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Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis.

Ramesh S, Zalucky A, Hemmelgarn BR, Roberts DJ, Ahmed SB, Wilton SB, Jun M - BMC Nephrol (2016)

Bottom Line: Forty two studies (n = 80,382 patients) were included in the meta-analysis.The definitions and assessment of SCD varied across the included studies.There was evidence of significant heterogeneity (I(2) = 98; p < 0.001), which was not explained by subgroup analyses stratified by mean age, proportion of hypertensive or diabetic patients, follow-up time, study size, or type of cohort studied.

View Article: PubMed Central - PubMed

Affiliation: Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

ABSTRACT

Background: Although sudden cardiac death (SCD) is recognized as a distinct cause of death in patients with end stage renal disease (ESRD), its incidence has not been well summarized.

Methods: We performed a systematic review and meta-analysis of the literature based on a protocol developed a priori. We searched MEDLINE and EMBASE (inception to March 2015) for randomized controlled trials and cohort studies reporting the incidence of SCD in adult patients with ESRD on hemodialysis or peritoneal dialysis. We collected data on number of SCD as well as the definition of SCD for each individual study. A random-effects model was used to summarize the incidence of SCD. We conducted subgroup analyses to explore sources of heterogeneity.

Results: Forty two studies (n = 80,382 patients) were included in the meta-analysis. The incidence of SCD among adults with ESRD ranged from 0.4 to 10.04 deaths per 100 person-years. The definitions and assessment of SCD varied across the included studies. There was evidence of significant heterogeneity (I(2) = 98; p < 0.001), which was not explained by subgroup analyses stratified by mean age, proportion of hypertensive or diabetic patients, follow-up time, study size, or type of cohort studied.

Conclusion: Current estimates of the incidence of SCD among adults with ESRD vary widely. There is a need for further studies to more accurately estimate the incidence of SCD in patients with ESRD.

No MeSH data available.


Related in: MedlinePlus

Estimated incidence rate
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Fig3: Estimated incidence rate

Mentions: A total of 8,574 SCD events occurred in 80,382 participants over a follow-up that ranged between 1.5 and 10 years. The estimated incidence rate of SCD among adults with ESRD ranged from 0.4 to 10.04 deaths per 100 person-years (Fig. 3). We observed evidence of significant heterogeneity across the included studies (I2 = 98 %, p < 0.001) and therefore did not calculate a summative estimate of the incidence rates. Additionally, the incidence rates were not significantly different between the two most common definitions of SCD (p = 0.1). The incidence rate in studies that included time in their definition was 2.98 SCD per 100 person-years (95 % CI: 2.87–3.11) and was 2.66 SCD per 100 person-years 95 % CI: 2.57–2.76) for studies that included hyperkalemia in their definition.Fig. 3


Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis.

Ramesh S, Zalucky A, Hemmelgarn BR, Roberts DJ, Ahmed SB, Wilton SB, Jun M - BMC Nephrol (2016)

Estimated incidence rate
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940956&req=5

Fig3: Estimated incidence rate
Mentions: A total of 8,574 SCD events occurred in 80,382 participants over a follow-up that ranged between 1.5 and 10 years. The estimated incidence rate of SCD among adults with ESRD ranged from 0.4 to 10.04 deaths per 100 person-years (Fig. 3). We observed evidence of significant heterogeneity across the included studies (I2 = 98 %, p < 0.001) and therefore did not calculate a summative estimate of the incidence rates. Additionally, the incidence rates were not significantly different between the two most common definitions of SCD (p = 0.1). The incidence rate in studies that included time in their definition was 2.98 SCD per 100 person-years (95 % CI: 2.87–3.11) and was 2.66 SCD per 100 person-years 95 % CI: 2.57–2.76) for studies that included hyperkalemia in their definition.Fig. 3

Bottom Line: Forty two studies (n = 80,382 patients) were included in the meta-analysis.The definitions and assessment of SCD varied across the included studies.There was evidence of significant heterogeneity (I(2) = 98; p < 0.001), which was not explained by subgroup analyses stratified by mean age, proportion of hypertensive or diabetic patients, follow-up time, study size, or type of cohort studied.

View Article: PubMed Central - PubMed

Affiliation: Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

ABSTRACT

Background: Although sudden cardiac death (SCD) is recognized as a distinct cause of death in patients with end stage renal disease (ESRD), its incidence has not been well summarized.

Methods: We performed a systematic review and meta-analysis of the literature based on a protocol developed a priori. We searched MEDLINE and EMBASE (inception to March 2015) for randomized controlled trials and cohort studies reporting the incidence of SCD in adult patients with ESRD on hemodialysis or peritoneal dialysis. We collected data on number of SCD as well as the definition of SCD for each individual study. A random-effects model was used to summarize the incidence of SCD. We conducted subgroup analyses to explore sources of heterogeneity.

Results: Forty two studies (n = 80,382 patients) were included in the meta-analysis. The incidence of SCD among adults with ESRD ranged from 0.4 to 10.04 deaths per 100 person-years. The definitions and assessment of SCD varied across the included studies. There was evidence of significant heterogeneity (I(2) = 98; p < 0.001), which was not explained by subgroup analyses stratified by mean age, proportion of hypertensive or diabetic patients, follow-up time, study size, or type of cohort studied.

Conclusion: Current estimates of the incidence of SCD among adults with ESRD vary widely. There is a need for further studies to more accurately estimate the incidence of SCD in patients with ESRD.

No MeSH data available.


Related in: MedlinePlus