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Congenital Zika syndrome with arthrogryposis: retrospective case series study.

van der Linden V, Filho EL, Lins OG, van der Linden A, Aragão Mde F, Brainer-Lima AM, Cruz DD, Rocha MA, Sobral da Silva PF, Carvalho MD, do Amaral FJ, Gomes JA, Ribeiro de Medeiros IC, Ventura CV, Ramos RC - BMJ (2016)

Bottom Line: Moderate signs of remodeling of the motor units and a reduced recruitment pattern were found on needle electromyography (monopolar).All presented malformations of cortical development, calcifications predominantly in the cortex and subcortical white matter (especially in the junction between the cortex and white matter), reduction in brain volume, ventriculomegaly, and hypoplasia of the brainstem and cerebellum.MRI of the spine in four children showed apparent thinning of the cord and reduced ventral roots.

View Article: PubMed Central - PubMed

Affiliation: Association for Assistance of Disabled Children, AACD, Recife, Brazil Barão de Lucena Hospital, HBL, Recife, Brazil vanessavdlinden@hotmail.com.

No MeSH data available.


Related in: MedlinePlus

Fig 1 (A) Contracture in flexion of knee; (B) hyperextension of knee (knee dislocation); (C) clubfeet; (D) deformities in 2nd, 3rd, and 4th fingers; (E) joint contractures in legs and arms, without involvement of trunk
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f1: Fig 1 (A) Contracture in flexion of knee; (B) hyperextension of knee (knee dislocation); (C) clubfeet; (D) deformities in 2nd, 3rd, and 4th fingers; (E) joint contractures in legs and arms, without involvement of trunk

Mentions: Arthrogryposis was present in both the arms and the legs of six children (86%) and in the legs of one child (14%). Several leg deformities were observed: congenital clubfoot in six children (86%), which was bilateral in three (43%); knee flexion contracture in five children (71%), which was bilateral in three (43%) and unilateral in two (29%); hyperextension associated with subluxation of the knee in three children (43%), which was bilateral in two (29%); and contractures of hip flexion, adduction, and external rotation associated with irreducible bilateral dislocation that is not reducible to manoeuvre of Ortolani in all seven children. In all seven children, spinal deformities were not identified in either the sagittal or the coronal plane on plain radiography. The chest was barrel-like in four children (57%). Deformities identified in the arms were camptodactyly in six children (86%), which was bilateral in five (71.4%), and deformations of flexion in the second to fifth chirodactylus in all seven children. Adduction of the thumb was present in five children (71%), abduction of the thumb in two (29%), a bilateral simian crease in one (14%); deformities in hyperextension of the elbow in four (57%); flexion contracture in two (29%), which was bilateral; and decreased range of motion of the shoulder with contracture in adduction and internal rotation in two (29%). Figure 1 shows the clinical pictures of children with arthrogryposis.


Congenital Zika syndrome with arthrogryposis: retrospective case series study.

van der Linden V, Filho EL, Lins OG, van der Linden A, Aragão Mde F, Brainer-Lima AM, Cruz DD, Rocha MA, Sobral da Silva PF, Carvalho MD, do Amaral FJ, Gomes JA, Ribeiro de Medeiros IC, Ventura CV, Ramos RC - BMJ (2016)

Fig 1 (A) Contracture in flexion of knee; (B) hyperextension of knee (knee dislocation); (C) clubfeet; (D) deformities in 2nd, 3rd, and 4th fingers; (E) joint contractures in legs and arms, without involvement of trunk
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4979356&req=5

f1: Fig 1 (A) Contracture in flexion of knee; (B) hyperextension of knee (knee dislocation); (C) clubfeet; (D) deformities in 2nd, 3rd, and 4th fingers; (E) joint contractures in legs and arms, without involvement of trunk
Mentions: Arthrogryposis was present in both the arms and the legs of six children (86%) and in the legs of one child (14%). Several leg deformities were observed: congenital clubfoot in six children (86%), which was bilateral in three (43%); knee flexion contracture in five children (71%), which was bilateral in three (43%) and unilateral in two (29%); hyperextension associated with subluxation of the knee in three children (43%), which was bilateral in two (29%); and contractures of hip flexion, adduction, and external rotation associated with irreducible bilateral dislocation that is not reducible to manoeuvre of Ortolani in all seven children. In all seven children, spinal deformities were not identified in either the sagittal or the coronal plane on plain radiography. The chest was barrel-like in four children (57%). Deformities identified in the arms were camptodactyly in six children (86%), which was bilateral in five (71.4%), and deformations of flexion in the second to fifth chirodactylus in all seven children. Adduction of the thumb was present in five children (71%), abduction of the thumb in two (29%), a bilateral simian crease in one (14%); deformities in hyperextension of the elbow in four (57%); flexion contracture in two (29%), which was bilateral; and decreased range of motion of the shoulder with contracture in adduction and internal rotation in two (29%). Figure 1 shows the clinical pictures of children with arthrogryposis.

Bottom Line: Moderate signs of remodeling of the motor units and a reduced recruitment pattern were found on needle electromyography (monopolar).All presented malformations of cortical development, calcifications predominantly in the cortex and subcortical white matter (especially in the junction between the cortex and white matter), reduction in brain volume, ventriculomegaly, and hypoplasia of the brainstem and cerebellum.MRI of the spine in four children showed apparent thinning of the cord and reduced ventral roots.

View Article: PubMed Central - PubMed

Affiliation: Association for Assistance of Disabled Children, AACD, Recife, Brazil Barão de Lucena Hospital, HBL, Recife, Brazil vanessavdlinden@hotmail.com.

No MeSH data available.


Related in: MedlinePlus