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Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.

Nagata Y, Watanabe T, Nagasaka K, Yamada M, Murai M, Takeuchi S, Murase M, Yazaki T, Murase T, Komatsu K, Kaizuka M, Sano M, Asano K, Ando C, Taniuchi N - BMC Complement Altern Med (2016)

Bottom Line: However, many GF users do not develop this disease and the association between GF and MP remains unclear.We summarized clinical findings of MP cases.This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oriental Traditional Medical Center, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. ynagata@suwachuo.jp.

ABSTRACT

Background: Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.

Methods: We used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.

Results: Ten MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.

Conclusions: This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

No MeSH data available.


Related in: MedlinePlus

GF administration period (years) in examined cases with or without MP (n = 52). There were several non-MP patients who exceeded MP cases for duration of administration period of GF. They did not develop MP in spite of their long-term GF administration. GF, gardenia fruit; MP, mesenteric phlebosclerosis
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Fig4: GF administration period (years) in examined cases with or without MP (n = 52). There were several non-MP patients who exceeded MP cases for duration of administration period of GF. They did not develop MP in spite of their long-term GF administration. GF, gardenia fruit; MP, mesenteric phlebosclerosis

Mentions: The average administration period was 11.1 years (range: 4.0 to 15.9 years) in MP cases (Table 3). We also investigated the relation of the administration period of GF for MP cases and non-MP patients. Regarding this point, GF was administered in several non-MP patients longer than the shortest administration period of MP cases (Fig. 4). However, there were significant differences in the duration of ambulatory visit and GF administration period between MP cases and non-MP patients (Table 3).Fig. 4


Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.

Nagata Y, Watanabe T, Nagasaka K, Yamada M, Murai M, Takeuchi S, Murase M, Yazaki T, Murase T, Komatsu K, Kaizuka M, Sano M, Asano K, Ando C, Taniuchi N - BMC Complement Altern Med (2016)

GF administration period (years) in examined cases with or without MP (n = 52). There were several non-MP patients who exceeded MP cases for duration of administration period of GF. They did not develop MP in spite of their long-term GF administration. GF, gardenia fruit; MP, mesenteric phlebosclerosis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940942&req=5

Fig4: GF administration period (years) in examined cases with or without MP (n = 52). There were several non-MP patients who exceeded MP cases for duration of administration period of GF. They did not develop MP in spite of their long-term GF administration. GF, gardenia fruit; MP, mesenteric phlebosclerosis
Mentions: The average administration period was 11.1 years (range: 4.0 to 15.9 years) in MP cases (Table 3). We also investigated the relation of the administration period of GF for MP cases and non-MP patients. Regarding this point, GF was administered in several non-MP patients longer than the shortest administration period of MP cases (Fig. 4). However, there were significant differences in the duration of ambulatory visit and GF administration period between MP cases and non-MP patients (Table 3).Fig. 4

Bottom Line: However, many GF users do not develop this disease and the association between GF and MP remains unclear.We summarized clinical findings of MP cases.This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oriental Traditional Medical Center, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. ynagata@suwachuo.jp.

ABSTRACT

Background: Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.

Methods: We used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.

Results: Ten MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.

Conclusions: This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

No MeSH data available.


Related in: MedlinePlus