Limits...
Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.

Nagata Y, Watanabe T, Nagasaka K, Yamada M, Murai M, Takeuchi S, Murase M, Yazaki T, Murase T, Komatsu K, Kaizuka M, Sano M, Asano K, Ando C, Taniuchi N - BMC Complement Altern Med (2016)

Bottom Line: However, many GF users do not develop this disease and the association between GF and MP remains unclear.We summarized clinical findings of MP cases.This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oriental Traditional Medical Center, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. ynagata@suwachuo.jp.

ABSTRACT

Background: Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.

Methods: We used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.

Results: Ten MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.

Conclusions: This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

No MeSH data available.


Related in: MedlinePlus

Typical findings of CT scan in MP cases (No. 2 in Table 2). Typical calcification and wall thickening in the transverse colon (a) and the ascending colon (b). Linear calcification in the transverse colon in coronal section (c). The blue colored arrows indicate the typical calcification. The red colored arrows indicate the thickening in the colon. CT, computed tomography; MP, mesenteric phlebosclerosis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4940942&req=5

Fig1: Typical findings of CT scan in MP cases (No. 2 in Table 2). Typical calcification and wall thickening in the transverse colon (a) and the ascending colon (b). Linear calcification in the transverse colon in coronal section (c). The blue colored arrows indicate the typical calcification. The red colored arrows indicate the thickening in the colon. CT, computed tomography; MP, mesenteric phlebosclerosis

Mentions: Concerning the findings of CT scan, thickening of the affected colonic wall with calcification was observed in 5 of 9 MP cases who had a CT scan. Linear calcification of the mesenteric vein and its tributaries on CT scan was observed in 7 of 9 cases. Typical CT images were observed with a MP case (No. 2 of Table 2) (Fig. 1). Two cases continued to have slight calcification. Mild vasodilation of the ileocecal vein was observed in 1 of 9 cases.Fig. 1


Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.

Nagata Y, Watanabe T, Nagasaka K, Yamada M, Murai M, Takeuchi S, Murase M, Yazaki T, Murase T, Komatsu K, Kaizuka M, Sano M, Asano K, Ando C, Taniuchi N - BMC Complement Altern Med (2016)

Typical findings of CT scan in MP cases (No. 2 in Table 2). Typical calcification and wall thickening in the transverse colon (a) and the ascending colon (b). Linear calcification in the transverse colon in coronal section (c). The blue colored arrows indicate the typical calcification. The red colored arrows indicate the thickening in the colon. CT, computed tomography; MP, mesenteric phlebosclerosis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940942&req=5

Fig1: Typical findings of CT scan in MP cases (No. 2 in Table 2). Typical calcification and wall thickening in the transverse colon (a) and the ascending colon (b). Linear calcification in the transverse colon in coronal section (c). The blue colored arrows indicate the typical calcification. The red colored arrows indicate the thickening in the colon. CT, computed tomography; MP, mesenteric phlebosclerosis
Mentions: Concerning the findings of CT scan, thickening of the affected colonic wall with calcification was observed in 5 of 9 MP cases who had a CT scan. Linear calcification of the mesenteric vein and its tributaries on CT scan was observed in 7 of 9 cases. Typical CT images were observed with a MP case (No. 2 of Table 2) (Fig. 1). Two cases continued to have slight calcification. Mild vasodilation of the ileocecal vein was observed in 1 of 9 cases.Fig. 1

Bottom Line: However, many GF users do not develop this disease and the association between GF and MP remains unclear.We summarized clinical findings of MP cases.This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oriental Traditional Medical Center, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. ynagata@suwachuo.jp.

ABSTRACT

Background: Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.

Methods: We used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.

Results: Ten MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.

Conclusions: This study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.

No MeSH data available.


Related in: MedlinePlus