura CV, Ramos RC - BMJ (2016)

Fig 3 Spine and brain magnetic resonance imaging of baby with arthrogryposis. Sagittal T2 weighted fast imaging employing steady state acquisition (FIESTA) (A) showing apparently reduced spinal cord thickness (short arrows) and mega cisterna magna (long arrow). Axial reconstruction of T2 weighted FIESTA (B) showing reduction of medullary cone ventral roots (long arrows) compared with dorsal roots (short arrows). Sagittal T2 weighted image (C) showing hypogenesis of corpus callosum (long white arrow), enlarged cisterna magna (long black arrow), enlarged fourth ventricle (short black arrow), and pons hypoplasia (short white arrow). Axial T2 weighted imaging (D) showing pachygyria in frontal lobes (black arrows) and severe ventriculomegaly, mainly at posterior part of lateral ventricles. Axial susceptibility weighted image (E and F) showing some hypointense small dystrophic calcifications (white arrows) in junction between cortical and subcortical white matter (E) and in midbrain (F)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979356&req=5

f3: Fig 3 Spine and brain magnetic resonance imaging of baby with arthrogryposis. Sagittal T2 weighted fast imaging employing steady state acquisition (FIESTA) (A) showing apparently reduced spinal cord thickness (short arrows) and mega cisterna magna (long arrow). Axial reconstruction of T2 weighted FIESTA (B) showing reduction of medullary cone ventral roots (long arrows) compared with dorsal roots (short arrows). Sagittal T2 weighted image (C) showing hypogenesis of corpus callosum (long white arrow), enlarged cisterna magna (long black arrow), enlarged fourth ventricle (short black arrow), and pons hypoplasia (short white arrow). Axial T2 weighted imaging (D) showing pachygyria in frontal lobes (black arrows) and severe ventriculomegaly, mainly at posterior part of lateral ventricles. Axial susceptibility weighted image (E and F) showing some hypointense small dystrophic calcifications (white arrows) in junction between cortical and subcortical white matter (E) and in midbrain (F)
Mentions: In four of the children, spinal MRI showed apparent cord thinning and reduced ventral roots. Figure 3 shows typical images of the brain and spine.

Bottom Line: Moderate signs of remodeling of the motor units and a reduced recruitment pattern were found on needle electromyography (monopolar).All presented malformations of cortical development, calcifications predominantly in the cortex and subcortical white matter (especially in the junction between the cortex and white matter), reduction in brain volume, ventriculomegaly, and hypoplasia of the brainstem and cerebellum.MRI of the spine in four children showed apparent thinning of the cord and reduced ventral roots.

View Article: PubMed Central - PubMed

Affiliation: Association for Assistance of Disabled Children, AACD, Recife, Brazil Barão de Lucena Hospital, HBL, Recife, Brazil vanessavdlinden@hotmail.com.

No MeSH data available.


Related in: MedlinePlus