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Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.

Nagata Y, Watanabe T, Nagasaka K, Yamada M, Murai M, Takeuchi S, Murase M, Yazaki T, Murase T, Komatsu K, Kaizuka M, Sano M, Asano K, Ando C, Taniuchi N - BMC Complement Altern Med (2016)

Bottom Line: However, many GF users do not develop this disease and the association between GF and MP remains unclear.We summarized clinical findings of MP cases.This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oriental Traditional Medical Center, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. ynagata@suwachuo.jp.

ABSTRACT

Background: Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.

Methods: We used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.

Results: Ten MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.

Conclusions: This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

No MeSH data available.


Related in: MedlinePlus

Clinical findings of colonoscopy and CT scan in MP cases (No. 1 in Table 2). Bronze coloration and redness in the ascending colon (a), bronze coloration in the hepatic flexure (b) and normal membrane in the descending colon (c) on colonoscopy. Linear calcification and wall thickening in the ascending colon (d) on CT scan. CT, computed tomography; MP, mesenteric phlebosclerosis
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Fig2: Clinical findings of colonoscopy and CT scan in MP cases (No. 1 in Table 2). Bronze coloration and redness in the ascending colon (a), bronze coloration in the hepatic flexure (b) and normal membrane in the descending colon (c) on colonoscopy. Linear calcification and wall thickening in the ascending colon (d) on CT scan. CT, computed tomography; MP, mesenteric phlebosclerosis

Mentions: The maximum dose of the MP cases was 15,792 g (No. 1 of Table 2). Colonoscopy showed typical bronze mucosa extending from the cecum to the transverse colon. Moreover, redness and erosion of the colonic membrane were observed in the cecum and the ascending colon (Fig. 2a, b). There was no color change in the descending colon (Fig. 2c). Severe wall thickening and typical linear calcification were observed on CT scan (Fig. 2d). The histological findings of moderate fibrotic lesions in pericapillary region of the lamina propria were observed (Fig. 3). Fibrillization was associated with a reduction of ductal cell density in part of the specimen.Fig. 2


Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.

Nagata Y, Watanabe T, Nagasaka K, Yamada M, Murai M, Takeuchi S, Murase M, Yazaki T, Murase T, Komatsu K, Kaizuka M, Sano M, Asano K, Ando C, Taniuchi N - BMC Complement Altern Med (2016)

Clinical findings of colonoscopy and CT scan in MP cases (No. 1 in Table 2). Bronze coloration and redness in the ascending colon (a), bronze coloration in the hepatic flexure (b) and normal membrane in the descending colon (c) on colonoscopy. Linear calcification and wall thickening in the ascending colon (d) on CT scan. CT, computed tomography; MP, mesenteric phlebosclerosis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940942&req=5

Fig2: Clinical findings of colonoscopy and CT scan in MP cases (No. 1 in Table 2). Bronze coloration and redness in the ascending colon (a), bronze coloration in the hepatic flexure (b) and normal membrane in the descending colon (c) on colonoscopy. Linear calcification and wall thickening in the ascending colon (d) on CT scan. CT, computed tomography; MP, mesenteric phlebosclerosis
Mentions: The maximum dose of the MP cases was 15,792 g (No. 1 of Table 2). Colonoscopy showed typical bronze mucosa extending from the cecum to the transverse colon. Moreover, redness and erosion of the colonic membrane were observed in the cecum and the ascending colon (Fig. 2a, b). There was no color change in the descending colon (Fig. 2c). Severe wall thickening and typical linear calcification were observed on CT scan (Fig. 2d). The histological findings of moderate fibrotic lesions in pericapillary region of the lamina propria were observed (Fig. 3). Fibrillization was associated with a reduction of ductal cell density in part of the specimen.Fig. 2

Bottom Line: However, many GF users do not develop this disease and the association between GF and MP remains unclear.We summarized clinical findings of MP cases.This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oriental Traditional Medical Center, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. ynagata@suwachuo.jp.

ABSTRACT

Background: Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.

Methods: We used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.

Results: Ten MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.

Conclusions: This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

No MeSH data available.


Related in: MedlinePlus