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The role of peptides in bone healing and regeneration: a systematic review.

Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, Giannoudis PV - BMC Med (2016)

Bottom Line: Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists.Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, UK.

ABSTRACT

Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration.

Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.

Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited.

Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge.

No MeSH data available.


Potential pathways and effect of peptides on the osteoblastic cell lines
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Fig2: Potential pathways and effect of peptides on the osteoblastic cell lines

Mentions: Parathyroid hormone (PTH) is an 84-amino acid, naturally occurring protein that plays a major regulatory role in mammalian mineral ion homeostasis. The peptide derived from its 34 amino acid domain has similar activity to the full length protein [224]. PTH1–34 is one of the earliest artificially synthesized amino acid fragments that was granted approval for the prevention and treatment of osteoporosis. Among its several functions, PTH1–34 stimulates osteoblast proliferation, differentiation and prevents their apoptosis (Fig. 2) [51].Fig. 2


The role of peptides in bone healing and regeneration: a systematic review.

Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, Giannoudis PV - BMC Med (2016)

Potential pathways and effect of peptides on the osteoblastic cell lines
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940902&req=5

Fig2: Potential pathways and effect of peptides on the osteoblastic cell lines
Mentions: Parathyroid hormone (PTH) is an 84-amino acid, naturally occurring protein that plays a major regulatory role in mammalian mineral ion homeostasis. The peptide derived from its 34 amino acid domain has similar activity to the full length protein [224]. PTH1–34 is one of the earliest artificially synthesized amino acid fragments that was granted approval for the prevention and treatment of osteoporosis. Among its several functions, PTH1–34 stimulates osteoblast proliferation, differentiation and prevents their apoptosis (Fig. 2) [51].Fig. 2

Bottom Line: Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists.Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, UK.

ABSTRACT

Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration.

Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.

Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited.

Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge.

No MeSH data available.